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About 7,438 results

ALLMedicine™ Temporal Lobe Epilepsy Center

Research & Reviews  2,806 results

Diagnostic and prognostic value of EEG patterns recorded on foramen ovale and epidural ...
https://doi.org/10.1016/j.clinph.2022.08.027
Clinical Neurophysiology : Official Journal of the Intern... Miron G, Müller PM et. al.

Oct 3rd, 2022 - To describe and assess the significance of EEG characteristics recorded during presurgical video-EEG monitoring (VEM) utilizing foramen ovale (FO) and epidural peg electrodes. Seizure onset (SOP) and termination pattern morphology and regions, ips...

Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in m...
https://doi.org/10.1016/j.nbd.2022.105879
Neurobiology of Disease; Arshad MN, Oppenheimer S et. al.

Oct 3rd, 2022 - GABAergic interneurons play a role in regulating adult neurogenesis within the dentate gyrus (DG) of the hippocampus. Neurogenesis occurs within a stem cell niche in the subgranular zone (SGZ) of the DG. In this niche, populations of neural progen...

Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy...
https://doi.org/10.1007/s13311-022-01299-4
Neurotherapeutics : the Journal of the American Society F... Guarino A, Bettegazzi B et. al.

Oct 1st, 2022 - Temporal lobe epilepsy often manifests months or even years after an initial epileptogenic insult (e.g., stroke, trauma, status epilepticus) and, therefore, may be preventable. However, no such preventive treatment is currently available. Aim of t...

Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted ...
https://doi.org/10.1002/hbm.26083
Human Brain Mapping; Lucas A, Nanga RPR et. al.

Sep 30th, 2022 - Temporal lobe epilepsy (TLE) is one of the most common subtypes of focal epilepsy, with mesial temporal sclerosis (MTS) being a common radiological and histopathological finding. Accurate identification of MTS during presurgical evaluation confers...

CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRS...
https://doi.org/10.1111/nan.12850
Neuropathology and Applied Neurobiology; Zhao W, Li M et. al.

Sep 29th, 2022 - Several reports suggest that epigenetic therapy may be a potential method for treating epilepsy, and circular RNAs (circRNAs) play important roles in mediating the epigenetic mechanisms associated with epilepsy; however, currently there are no eff...

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Drugs  3 results see all →

Clinicaltrials.gov  60 results

FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
https://clinicaltrials.gov/ct2/show/NCT05135091

Sep 27th, 2022 - Subjects will undergo a single stereotactic intracerebral administration of neural cells, called interneurons, that secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Subjects will then take medicines to partially suppress the...

Epilepsy Surgery and Cognitive Outcome
https://clinicaltrials.gov/ct2/show/NCT04264780

Sep 23rd, 2022 - All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more, will be invited to participate. Two groups will be compared: patients who are younger than 50 years of age vs patients who are older than 50 years of a...

Surgery as a Treatment for Medically Intractable Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01273129

Sep 21st, 2022 - Objective This protocol is being performed collect prospective data on patients who receive standard care therapy for drug resistant epilepsy and to follow the therapeutic course of patients from pre-operative evaluation, through surgery, and post...

Localizing Epileptic Networks Using MRI and iEEG
https://clinicaltrials.gov/ct2/show/NCT04649008

Aug 30th, 2022 - Despite recent advances in neuroimaging, approximately 2/3 of intractable epilepsy patients that undergo surgical evaluation continue to require intracranial EEG (IEEG), arguably the most invasive diagnostic test in medicine. Clinicians currently ...

Thalamic Stimulation for Epilepsy Study
https://clinicaltrials.gov/ct2/show/NCT04102254

Aug 25th, 2022 - The purpose of this research is to examine the physiologic underpinnings of deep brain stimulation of the anterior nucleus of the thalamus (ANT), a method reducing seizures in adults diagnosed with medically refractory epilepsy. In this study, the...

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News  106 results

Functional outcomes of SLAH may be superior to those of open resection
https://www.mdedge.com/neurology/article/217175/epilepsy-seizures/functional-outcomes-slah-may-be-superior-those-open
Erik Greb

Feb 12th, 2020 - BALTIMORE – Among patients with medial temporal lobe epilepsy, functional outcomes of stereotactic laser amygdalohippocampotomy (SLAH) are superior to those of open resection, according to data presented at the annual meeting of the American Epile.

Should a normal-appearing hippocampus be resected in a patient with temporal lobe epilepsy?
https://www.mdedge.com/neurology/article/215839/epilepsy-seizures/should-normal-appearing-hippocampus-be-resected-patient
Erik Greb

Jan 21st, 2020 - BALTIMORE – Sparing, rather than resecting, a normal-appearing hippocampus in a patient with temporal lobe epilepsy is correlated with an increased risk of early seizure recurrence, according to an analysis presented at the annual meeting of the A.

Scalp EEG predicts temporal lobe resection success
https://www.mdedge.com/neurology/article/213858/epilepsy-seizures/scalp-eeg-predicts-temporal-lobe-resection-success
M. Alexander Otto

Dec 9th, 2019 - BALTIMORE – In a review of 43 temporal lobe epilepsy patients at Yale University in New Haven, Conn. , anteromedial temporal resection (AMTR) failed in every case in which initial ictal rhythm on scalp EEG spread beyond the medial temporal lobe to.

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/familymedicine/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year-may-be-better-among?channel=39313
Clinical Neurology News; Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

Outcomes of epilepsy surgery at 1 year may be better among older patients
https://www.mdedge.com/neurology/epilepsyresourcecenter/article/213808/epilepsy-seizures/outcomes-epilepsy-surgery-1-year
Erik Greb

Dec 8th, 2019 - BALTIMORE – Older patients may have better outcomes at 1 year after resective surgery for epilepsy than the general population does, according to research presented at the annual meeting of the American Epilepsy Society. A tendency toward greater.

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