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About 6,723 results

ALLMedicine™ Temporal Lobe Epilepsy Center

Research & Reviews  2,602 results

Pulsed-Focused Ultrasound Provides Long-Term Suppression of Epileptiform Bursts in the ...
https://doi.org/10.1007/s13311-022-01250-7 10.1212/WNL.0000000000003509 10.1111/epi.13670 10.1001/archneur.1964.00460150003001 10.1016/S0920-1211(96)00043-5 10.1016/j.neubiorev.2013.10.011 10.1093/brain/awh449 10.1093/brain/awt223 10.1038/nrneurol.2012.181 10.1016/j.yebeh.2008.09.017 10.1001/jama.2014.17426 10.1080/14737175.2019.1554433 10.1016/S1474-4422(03)00664-1 10.1016/j.nurt.2009.02.002 10.1016/j.neuropharm.2012.05.016 10.1093/brain/awx379 10.1016/j.ultrasmedbio.2015.10.001 10.3171/2016.11.JNS16976 10.1016/j.conb.2018.04.011 10.1371/journal.pone.0003511 10.1038/s41598-018-28320-1 10.1186/1471-2202-12-23 10.1016/j.brs.2011.03.007 10.1016/j.yebeh.2015.04.008 10.1016/j.eplepsyres.2019.04.002 10.1016/j.brs.2019.09.011 10.1016/0014-2999(78)90302-3 10.1523/JNEUROSCI.1097-08.2008 10.1111/j.1600-0404.2008.01108.x 10.1093/neurosurgery/46.1.157 10.1016/S0025-6196(11)63776-2 10.1097/WNP.0b013e3182784729 10.1111/j.1528-1167.2005.00268.x 10.1126/science.127.3289.83 10.1097/WNR.0000000000000330 10.1016/0006-8993(91)90711-4 10.1038/nprot.2011.371 10.7150/thno.40520 10.1111/j.1528-1167.2010.02536.x 10.1016/j.ultrasmedbio.2018.12.015 10.1118/1.3668316 10.1088/0031-9155/55/18/001 10.1007/s00221-007-0991-3
Neurotherapeutics : the Journal of the American Society F... Chu PC, Yu HY et. al.

May 18th, 2022 - Focused ultrasound (FUS) has potential utility for modulating regional brain excitability and possibly aiding seizure control; however, the duration of any beneficial effect is unknown. This study explores the efficacy and time course of a short s...

Correlation between FDG-PET brain hypometabolism and PTSD symptoms in temporal lobe epi...
https://doi.org/10.1111/epi.17300
Epilepsia Soncin LD, Faure S et. al.

May 16th, 2022 - The relationship between post-traumatic stress disorder (PTSD) and focal epilepsy is poorly understood. It has been hypothesized that there is a complex and reciprocal potential reinforcement of the symptoms of each condition. In this study, we in...

SCN1A overexpression, associated with a genomic region marked by a risk variant for a c...
https://doi.org/10.1007/s00401-022-02429-0 10.1038/sdata.2017.107 10.1371/journal.pone.0054166 10.1056/NEJM198702263160901 10.1007/s00401-006-0187-0 10.1111/epi.12220 10.1016/j.gep.2011.01.003 10.1186/s13742-015-0047-8 10.1093/nar/gkz945 10.1086/320609 10.1016/j.ymthe.2019.08.018 10.1006/nimg.1998.0395 10.1016/j.mex.2018.03.002 10.1016/j.expneurol.2017.03.026 10.1016/j.neuropharm.2019.107735 10.1038/ng.3129 10.1109/42.906426 10.1016/S0896-6273(02)00569-X 10.1006/nimg.1998.0396 10.1038/NATURE13182 10.1093/nar/gky955 10.1002/ana.410340604 10.1126/science.aay6690 10.1016/j.celrep.2015.04.023 10.1038/nature21374 10.1038/s41467-018-07524-z 10.1111/epi.13639 10.1038/S41588-018-0062-7 10.1038/nn.3898 10.1093/brain/awt233 10.1101/GR.229102 10.1093/BIOINFORMATICS/BTX609 10.1016/S0920-1211(02)00121-3 10.1055/s-2002-35826 10.1038/ng.3988 10.1093/brain/awz292 10.1016/j.jneumeth.2015.03.009 10.1002/ana.24081 10.1006/meth.2001.1262 10.1038/ng.2653 10.1074/JBC.M111.310763 10.1016/j.neuropharm.2019.04.011 10.1186/1471-2199-9-102 10.1016/j.seizure.2013.04.023 10.1097/NEN.0b013e318238b9af 10.1111/j.1528-1167.2008.01969.x 10.1086/519795 10.1093/BIOINFORMATICS/BTP616 10.1016/j.nbd.2019.01.006 10.1111/j.1440-1789.2009.01018.x 10.1093/brain/awg262 10.1212/wnl.51.5.1256 10.1038/ng.2250 10.1046/j.1528-1157.2001.29000.x 10.1111/nan.12458 10.1016/S0140-6736(18)32596-0 10.1111/nan.12150 10.1038/nbt.3242 10.1111/epi.16789 10.1126/science.1260419 10.1093/brain/awx341 10.1111/j.0013-9580.2004.09004.x 10.1523/JNEUROSCI.2027-15.2016 10.1212/WNL.0000000000004384 10.1212/WNL.0b013e31820c309b 10.1007/s11682-008-9029-0
Acta Neuropathologica; Silvennoinen K, Gawel K et. al.

