About 1,320 results

ALLMedicine™ Hyperammonemia Center

Research & Reviews  481 results

Nonhepatic hyperammonemic encephalopathy complications following bariatric surgery: a c...
Journal of Medical Case Reports; Vinegrad N, Staretz-Chacham O et. al.

Jul 21st, 2021 - Hyperammonemic encephalopathy, a rare but fatal condition, is increasingly being reported as a possible complication of bariatric surgery. Here, we present a case of hyperammonemic encephalopathy, focusing on the clinical presentation, diagnostic ...

Lethal hyperammonemia in a CAR-T cell recipient due to Ureaplasma pneumonia: a case rep...
BMJ Case Reports; Tawfik P, Arndt P

Jul 11th, 2021 - We report the first incidence of Ureaplasma infection causing lethal hyperammonemia in a chimeric receptor antigen T cell (CAR-T) recipient. A 53-year-old woman, after receiving CAR-T therapy, suffered sepsis and encephalopathy. She was found to h...

Role of liver transplantation in urea cycle disorders: Report from a nationwide study i...
Journal of Inherited Metabolic Disease; Kido J, Matsumoto S et. al.

Jul 8th, 2021 - Urea cycle disorders (UCDs) are inherited metabolic diseases causing hyperammonemia by defects in urea cycle enzymes or transporters. Liver transplantation (LT) currently is the only curative treatment option until novel therapies become available...

Whole brain atlas-based diffusion kurtosis imaging parameters for evaluation of minimal...
The Neuroradiology Journal; Gupta P, Vyas S et. al.

Jul 1st, 2021 - Minimal hepatic encephalopathy (MHE) has no recognizable clinical symptoms, but patients have cognitive and psychomotor deficits. Hyperammonemia along with neuroinflammation lead to microstructural changes in cerebral parenchyma. Changes at conven...

Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People...
CNS Spectrums; Mazzoglio Y Nabar MJ, Muñoz S et. al.

Jun 16th, 2021 - Hyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living wit...

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Guidelines  1 results

Extracorporeal treatment for valproic acid poisoning: systematic review and recommendat...
Clinical Toxicology (Philadelphia, Pa.); Ghannoum M, Laliberté M et. al.

May 8th, 2015 - The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning. The lead authors reviewed all of the articles...

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Drugs  22 results see all →

Clinicaltrials.gov  10 results

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE)

Aug 21st, 2018 - Multicenter, Randomized Phase 2B Study to Evaluate the Efficacy, Safety and Tolerability of OCR-002 (ornithine phenylacetate) in Hospitalized Patients with Cirrhosis and Associated Hyperammonemia with an Episode of Hepatic Encephalopathy (STOP-HE ...

Genetic and Metabolic Disease in Children

May 2nd, 2018 - Discovery of genetic basis of impaired metabolism has greatly advanced treatment of patients with known metabolic diseases. However, many more genetic and metabolic disorders and their molecular causes remain to be discovered. The overall goal of ...

Orphan Europe Carbaglu® Surveillance Protocol

Jan 24th, 2018 - Among the urea cycle disorders, N-acetylglutamate synthase (NAGS) deficiency is the rarest type. In 2010, carglumic acid (Carabglu) was approved by the United States Food and Drug Administration (FDA) "as an adjunctive therapy for the treatment of...

Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD

Jan 18th, 2018 - Argininosuccinate lyase deficiency (ASLD; also known as argininosuccinic aciduria) is the second most common urea cycle disorder (UCD) and accounts for 15-20% of all disorders of ureagenesis. Individuals with ASLD can have unique clinical and phys...

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia

Oct 6th, 2017 - This is a double-blind, placebo-controlled, randomized clinical drug trial to evaluate the efficacy of NCG in the treatment of two organic acidemias (severe PA and MMA), and two urea-cycle disorders (late-onset CPSD and OTCD). Primarily, the inves...

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News  14 results

Hyperammonemia in Children With Kidney Replacement Therapy Clinical Practice Guidelines (2020)

May 29th, 2020 - In April 2020, the Pediatric Continuous Renal Replacement Therapy Workgroup published their recommendations for the management of hyperammonemia in pediatric patients receiving continuous kidney replacement therapy.[1] Medical Therapy for Hyperamm...

Microbiome – Impact on health and disease
Gary D. Wu, MD

Jul 15th, 2019 - The gut microbiota influences our biology through our mucosal immune system as well as by leading to the production of bioactive small molecules. I’ll describe how gut microbiota influences colon cancer, liver disease, the production of bioactive.

Winners all

Dec 3rd, 2018 - Case Report Slide Winners Ze Ying Tan: All that wheezes is not asthma Jason Lam: Pulmonary mucor mycetoma Adam Young: Nonresolving pneumonia and cyclic fevers in an immunocompetent patient Ritu Modi: Histopathological misdiagnosis of pulmonary coc.

Rising microbiome investigator: Ting-Chin David Shen, MD, PhD

Sep 28th, 2018 - We spoke with Dr. Shen, instructor of medicine at the University of Pennsylvania and the recipient of the AGA Research Foundation’s 2016 Microbiome Junior Investigator Award, to learn about his passion for gut microbiome research.

Rare Disease Treatments Make Up Top 10 Most Costly Drugs

May 2nd, 2017 - UPDATED May 4, 2017 // The world's top 10 most expensive drugs are all orphan drugs for rare and ultrarare diseases, according to a new analysis. Leading that pack at number 1 is glycerol phenylbutyrate (Ravicti, Horizon Pharma), an orphan drug ap...

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