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About 7,678 results

ALLMedicine™ Temporal Lobe Epilepsy Center

Research & Reviews  2,892 results

Reorganization of brain networks in patients with temporal lobe epilepsy and comorbid h...
https://doi.org/10.1016/j.yebeh.2023.109101
Epilepsy & Behavior : E&B; Yang S, Wu Y et. al.

Feb 4th, 2023 - The white matter structural network changes remain poorly understood in patients with temporal lobe epilepsy and comorbid headache (PWH). This study aimed at exploring topological changes in the structural network. Twenty-five PWH, 32 patients wit...

Quantitative evaluation of hippocampal gray-white matter boundary blurring in medial te...
https://doi.org/10.1016/j.yebeh.2023.109098
Epilepsy & Behavior : E&B; Tsuchiya T, Matsuo T et. al.

Feb 4th, 2023 - The magnetic resonance imaging (MRI) findings of hippocampal sclerosis (HS) include decreased volume, increased signal intensity, and hippocampal gray-white matter boundary blurring (HGWBB). Given that the layered structure is obscure in HS, there...

LINCs are vulnerable to epileptic insult and fail to provide seizure control via on-dem...
https://doi.org/10.1523/ENEURO.0195-22.2022
ENeuro Stieve BJ, Smith MM et. al.

Feb 2nd, 2023 - Temporal lobe epilepsy (TLE) is notoriously pharmacoresistant, and identifying novel therapeutic targets for controlling seizures is crucial. LINCs, a population of hippocampal neurons, were recently identified as a unique source of widespread inh...

Double-Edged Mossy Cells in Temporal Lobe Epilepsy: Evil in the Early Stage Through a B...
https://doi.org/10.1007/s12264-023-01030-z
Neuroscience Bulletin; Cheng H, Lou Q et. al.

Feb 1st, 2023 - Double-Edged Mossy Cells in Temporal Lobe Epilepsy: Evil in the Early Stage Through a BDNF-Dependent Strengthening Dentate Gyrus Circuit.|2023|Cheng H,Lou Q,Wang Y,Chen Z,|

Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail?
https://doi.org/10.1016/j.eplepsyres.2023.107086
Epilepsy Research; Dasgupta D, Finn R et. al.

Jan 30th, 2023 - Anteromesial temporal lobe resection is the most common surgical technique used to treat drug-resistant mesial temporal lobe epilepsy, particularly when secondary to hippocampal sclerosis. Structural and functional imaging data suggest the importa...

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Drugs  3 results see all →

Clinicaltrials.gov  61 results

Localizing Epileptic Networks Using MRI and iEEG
https://clinicaltrials.gov/ct2/show/NCT04649008

Jan 27th, 2023 - Despite recent advances in neuroimaging, approximately 2/3 of intractable epilepsy patients that undergo surgical evaluation continue to require intracranial EEG (IEEG), arguably the most invasive diagnostic test in medicine. Clinicians currently ...

FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05135091

Jan 25th, 2023 - Subjects will undergo a single stereotactic intracerebral administration of neural cells, called interneurons, that secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Subjects will then take medicines to partially suppress the...

Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05019404

Dec 30th, 2022 - Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures, followed by a latency period of several years after various injuries including febrile seizures, infection, trauma, tumors, and vascular malf...

Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
https://clinicaltrials.gov/ct2/show/NCT03958903

Dec 14th, 2022 - This study aims to specifically examine the in vivo electrophysiology and effects of direct stimulation of the human amygdala during conditioned and evoked fear. Investigators will also examine amygdala electrophysiology and the effects of stimula...

Surgery as a Treatment for Medically Intractable Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01273129

Nov 21st, 2022 - Objective This protocol is being performed to collect prospective data on patients who receive standard of care treatment for drug resistant epilepsy and to follow the natural history of patients receiving epilepsy surgery, to investigate neurophy...

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News  114 results

Improving Sleep Boosts Cognition in Refractory Temporal Lobe Epilepsy
https://www.medscape.com/viewarticle/985015

Dec 5th, 2022 - NASHVILLE, Tennessee ― Targeting relevant sleep problems for patients with refractory temporal lobe epilepsy (TLE) improves cognition, results of a new, double-blind, randomized controlled trial suggest. Study findings show significant improvement...

Functional outcomes of SLAH may be superior to those of open resection
https://www.mdedge.com/neurology/article/217175/epilepsy-seizures/functional-outcomes-slah-may-be-superior-those-open
Erik Greb

Feb 12th, 2020 - BALTIMORE – Among patients with medial temporal lobe epilepsy, functional outcomes of stereotactic laser amygdalohippocampotomy (SLAH) are superior to those of open resection, according to data presented at the annual meeting of the American Epile.

Should a normal-appearing hippocampus be resected in a patient with temporal lobe epilepsy?
https://www.mdedge.com/neurology/article/215839/epilepsy-seizures/should-normal-appearing-hippocampus-be-resected-patient
Erik Greb

Jan 21st, 2020 - BALTIMORE – Sparing, rather than resecting, a normal-appearing hippocampus in a patient with temporal lobe epilepsy is correlated with an increased risk of early seizure recurrence, according to an analysis presented at the annual meeting of the A.

Scalp EEG predicts temporal lobe resection success
https://www.mdedge.com/neurology/article/213858/epilepsy-seizures/scalp-eeg-predicts-temporal-lobe-resection-success
M. Alexander Otto

Dec 9th, 2019 - BALTIMORE – In a review of 43 temporal lobe epilepsy patients at Yale University in New Haven, Conn. , anteromedial temporal resection (AMTR) failed in every case in which initial ictal rhythm on scalp EEG spread beyond the medial temporal lobe to.

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/familymedicine/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year-may-be-better-among?channel=39313
Clinical Neurology News; Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

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Patient Education  1 results see all →