ALLMedicine™ Dupuytren Contracture Center - Clinicaltrials.gov
A treatment for adults with Dupuytren's contracture with a palpable cord. See safety info including tendon rupture warning.
Metabolic Brain Disease; Finsterer J, Michalek-Sauberer A et. al.
Aug 28th, 2009 - Occasionally, patients with mitochondrial disorder (MID) develop malignant hyperthermia (MH)-like reactions or show an abnormal halothane-caffeine in-vitro contracture test. In a 66 year old Caucasian male with facial dysmorphism, epilepsy, chronic muscle cramps, repeatedly elevated creatine-kinase, Dupuytren contracture, and hypertrophic cardiomyopathy, a MID was found upon the clinical presen...
The Journal of Hand Surgery; Pess GM, Pess RM et. al.
Apr 2nd, 2012 - To critically review the efficacy, recurrence rate, and complications of needle aponeurotomy (NA) for the treatment of Dupuytren contracture. This was a retrospective study of the results of NA for the treatment of Dupuytren contracture. We included in the study all patients who had NA performed for metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint contracture of 20° or greater b...
The Journal of Hand Surgery; Peimer CA, Blazar P et. al.
Jun 22nd, 2015 - Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study was a 5-year noninterventional follow-up study to determine long-term efficacy and safety of collagenase clostridium histolyticum (CCH) treatment for Dupuytren contracture. Patients from previous CCH clinical studies were eligible. Enrolled patients were evaluated annually for contracture and safety at 2, 3, 4, a...
The Journal of Hand Surgery; McMillan C, Binhammer P
May 28th, 2012 - To compare flexion deformity at 6 months in patients with Dupuytren contracture who had percutaneous needle aponeurotomy (PNA) combined with a series of triamcinolone acetonide (TA) injections to that of patients who had PNA alone. Forty-seven patients with Dupuytren disease who were candidates for PNA (at least 1 contracture of at least 20°) participated in the study. Patients were randomized ...
Hand (New York, N.Y.); Kaplan FT, Badalamente MA et. al.
Sep 3rd, 2015 - Collagenase clostridium histolyticum (CCH) injection for Dupuytren contracture was approved in the USA in 2010. Current FDA guidelines stipulate that finger manipulation occurs the day following injection. To investigate the safety and efficacy of delaying manipulation to 2 or 4 days following CCH injection, we conducted a prospective, randomized trial at two sites. Patients with Dupuytren cont...
The Journal of the American Osteopathic Association; Sampson S, Meng M et. al.
Mar 1st, 2011 - Dupuytren contracture is a debilitating disease that characteristically presents as a firm nodularity on the palmar surface of the hand with coalescing cords of soft tissue on the webs and digits. With few nonsurgical modalities providing clinical benefits, open surgical procedures are the standard of care for patients with this condition. However, recent studies have associated surgical interv...
Annals of Plastic Surgery; Raven RB, Kushner H et. al.
Mar 20th, 2013 - Collagenase Clostridium histolyticum (CCH) injection is a nonoperative treatment of hand contractures from Dupuytren disease. This study assessed the efficacy and safety of CCH in several subgroups of patients with increased surgical risk.Data were pooled from 3 randomized, placebo-controlled, double-blind trials. This analysis included 271 patients with metacarpophalangeal (n = 167) or proxima...
David R. Steinberg
Oct 31st, 2016 - Dupuytren contracture is progressive contracture of the palmar fascial bands, causing flexion deformities of the fingers. Treatment is with corticosteroid injection, surgery, or injections of clostridial collagenase.
The Journal of Hand Surgery; Samargandi OA, Alyouha S et. al.
Sep 4th, 2017 - To determine the role of night orthosis use after surgical correction of Dupuytren contracture. We searched MEDLINE, EMBASE, CINAHL, AMED, OTSeeker, and CENTRAL for articles published from inception of the databases to August 2015. Assessment was undertaken by 2 independent reviewers (O.A.S. and S.A.). Methodological quality of randomized controlled trials was assessed using the Cochrane risk o...
Thomas R. Hunt III, MD
The Journal of Hand Surgery; Lesiak AC, Jarrett NJ et. al.
Mar 5th, 2017 - Despite recent advancements in the nonsurgical treatment for Dupuytren contracture, a number of patients remain poor nonsurgical candidates or elect for surgical management. The traditional McCash technique releases contractures while leaving open palmar wounds. Although successful in alleviating contractures, these wounds are traditionally large, transverse incisions across the palm. A modific...
The Journal of Hand Surgery; Wehrli M, Hensler S et. al.
Jul 29th, 2016 - The brief Michigan Hand Outcomes Questionnaire (briefMHQ) was developed as a shorter version of the Michigan Hand Outcomes Questionnaire (MHQ), but its measurement properties have not been investigated in patients with Dupuytren contracture. The objective of the study was to investigate the reliability, validity, responsiveness, and interpretability of the briefMHQ. Fifty-seven patients diagnos...
The Journal of Hand Surgery; Strömberg J, Ibsen-Sörensen A et. al.
Jul 30th, 2016 - This study compared the efficacy of collagenase treatment and needle fasciotomy for contracture of the metacarpophalangeal (MCP) joint in Dupuytren disease. This is a prospective, single-blinded, randomized study with follow-up 1 week and 1 year after treatment. One hundred and forty patients with an MCP contracture of 20° or more in a single finger were enrolled, of whom 69 patients were rando...
The Journal of Bone and Joint Surgery. American Volume; Strömberg J, Ibsen Sörensen A et. al.
Jul 5th, 2018 - Local disruption of the cord that causes contracture of the finger in Dupuytren disease can be achieved either through mechanical division by percutaneous needle fasciotomy (PNF) or through enzymatic digestion by injectable collagenase Clostridium histolyticum (CCH). This study was designed to compare clinical and patient-reported outcomes between patients who had been treated with each method....
Hand (New York, N.Y.); Buller M, Schulz S et. al.
Jul 11th, 2017 - To determine the incidence of complex regional pain syndrome (CRPS) in the concurrent surgical treatment of Dupuytren contracture (DC) and carpal tunnel syndrome (CTS) through a thorough review of evidence available in the literature. The indices of 260 hand surgery books and PubMed were searched for concomitant references to DC and CTS. Studies were eligible for inclusion if they evaluated the...
Plastic and Reconstructive Surgery; Lalonde DH
Mar 28th, 2019 - Discussion: Collagenase Clostridium Histolyticum for Dupuytren Contracture: Comparing Single and Concurrent Injections.|2019|Lalonde DH,|
Hand (New York, N.Y.); Wozniczka J, Canepa C et. al.
Jun 21st, 2017 - Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. This study describes ...
Journal of Ultrasound in Medicine : Official Journal of T... Morris G, Jacobson JA et. al.
Jul 21st, 2018 - To retrospectively characterize the ultrasound appearance of palmar fibromatosis in patients with a surgical or clinical diagnosis of palmar fibromatosis. A search of ultrasound reports from 2005 to 2015 and a subsequent search of medical records were performed to identify patients with a surgical or clinical diagnosis of palmar fibromatosis. The ultrasound images were retrospectively reviewed ...
Hand Clinics; Dias JJ, Aziz S
Jul 17th, 2018 - This article discusses limited fasciectomy for Dupuytren contracture, reviews the literature to list common complications, addresses the observations that need to be made after surgery, and systematically reviews the literature for 2 clinical questions: (1) regarding leaving wounds open and (2) the use of postoperative splintage.