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About 3,218 results

ALLMedicine™ Generalized Tonic-clonic Seizures Center

Research & Reviews  561 results

Dravet syndrome: Advances in etiology, clinical presentation, and treatment.
https://doi.org/10.1016/j.eplepsyres.2022.107041
Epilepsy Research; He Z, Li Y et. al.

Nov 12th, 2022 - Dravet syndrome (DS) is a form of genetic refractory epilepsy. More than 80 % of DS patients carry pathogenic SCN1A mutations, and this percentage is actually higher due to false-negative results in gene testing. Potential genotype-phenotype corre...

Characteristics associated with drug resistant epilepsy in children up to 36 months old...
https://doi.org/10.1016/j.seizure.2022.11.001
Seizure Cavalcante TB, Ribeiro MRC et. al.

Nov 12th, 2022 - To verify characteristics associated with drug resistant epilepsy in children up to 36 months of age with Congenital Zika Syndrome (CZS). This is a prospective cohort study with children aged up to 36 months diagnosed with CZS. Obstetric, demograp...

The spectrum of epilepsy with eyelid myoclonia: delineation of disease subtypes from a ...
https://doi.org/10.1111/epi.17450
Epilepsia Cerulli Irelli E, Cocchi E et. al.

Oct 30th, 2022 - Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric outcome. However,...

Update on Sudden Unexpected Death in Epilepsy.
https://doi.org/10.1016/j.ncl.2022.06.001
Neurologic Clinics; Kløvgaard M, Sabers A et. al.

Oct 22nd, 2022 - Persons with epilepsy (PWE) have an up to 34-fold increased risk of dying suddenly and unexpectedly compared with the general population. Despite being potentially preventable by optimal care, sudden unexpected death in epilepsy (SUDEP) is one of ...

Brain Abscesses Caused by Nocardia farcinica in a 44-Year Old Woman with Multiple Myelo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597262
The American Journal of Case Reports; Sayer K, Abousedu YAI et. al.

Oct 22nd, 2022 - BACKGROUND Central nervous system infection by the Nocardia species is associated with high morbidity and mortality. Its occurrence in patients with multiple myeloma is rare and acquisition of the infection in such patients was associated with the...

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Guidelines  1 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005755
Neurology Kanner AM, Ashman E et. al.

Jun 15th, 2018 - To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria were used to systematically review literature...

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Drugs  595 results see all →

Clinicaltrials.gov  34 results

A Study to Evaluate the Effectiveness of Perampanel as Only Add-on Treatment in Participants With Primary or Secondarily Generalized Tonic-clonic Seizures
https://clinicaltrials.gov/ct2/show/NCT04202159

Oct 12th, 2022 - The primary purpose of this study is to investigate the effectiveness reflected by the retention rate of perampanel as the only add-on treatment in adult participants with primary generalized tonic-clonic (PGTC) or secondarily generalized tonic-cl...

Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures
https://clinicaltrials.gov/ct2/show/NCT02408549

Sep 23rd, 2022 - Assessment of long-term safety and efficacy of oral lacosamide (LCM) as an adjunctive therapy for uncontrolled primary generalized tonic-clonic seizures (PGTCS) in subjects >= 4 years of age with idiopathic generalized epilepsy (IGE). This study w...

Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).
https://clinicaltrials.gov/ct2/show/NCT03790137

Sep 21st, 2022 - Sunflower Syndrome (also referred to as Self-induced Photosensitive Epilepsy) is a rare epileptic disorder characterized by a distinctive seizure that manifests itself in a highly stereotyped physical behavior. Seizure types associated with Sunflo...

A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalizat...
https://clinicaltrials.gov/ct2/show/NCT04252846

Sep 7th, 2022 - The primary purpose of this study is to assess the retention rate of perampanel as a reliable proxy for overall effectiveness and tolerability in participants aged at least 12 years who are prescribed perampanel (for partial onset seizures [POS] w...

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Sei...
https://clinicaltrials.gov/ct2/show/NCT03059381

Aug 5th, 2022 - The objective of this study is to identify the following in adolescent epilepsy participants with partial-onset seizures (with or without secondary generalized seizures) or primary generalized Tonic-clonic seizures who receive long-term treatment ...

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News  94 results

Phase 3 Data on Fenfluramine for Lennox-Gastaut Published
https://www.medscape.com/viewarticle/973485

May 5th, 2022 - A daily dose of fenfluramine (Fintepla, UCB), when added to an existing anti-epileptic treatment regimen, significantly reduced the frequency of drop seizures associated with Lennox-Gastaut syndrome (LGS) in the phase 3 study that led to US approv...

A Sexually Active 23-Year-Old With Seizures and Tongue Pain
https://www.medscape.com/viewarticle/865890

Oct 5th, 2021 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills us...

Seizure a First Sign of COVID in Kids?
https://www.medscape.com/viewarticle/958508

Sep 10th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Unlike in adults, seizures, including status epilepticus (SE), may be the first and main manifestation of COVID-19 in children, new research sugge...

Deeper Sleep, Slower Heart Rate Tied to Sudden Death in Epilepsy
https://www.medscape.com/viewarticle/951137

May 14th, 2021 - Deeper sleep and slower heart rate following seizures may work synergistically to increase the risk for sudden unexpected death in epilepsy (SUDEP), new research suggests. Investigators analyzed data on 100 seizures in 42 patients with epilepsy. T...

An Update on New Epilepsy Medications
https://www.medscape.com/viewarticle/949554

Apr 20th, 2021 - At the ongoing Academy of Neurology 2021 Annual Meeting, being held virtually on April 17-22, Joseph Sirven, MD, professor of neurology at the Mayo Clinic in Jacksonville, Florida, led an epilepsy course updating viewers on new epilepsy medication...

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Patient Education  2 results see all →