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About 676 results

ALLMedicine™ Drug-induced Hepatotoxicity Center

Research & Reviews  333 results

Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855998
Toxicology Davidson MD, Pickrell J et. al.

Dec 28th, 2020 - Given significant species-specific differences in liver functions, cultures of primary human hepatocytes (PHHs) are useful for assessing drug metabolism and to mitigate the risk of drug-induced hepatotoxicity in humans. While significant advances ...

Abnormal Liver Blood Tests in Patients with Hyperthyroidism: Systematic Review and Meta...
https://doi.org/10.1089/thy.2020.0715
Thyroid : Official Journal of the American Thyroid Associ... Scappaticcio L, Longo M et. al.

Dec 17th, 2020 - Background: Abnormal liver blood tests (LBTs) in hyperthyroid patients are not uncommonly encountered. One major adverse event of antithyroid drug (ATD) therapy is drug-induced hepatotoxicity. Abnormal LBT in the hyperthyroidism scenario is a main...

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891502
Journal of Clinical Laboratory Analysis; Cheng Y, Jiao L et. al.

Dec 9th, 2020 - The role of collagen type XVIII alpha 1 chain (COL18A1) in anti-tuberculosis drug-induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility. A total of 746 ...

Alanine transaminase and hemoglobin appear to predict the occurrence of antituberculosi...
https://doi.org/10.1080/14787210.2020.1822735
Expert Review of Anti-infective Therapy; Kesenogile B, Godman B et. al.

Sep 10th, 2020 - Tuberculosis (TB) remains a global health problem, with medications having adverse effects including drug-induced hepatotoxicity. We determined the prevalence of anti-tuberculosis drug-induced hepatotoxicity and associated risk factors. Retrospect...

Evidence of drug-induced hepatotoxicity in the Maghrebian population.
https://doi.org/10.1080/01480545.2020.1797088
Drug and Chemical Toxicology; Bourhia M, Ullah R et. al.

Jul 25th, 2020 - Drug-induced hepatotoxicity is one of the most challenging hepatic diseases faced nowadays due to a large number of drugs currently used in clinical practice, the enormous dietary supplements which are potentially hepatotoxic, as well as the abili...

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Clinicaltrials.gov  339 results

Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855998
Toxicology Davidson MD, Pickrell J et. al.

Dec 28th, 2020 - Given significant species-specific differences in liver functions, cultures of primary human hepatocytes (PHHs) are useful for assessing drug metabolism and to mitigate the risk of drug-induced hepatotoxicity in humans. While significant advances ...

Abnormal Liver Blood Tests in Patients with Hyperthyroidism: Systematic Review and Meta...
https://doi.org/10.1089/thy.2020.0715
Thyroid : Official Journal of the American Thyroid Associ... Scappaticcio L, Longo M et. al.

Dec 17th, 2020 - Background: Abnormal liver blood tests (LBTs) in hyperthyroid patients are not uncommonly encountered. One major adverse event of antithyroid drug (ATD) therapy is drug-induced hepatotoxicity. Abnormal LBT in the hyperthyroidism scenario is a main...

Collagen type XVIII alpha 1 chain (COL18A1) variants affect the risk of anti-tuberculos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891502
Journal of Clinical Laboratory Analysis; Cheng Y, Jiao L et. al.

Dec 9th, 2020 - The role of collagen type XVIII alpha 1 chain (COL18A1) in anti-tuberculosis drug-induced hepatotoxicity (ATDH) has not been reported. This study aimed to explore the association between of COL18A1 variants and ATDH susceptibility. A total of 746 ...

Alanine transaminase and hemoglobin appear to predict the occurrence of antituberculosi...
https://doi.org/10.1080/14787210.2020.1822735
Expert Review of Anti-infective Therapy; Kesenogile B, Godman B et. al.

Sep 10th, 2020 - Tuberculosis (TB) remains a global health problem, with medications having adverse effects including drug-induced hepatotoxicity. We determined the prevalence of anti-tuberculosis drug-induced hepatotoxicity and associated risk factors. Retrospect...

Evidence of drug-induced hepatotoxicity in the Maghrebian population.
https://doi.org/10.1080/01480545.2020.1797088
Drug and Chemical Toxicology; Bourhia M, Ullah R et. al.

Jul 25th, 2020 - Drug-induced hepatotoxicity is one of the most challenging hepatic diseases faced nowadays due to a large number of drugs currently used in clinical practice, the enormous dietary supplements which are potentially hepatotoxic, as well as the abili...

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News  4 results

Three Severe Liver Damage Cases Linked to Ketolide Antibiotic
https://www.medpagetoday.com/gastroenterology/generalhepatology/2525

Jan 20th, 2006 - Action Points Note that this case report describes three cases of severe liver toxicity that appear to be associated with the use of Ketek (telithromycin); the cases include one patient who died and one who required a liver transplant. Advise pati...

Hepatic toxicity of antirheumatic drugs
https://www.mdedge.com/ccjm/article/92787/hepatic-toxicity-antirheumatic-drugs

Abstract BACKGROUND Many of the diverse group of pharmacologic agents available for the treatment of rheumatic diseases have the potential to cause serious hepatotoxicity. OBJECTIVE To identify factors associated with drug-induced hepatotoxicity in.

NSAIDs: Balancing the Risks and Benefits
https://www.medscape.com/viewarticle/863463_6

Hepatotoxicity Risk About 10% of total drug-induced hepatotoxicity is NSAIDrelated.[21] A review of NSAID-induced hepatotoxicity by Bessone concluded that ibuprofen has the best liver safety profile out of all prescription and OTC NSAIDs, while su...

Hepatotoxic Effects of Lipid-altering Agents
https://www.medscape.com/viewarticle/773600_2

Clinical Presentation Drug-induced hepatotoxicity secondary to lipid-altering agents includes acute liver failure, hepatitis, cholestasis, and most commonly transaminitis, an asymptomatic elevation in serum transaminases.[3] Acute liver failure is...

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