ALLMedicine™ Acetaminophen Toxicity Center

Mar 8th, 2023 - In January 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by March 2014. To asses...

Feb 1st, 2023 - BACKGROUND Fulminant hepatic failure (FHF) is commonly associated with elevated prothrombin time (PT) and international normalized ratio (INR). There is a commensurate decline in pro- and anti-hemostatic factors, and hemostatic function is rebalan...

Jan 5th, 2023 - Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment. It is recognized that the gut ma...

Nov 25th, 2022 - Although N-acetyl-cysteine (NAC) has long been used for the treatment of acetaminophen poisoning/overdose, the optimal NAC dosing regimen for varying patterns or severity of the poisoning/overdose is still unknown. Relevant literature was searched...

Nov 18th, 2022 - Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells forming the hepatic sinusoidal wall. Besides their high endocytic potential, LSECs have been demonstrated to markedly contribute to liver homeostasis and immunity,...

Jan 28th, 2022 - Although ALF is truly an orphan disease affecting only about 2,000 persons per year, its severity, its frequency among young adults, and its high resource utilization justifies the attention paid to it. In addition, ALF has captured the interest a...

Aug 9th, 2021 - Introduction: Carpal tunnel syndrome (CTS) is the most prevalent and widely studied peripheral nerve entrapment syndrome, with estimates between 10-20% of the general population having clinical symptoms of CTS at least once in their lifetime. Clas...

Jun 1st, 2020 - Patients admitted to study sites with carefully defined criteria for acute liver failure and who are thought not to have acetaminophen toxicity, mushroom poisoning, pregnancy-related liver failure, or malignancy will be eligible. Each patient will...

Jan 22nd, 2019 - This study is aimed at addressing a significant void in the current literature regarding nasally administered acetaminophen pharmacokinetics. The pharmacokinetics of acetaminophen following oral and rectal administration have been well studied but...

Nov 24th, 2017 - This study is a non-intervention, multicenter study to address biomarkers of acetaminophen toxicity in children. Specifically, the study will examine acetaminophen (APAP) protein adducts and markers of liver injury in the blood samples of hospital...

Mar 7th, 2023 - An FDA mandate limiting the amount of acetaminophen in combination with opioids in prescription products was associated with significant declines in hospitalizations due to acute liver failure (ALF), according to an analysis of national medical da...

Jul 22nd, 2021 - Acetaminophen is one of the most commonly used oral analgesic and antipyretic agents, with as many as 23% of US adults using an acetaminophen-containing medicine each week. It has an excellent safety profile when administered in proper therapeutic...

Mar 29th, 2019 - Various treatment protocols for acetaminophen toxicity are available, depending on the institution and the poison control center. For intravenous treatment (used in pregnant women, altered mental status, acetaminophen-induced liver failure, and in...

Mar 19th, 2018 - A 54-year-old woman presents with severe abdominal pain lasting 3 hours. The pain came on suddenly and was 10/10 in severity.

Jul 25th, 2017 - Acute liver failure (ALF), is a life-threatening deterioration of liver function in people without preexisting cirrhosis. It can be caused by acetaminophen toxicity, pregnancy, ischemia, hepatitis A infection, and Wilson disease, among other thing.