ALLMedicine™ Acetaminophen Toxicity Center
Research & Reviews 227 results
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.
Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...
https://doi.org/10.1124/molpharm.120.000117
Molecular Pharmacology; Tran M, Wu J et. al.
Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliver but is also the most frequent cause of drug induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, while mechanisms of hepatotoxicity are not w...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.
Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675719
American Journal of Transplantation : Official Journal Of... Rouphael C, D'Amico G et. al.
Oct 5th, 2020 - SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization in March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, on managing patients with COVID-19,...
https://doi.org/10.1146/annurev-pharmtox-030220-015007
Annual Review of Pharmacology and Toxicology; Yokoi T, Oda S
Sep 25th, 2020 - Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages of drug development and after a drug is marketed. DILI is generally classified as either intrinsic or idiosyncratic. Intrinsic DILI is dose dependent...
Guidelines 2 results
https://www.ncbi.nlm.nih.gov/books/NBK441917/
Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...
www.teratology.org/pdf/Acetaminophen FAQ March 2014.pdf
Teratology Society
Feb 28th, 2014 - A recent article in JAMA (Journal of the American Medical Association) ? Pediatrics reported an increased risk of attention deficit hyperactive disorder (ADHD) and related behavioral problems in children whose mothers took acetaminophen during pre.
Drugs 1 results see all →
Clinicaltrials.gov 243 results
https://doi.org/10.1080/15563650.2021.1874405
Clinical Toxicology (Philadelphia, Pa.); McDougall G, Murphy NG et. al.
Feb 2nd, 2021 - We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NA...
https://doi.org/10.1124/molpharm.120.000117
Molecular Pharmacology; Tran M, Wu J et. al.
Jan 13th, 2021 - Acetaminophen (APAP) is a commonly used pain and fever reliver but is also the most frequent cause of drug induced liver injury. The mechanism pertaining acetaminophen toxicity has been well documented, while mechanisms of hepatotoxicity are not w...
https://doi.org/10.1016/j.yrtph.2020.104859
Regulatory Toxicology and Pharmacology : RTP; Jaeschke H, Murray FJ et. al.
Jan 3rd, 2021 - In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA) initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this review, herein we evaluated the mechanistic data related to the steps and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675719
American Journal of Transplantation : Official Journal Of... Rouphael C, D'Amico G et. al.
Oct 5th, 2020 - SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization in March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, on managing patients with COVID-19,...
https://doi.org/10.1146/annurev-pharmtox-030220-015007
Annual Review of Pharmacology and Toxicology; Yokoi T, Oda S
Sep 25th, 2020 - Drug-induced liver injury (DILI) is a leading cause of attrition during the early and late stages of drug development and after a drug is marketed. DILI is generally classified as either intrinsic or idiosyncratic. Intrinsic DILI is dose dependent...
News 21 results
https://reference.medscape.com/viewarticle/911040_5
Mar 28th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...
https://www.ncbi.nlm.nih.gov/books/NBK441917/
Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...
https://www.mdedge.com/internalmedicine/article/143261/liver-disease/acute-liver-failure-ed
Jennie Smith
Jul 25th, 2017 - Acute liver failure (ALF), is a life-threatening deterioration of liver function in people without preexisting cirrhosis. It can be caused by acetaminophen toxicity, pregnancy, ischemia, hepatitis A infection, and Wilson disease, among other thing.
https://www.mdedge.com/internalmedicine/article/132476/hepatology/video-point-care-assay-caught-acetaminophen-toxicity
Amy Karon
Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.
https://www.mdedge.com/internalmedicine/article/56694/gastroenterology/acetaminophen-liver-failure-least-likely-get
Jeff Evans
Nov 12th, 2012 - BOSTON – Acetaminophen toxicity is the most frequent cause of acute liver failure in the United States and its usually milder presentation, along with comorbid psychosocial issues, explain why fewer patients with the etiology undergo liver transpl.