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ALLMedicine™ Drug-induced Hepatotoxicity Center

Research & Reviews  117 results

Unusual Recurrence of Antituberculosis Drug-Induced Hepatotoxicity in Children: A Case ...
https://doi.org/10.12659/AJCR.930828
The American Journal of Case Reports; Nataprawira HM, Aliyannissa A et. al.

Jul 17th, 2021 - BACKGROUND Antituberculosis drug-induced hepatotoxicity (ADIH) is a possible adverse event of antitubercular treatment. There are still no official guidelines for ADIH management in children. Recurrent ADIH is infrequently reported. CASE REPORT In...

A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis dr...
https://doi.org/10.1111/jcpt.13452
Journal of Clinical Pharmacy and Therapeutics; Zhu J, Liu W et. al.

May 29th, 2021 - Anti-tuberculosis (anti-TB) drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction. A recent study found that the rs2011404 variant of uridine 5'-diphospho-glucuronosyl-transferase 1A4 (UGT1A4) is a marker of susceptibility to ATDH....

Hyaluronate-functionalized hydroxyapatite nanoparticles laden with methotrexate and ter...
https://doi.org/10.1016/j.ijbiomac.2020.12.204
International Journal of Biological Macromolecules; Pandey S, Rai N et. al.

Jan 11th, 2021 - Rheumatoid arthritis (RA), an autoimmune inflammatory disorder is currently incurable. Methotrexate and Teriflunomide are routinely prescribed drugs but their uses are limited due to severe hepatotoxicity. Hyaluronic acid (HYA) is a targeting liga...

Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855998
Toxicology Davidson MD, Pickrell J et. al.

Dec 29th, 2020 - Given significant species-specific differences in liver functions, cultures of primary human hepatocytes (PHHs) are useful for assessing drug metabolism and to mitigate the risk of drug-induced hepatotoxicity in humans. While significant advances ...

Abnormal Liver Blood Tests in Patients with Hyperthyroidism: Systematic Review and Meta...
https://doi.org/10.1089/thy.2020.0715
Thyroid : Official Journal of the American Thyroid Associ... Scappaticcio L, Longo M et. al.

Dec 18th, 2020 - Background: Abnormal liver blood tests (LBTs) in hyperthyroid patients are not uncommonly encountered. One major adverse event of antithyroid drug (ATD) therapy is drug-induced hepatotoxicity. Abnormal LBT in the hyperthyroidism scenario is a main...

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Drugs  5 results see all →

Clinicaltrials.gov  2 results

Comparison of Coenzyme A and Fenofibrate for Safety and Efficacy On Patients With Hyperlipidemia
https://clinicaltrials.gov/ct2/show/NCT01878227

Jun 14th, 2013 - Although lowering cholesterol and low-density lipoprotein-cholesterol (LDL-C) is the mainstay of medical therapy for cardiovascular event prevention, evidence from clinical trials supports a role for elevated triglyceride (TG) and low high-density...

Reintroduction Regimens After Hepatitis During Anti-tuberculosis Treatment
https://clinicaltrials.gov/ct2/show/NCT01395654

Dec 27th, 2012 - Tuberculosis (TB) remains a leading health problem in both developing and developed countries. Despite the availability of effective chemotherapeutic agents that exist to treat this illness, hepatotoxicity during first-line drugs anti-tuberculosis...

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News  8 results

Be Wary of Liver Injury From Herbals or Dietary Supplements
https://www.medscape.com/viewarticle/896051

May 7th, 2018 - Dietary supplements are regarded by the US Food and Drug Administration (FDA) as a food but not as a drug. The use of herbal and dietary supplements is common in the United States, with surveys suggesting that up to 50% of adults use them, and sal...

Hepatitis C to Take Center Stage at the Liver Meeting
https://www.medscape.com/viewarticle/813296

Oct 28th, 2013 - With its major focus on hepatitis C screening and treatment, perhaps it's fitting that the Liver Meeting 2013 is taking place in Washington, DC, for the very first time, where just last week an advisory panel to the US Food and Drug Administration...

NSAIDs: Balancing the Risks and Benefits
https://www.medscape.com/viewarticle/863463_6

Hepatotoxicity Risk About 10% of total drug-induced hepatotoxicity is NSAIDrelated.[21] A review of NSAID-induced hepatotoxicity by Bessone concluded that ibuprofen has the best liver safety profile out of all prescription and OTC NSAIDs, while su...

Hepatotoxic Effects of Lipid-altering Agents
https://www.medscape.com/viewarticle/773600_2

Clinical Presentation Drug-induced hepatotoxicity secondary to lipid-altering agents includes acute liver failure, hepatitis, cholestasis, and most commonly transaminitis, an asymptomatic elevation in serum transaminases.[3] Acute liver failure is...

Hepatotoxic Effects of Lipid-altering Agents
https://www.medscape.com/viewarticle/773600

Introduction Dyslipidemia is a major risk factor for coronary heart disease (CHD), and current guidelines support low-density lipoprotein cholesterol (LDL-C) as a primary target of therapy.[1] Previous studies suggest that increasing high-density ...

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