×
About 494 results

ALLMedicine™ Acetaminophen Toxicity Center

Research & Reviews  227 results

N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental ...
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.

Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...

A potential role for SerpinA3N in acetaminophen-induced hepatotoxicity.
https://doi.org/10.1124/molpharm.120.000117
Molecular Pharmacology; Tran M, Wu J et. al.

Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliver but is also the most frequent cause of drug induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, while mechanisms of hepatotoxicity are not w...

Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.

Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...

Successful orthotopic liver transplantation in a patient with a positive SARS-CoV2 test...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675719
American Journal of Transplantation : Official Journal Of... Rouphael C, D'Amico G et. al.

Oct 5th, 2020 - SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization in March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, on managing patients with COVID-19,...

Models of Idiosyncratic Drug-Induced Liver Injury.
https://doi.org/10.1146/annurev-pharmtox-030220-015007
Annual Review of Pharmacology and Toxicology; Yokoi T, Oda S

Sep 25th, 2020 - Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages of drug development and after a drug is marketed. DILI is generally classified as either intrinsic or idiosyncratic. Intrinsic DILI is dose dependent...

see more →

Guidelines  2 results

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

FAQs on Acetaminophen Use During Pregnancy
www.teratology.org/pdf/Acetaminophen FAQ March 2014.pdf
Teratology Society

Feb 28th, 2014 - A recent article in JAMA (Journal of the American Medical Association) ? Pediatrics reported an increased risk of attention deficit hyperactive disorder (ADHD) and related behavioral problems in children whose mothers took acetaminophen during pre.

see more →

Drugs  1 results see all →

Clinicaltrials.gov  243 results

N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental ...
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.

Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...

A potential role for SerpinA3N in acetaminophen-induced hepatotoxicity.
https://doi.org/10.1124/molpharm.120.000117
Molecular Pharmacology; Tran M, Wu J et. al.

Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliver but is also the most frequent cause of drug induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, while mechanisms of hepatotoxicity are not w...

Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.

Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...

Successful orthotopic liver transplantation in a patient with a positive SARS-CoV2 test...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675719
American Journal of Transplantation : Official Journal Of... Rouphael C, D'Amico G et. al.

Oct 5th, 2020 - SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization in March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, on managing patients with COVID-19,...

Models of Idiosyncratic Drug-Induced Liver Injury.
https://doi.org/10.1146/annurev-pharmtox-030220-015007
Annual Review of Pharmacology and Toxicology; Yokoi T, Oda S

Sep 25th, 2020 - Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages of drug development and after a drug is marketed. DILI is generally classified as either intrinsic or idiosyncratic. Intrinsic DILI is dose dependent...

see more →

News  21 results

Acute Liver Failure in a 64-Year-Old Man
https://reference.medscape.com/viewarticle/911040_5

Mar 28th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

Acute liver failure in the ED
https://www.mdedge.com/internalmedicine/article/143261/liver-disease/acute-liver-failure-ed
Jennie Smith

Jul 25th, 2017 - Acute liver failure (ALF), is a life-threatening deterioration of liver function in people without preexisting cirrhosis. It can be caused by acetaminophen toxicity, pregnancy, ischemia, hepatitis A infection, and Wilson disease, among other thing.

VIDEO: Point-of-care assay caught acetaminophen toxicity
https://www.mdedge.com/internalmedicine/article/132476/hepatology/video-point-care-assay-caught-acetaminophen-toxicity
Amy Karon

Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.

Acetaminophen Liver Failure Least Likely to Get Transplant
https://www.mdedge.com/internalmedicine/article/56694/gastroenterology/acetaminophen-liver-failure-least-likely-get
Jeff Evans

Nov 12th, 2012 - BOSTON – Acetaminophen toxicity is the most frequent cause of acute liver failure in the United States and its usually milder presentation, along with comorbid psychosocial issues, explain why fewer patients with the etiology undergo liver transpl.

see more →