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About 458 results

ALLMedicine™ Acetaminophen Toxicity Center

Research & Reviews  217 results

Possible role for acetylcysteine as a treatment for acute liver failure secondary to an...
https://doi.org/10.1093/ajhp/zxaa202
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists; Fox AN, Nation BE et. al.

Sep 4th, 2020 - Drug-induced liver injury (DILI) that progresses to acute liver failure (ALF) has a high mortality rate, and therapeutic options are limited. Acetylcysteine has a labeled indication for use as an antidote for acetaminophen toxicity and has also be...

Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxic...
https://doi.org/10.12788/jhm.3447
Journal of Hospital Medicine; Hall B, Wilson K et. al.

Aug 27th, 2020 - Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity.|2020|Hall B,Wilson K,Blind F,|

A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Ac...
https://doi.org/10.1007/s13181-020-00804-5
Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology; Epperson LC, Weiss ST et. al.

Aug 20th, 2020 - Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose. Most reactions are mild, occurring within the first 1-5 hours of initiatio...

Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451831
Pediatric Research; Buhimschi CS, Bahtiyar MO et. al.

Aug 20th, 2020 - Intrauterine infection and/or inflammation (Triple I) is an important cause of preterm birth (PTB) and adverse newborn outcomes. N-acetylcysteine (NAC) is a Food and Drug Administration (FDA)-approved drug safely administered to pregnant women wit...

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for parace...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415487
Archives of Toxicology; Koenderink JB, van den Heuvel JJMW et. al.

May 30th, 2020 - Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathio...

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Guidelines  2 results

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

FAQs on Acetaminophen Use During Pregnancy
www.teratology.org/pdf/Acetaminophen FAQ March 2014.pdf
Teratology Society

Feb 28th, 2014 - A recent article in JAMA (Journal of the American Medical Association) ? Pediatrics reported an increased risk of attention deficit hyperactive disorder (ADHD) and related behavioral problems in children whose mothers took acetaminophen during pre.

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Drugs  1 results see all →

Clinicaltrials.gov  225 results

Possible role for acetylcysteine as a treatment for acute liver failure secondary to an...
https://doi.org/10.1093/ajhp/zxaa202
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists; Fox AN, Nation BE et. al.

Sep 4th, 2020 - Drug-induced liver injury (DILI) that progresses to acute liver failure (ALF) has a high mortality rate, and therapeutic options are limited. Acetylcysteine has a labeled indication for use as an antidote for acetaminophen toxicity and has also be...

Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxic...
https://doi.org/10.12788/jhm.3447
Journal of Hospital Medicine; Hall B, Wilson K et. al.

Aug 27th, 2020 - Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity.|2020|Hall B,Wilson K,Blind F,|

A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Ac...
https://doi.org/10.1007/s13181-020-00804-5
Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology; Epperson LC, Weiss ST et. al.

Aug 20th, 2020 - Anaphylactoid reactions are well-documented adverse events associated with the intravenous administration of N-acetylcysteine (NAC) in patients with acetaminophen overdose. Most reactions are mild, occurring within the first 1-5 hours of initiatio...

Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451831
Pediatric Research; Buhimschi CS, Bahtiyar MO et. al.

Aug 20th, 2020 - Intrauterine infection and/or inflammation (Triple I) is an important cause of preterm birth (PTB) and adverse newborn outcomes. N-acetylcysteine (NAC) is a Food and Drug Administration (FDA)-approved drug safely administered to pregnant women wit...

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for parace...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415487
Archives of Toxicology; Koenderink JB, van den Heuvel JJMW et. al.

May 30th, 2020 - Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathio...

see more →

News  13 results

Acetaminophen Toxicity - StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK441917/

Nov 13th, 2018 - Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is common primarily because the medication is so readily available and there is a perception that it is very safe. More than 60 million Americans consume acetaminophen on a week...

Acute liver failure in the ED
https://www.mdedge.com/internalmedicine/article/143261/liver-disease/acute-liver-failure-ed
Jennie Smith

Jul 25th, 2017 - Acute liver failure (ALF), is a life-threatening deterioration of liver function in people without preexisting cirrhosis. It can be caused by acetaminophen toxicity, pregnancy, ischemia, hepatitis A infection, and Wilson disease, among other thing.

VIDEO: Point-of-care assay caught acetaminophen toxicity
https://www.mdedge.com/internalmedicine/article/132476/hepatology/video-point-care-assay-caught-acetaminophen-toxicity
Amy Karon

Mar 1st, 2017 - A rapid point-of-care assay for acetaminophen-related liver toxicity had a sensitivity of 100% and a specificity of 86%, compared with etiologic diagnosis, based on the results of a multicenter study published in the April issue of Clinical Gastro.

Acetaminophen Liver Failure Least Likely to Get Transplant
https://www.mdedge.com/internalmedicine/article/56694/gastroenterology/acetaminophen-liver-failure-least-likely-get
Jeff Evans

Nov 12th, 2012 - BOSTON – Acetaminophen toxicity is the most frequent cause of acute liver failure in the United States and its usually milder presentation, along with comorbid psychosocial issues, explain why fewer patients with the etiology undergo liver transpl.

Agent Linked to Survival of Children with Acute Liver Failure
https://www.medpagetoday.com/gastroenterology/generalhepatology/7855

Jan 4th, 2008 - Action Points Explain that the study found that survival in children with acute liver failure not resulting from acetaminophen toxicity improved following the introduction of routine N-acetylcysteine treatment. Point out that factors other than N-...

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