May 14th, 2022 - Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located in the promoter region of SCN1A. We sought to explore possible underlying mechanisms. SCN1A expres...

Patient-specific structural connectivity informs outcomes of responsive neurostimulatio...
https://doi.org/10.1111/epi.17298
Epilepsia Charlebois CM, Anderson DN et. al.

May 14th, 2022 - Responsive neurostimulation is an effective therapy for patients with refractory mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients become seizure-free, and the optimal stimulation location is currently undefined....

Quantitative and qualitative evaluation of the hippocampal cytoarchitecture in adult ca...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106214
PloS One; Zilli J, Schänzer A et. al.

May 14th, 2022 - Cats are known to be affected by hippocampal sclerosis, potentially causing antiseizure drug(s) resistance. In order to lay the foundation for a standardized, systematic classification and diagnosis of this pathology in cats, this prospective stud...

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Drugs  3 results see all →

Clinicaltrials.gov  19 results

Surgery as a Treatment for Medically Intractable Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01273129

May 13th, 2022 - Objective This protocol is being performed collect prospective data on patients who receive standard care therapy for drug resistant epilepsy and to follow the therapeutic course of patients from pre-operative evaluation, through surgery, and post...

Exercise for Brain Regeneration in Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05179083

May 5th, 2022 - Neurogenesis studies in healthy and dementia patients have only been performed on postmortem tissue, which prevents investigation of treatment outcomes. Patients with mesial temporal lobe epilepsy (MTLE) typically do not respond to medications and...

Thalamic Stimulation for Epilepsy Study
https://clinicaltrials.gov/ct2/show/NCT04102254

Apr 1st, 2022 - The purpose of this research is to examine the physiologic underpinnings of deep brain stimulation of the anterior nucleus of the thalamus (ANT), a method reducing seizures in adults diagnosed with medically refractory epilepsy. In this study, the...

Electrophysiological Biomarkers in MTLE Patients.
https://clinicaltrials.gov/ct2/show/NCT04710004

Mar 17th, 2022 - This is a nonrandomized interventional trial that will apply brain stimulation via clinically implanted intracranial electrodes to subjects with medial temporal lobe epilepsy with the purpose of identifying biomarkers related to the pre-ictal stat...

Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03946618

Feb 11th, 2022 - This study will include patients with dominant temporal lobe epilepsy and bilateral temporal lobe epilepsy. The plan is to have 10 patients take part in this study at Mayo Clinic Rochester.

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News  65 results

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/familymedicine/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year-may-be-better-among?channel=39313
Clinical Neurology News; Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/neurology/epilepsyresourcecenter/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year
Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

Antiepileptic drug outcomes have remained flat for 3 decades
https://www.mdedge.com/jcomjournal/article/205888/epilepsy-seizures/antiepileptic-drug-outcomes-have-remained-flat-3/page/0/1?channel=39313

Aug 5th, 2019 - Roughly similar outcomes have been reported from Norway in a study of 600 children with epilepsy, median age 7 years, with a median follow-up of 5. 8 years that is considerably shorter than that in the Glasgow pediatric study.

Seizure Freedom in TLE Tied to Piriform Cortex Resection
https://www.medscape.com/viewarticle/910752

Mar 21st, 2019 - Removal of at least half of the piriform cortex is required to achieve freedom from seizures in the neurosurgical treatment of temporal lobe epilepsy (TLE), new research suggests. A proof-of-concept study conducted by investigators at University C...

Seizure Freedom in TLE Tied to Piriform Cortex Resection
https://www.staging.medscape.com/viewarticle/910752

Mar 21st, 2019 - Removal of at least half of the piriform cortex is required to achieve freedom from seizures in the neurosurgical treatment of temporal lobe epilepsy (TLE), new research suggests. A proof-of-concept study conducted by investigators at University C...

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