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ALLMedicine™ Generalized Tonic-clonic Seizures Center

Research & Reviews  450 results

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by...
https://doi.org/10.1111/epi.17236
Epilepsia Hirsch E, French J et. al.

May 4th, 2022 - In 2017, the International League Against Epilepsy (ILAE) Classification of Epilepsies described the "genetic generalized epilepsies" (GGEs), which contained the "idiopathic generalized epilepsies" (IGEs). The goal of this paper is to delineate th...

Quality of life in patients with symptomatic epilepsy due to neurocysticercosis.
https://doi.org/10.1016/j.yebeh.2022.108668
Epilepsy & Behavior : E&B; Zapata WR, Yang SY et. al.

Apr 29th, 2022 - Neurocysticercosis (NCC) is a common cause of late-onset epilepsy worldwide, but there is still minimal information regarding its impact on a patient's quality of life. This study evaluated quality of life in a series of patients with epilepsy sec...

Alterations in aortic vasorelaxation in rats with epilepsy induced by the electrical am...
https://doi.org/10.1016/j.eplepsyres.2022.106920
Epilepsy Research; Ghazale PP, Dos Santos Borges K et. al.

Apr 18th, 2022 - Cardiovascular alterations are frequently related to epilepsy in both clinical and experimental models, and have been hypothesized as a potential contributor to sudden unexpected death in epilepsy (SUDEP). Further, the frequency of generalized ton...

Molecular mechanisms of topiramate and its clinical value in epilepsy.
https://doi.org/10.1016/j.seizure.2022.03.024
Seizure Bai YF, Zeng C et. al.

Apr 15th, 2022 - Topiramate (TPM) is widely used as monotherapy or add-on therapy in adults and children (aged 2 to 16 years) with primary generalized tonic-clonic seizures or focal-onset seizures. TPM has also expanded its treatment spectrum to other seizure type...

Epilepsy and Seizures
https://emedicine.medscape.com/article/1184846-

Apr 13th, 2022 - Practice Essentials Epilepsy is defined as a brain disorder characterized by an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition. [1] Signs and sym...

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Guidelines  1 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

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Drugs  563 results see all →

Clinicaltrials.gov  11 results

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Sei...
https://clinicaltrials.gov/ct2/show/NCT03059381

May 7th, 2021 - The objective of this study is to identify the following in adolescent epilepsy participants with partial-onset seizures (with or without secondary generalized seizures) or primary generalized Tonic-clonic seizures who receive long-term treatment ...

A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subject...
https://clinicaltrials.gov/ct2/show/NCT01463306

Jan 20th, 2021 - Study A0081106 is a 12-month open-label study to evaluate the long term safety and tolerability of pregabalin as add-on therapy in pediatric subjects 1 month to 16 years of age with partial onset seizures and pediatric and adult subjects 5 to 65 y...

Embrace: Seizure Characterization
https://clinicaltrials.gov/ct2/show/NCT03206502

Aug 24th, 2020 - Patients use the Embrace sensor with a smartphone app, "Alert". The sensor attempts to capture convulsive seizure events such as generalized tonic-clonic seizures (GTCS's), and to initiate an alert when such an event is captured. Patients can also...

Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).
https://clinicaltrials.gov/ct2/show/NCT03790137

Aug 21st, 2019 - Sunflower Syndrome (also referred to as Self-induced Photosensitive Epilepsy) is a rare epileptic disorder characterized by a distinctive seizure that manifests itself in a highly stereotyped physical behavior. Seizure types associated with Sunflo...

A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)
https://clinicaltrials.gov/ct2/show/NCT01228747

Jan 15th, 2019 - The purpose of this study is to evaluate the efficacy, safety and tolerability of levetiracetam treatment used as adjunctive therapy in Japanese and Chinese epilepsy patients aged ≥16 years and with uncontrolled Generalized Tonic-Clonic seizures d...

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News  65 results

Phase 3 Data on Fenfluramine for Lennox-Gastaut Published
https://www.medscape.com/viewarticle/973485

May 5th, 2022 - A daily dose of fenfluramine (Fintepla, UCB), when added to an existing anti-epileptic treatment regimen, significantly reduced the frequency of drop seizures associated with Lennox-Gastaut syndrome (LGS) in the phase 3 study that led to US approv...

A Sexually Active 23-Year-Old With Seizures and Tongue Pain
https://www.medscape.com/viewarticle/865890

Oct 5th, 2021 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills us...

Seizure a First Sign of COVID in Kids?
https://www.medscape.com/viewarticle/958508

Sep 10th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Unlike in adults, seizures, including status epilepticus (SE), may be the first and main manifestation of COVID-19 in children, new research sugge...

Deeper Sleep, Slower Heart Rate Tied to Sudden Death in Epilepsy
https://www.medscape.com/viewarticle/951137

May 14th, 2021 - Deeper sleep and slower heart rate following seizures may work synergistically to increase the risk for sudden unexpected death in epilepsy (SUDEP), new research suggests. Investigators analyzed data on 100 seizures in 42 patients with epilepsy. T...

An Update on New Epilepsy Medications
https://www.medscape.com/viewarticle/949554

Apr 20th, 2021 - At the ongoing Academy of Neurology 2021 Annual Meeting, being held virtually on April 17-22, Joseph Sirven, MD, professor of neurology at the Mayo Clinic in Jacksonville, Florida, led an epilepsy course updating viewers on new epilepsy medication...

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Patient Education  1 results see all →