×
About 323 results

ALLMedicine™ Iron Toxicity Center

Research & Reviews  159 results

Iron induces cell death and strengthens the efficacy of anti-androgen therapy in prosta...
https://doi.org/10.1158/1078-0432.CCR-20-3182
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research; Bordini J, Morisi F et. al.

Sep 15th, 2020 - In search of novel strategies to improve the outcome of advanced prostate cancer (PCa), we considered that PCa cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing PCa preclinical model...

Neutrophils from hereditary hemochromatosis patients are protected from iron excess and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448602
Blood Advances; Renassia C, Louis S et. al.

Aug 18th, 2020 - Iron is required for the oxidative response of neutrophils to allow the production of reactive oxygen species (ROS). However, neutrophil function may be severely altered in conditions of iron overload, as observed in chronically transfused patient...

Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259719
PloS One; Lertsuwan K, Nammultriputtar K et. al.

May 29th, 2020 - One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were...

How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?
https://doi.org/10.1080/17474086.2020.1719359
Expert Review of Hematology; Kontoghiorghes GJ

Feb 7th, 2020 - How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?|2020|Kontoghiorghes GJ,|

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial ...
https://doi.org/10.1016/j.nbd.2020.104786
Neurobiology of Disease; Anand N, Holcom A et. al.

Feb 7th, 2020 - Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced ne...

see more →

Clinicaltrials.gov  161 results

Iron induces cell death and strengthens the efficacy of anti-androgen therapy in prosta...
https://doi.org/10.1158/1078-0432.CCR-20-3182
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research; Bordini J, Morisi F et. al.

Sep 15th, 2020 - In search of novel strategies to improve the outcome of advanced prostate cancer (PCa), we considered that PCa cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing PCa preclinical model...

Neutrophils from hereditary hemochromatosis patients are protected from iron excess and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448602
Blood Advances; Renassia C, Louis S et. al.

Aug 18th, 2020 - Iron is required for the oxidative response of neutrophils to allow the production of reactive oxygen species (ROS). However, neutrophil function may be severely altered in conditions of iron overload, as observed in chronically transfused patient...

Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, de...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259719
PloS One; Lertsuwan K, Nammultriputtar K et. al.

May 29th, 2020 - One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were...

How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?
https://doi.org/10.1080/17474086.2020.1719359
Expert Review of Hematology; Kontoghiorghes GJ

Feb 7th, 2020 - How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?|2020|Kontoghiorghes GJ,|

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial ...
https://doi.org/10.1016/j.nbd.2020.104786
Neurobiology of Disease; Anand N, Holcom A et. al.

Feb 7th, 2020 - Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced ne...

see more →

News  3 results

Will We Make Artificial Blood Soon? (STAT)
https://www.medpagetoday.com/criticalcare/intensivists/63444

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Study challenges previous notions about RBC disposal
https://www.mdedge.com/hematology-oncology/article/187203/anemia/study-challenges-previous-notions-about-rbc-disposal
HT Staff

Jul 19th, 2016 - Red blood cells A new study contradicts previous beliefs about how the body disposes of red blood cells (RBCs) and recycles their iron. The work suggests the accumulation and removal of aged or damaged RBCs largely takes place in the liver rather.

see more →