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ALLMedicine™ Drug-induced Hepatotoxicity Center

Research & Reviews  140 results

Drug-Induced Hepatotoxicity
https://emedicine.medscape.com/article/169814-print

Jul 8th, 2022 - Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosync...

Drug-Induced Hepatotoxicity
http://emedicine.medscape.com/article/169814-overview

Jul 8th, 2022 - Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the...

Drug-Induced Hepatotoxicity
https://emedicine.medscape.com/article/169814-overview

Jul 8th, 2022 - Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the...

NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruv...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356556
Molecular Genetics & Genomic Medicine; Jaramillo-Valverde L, Levano KS et. al.

Jun 26th, 2022 - In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%-13% is associated with significant adverse drug reactions (ADR), considering drug-induced liver injury (DILI) as the most prevalent. Amo...

NAT2 polymorphism and clinical factors that increase antituberculosis drug-induced hepa...
https://doi.org/10.2217/pgs-2022-0022
Pharmacogenomics Mohamed Noor NF, Salleh MZ et. al.

May 27th, 2022 - Aim: Hepatotoxicity is a known adverse effect of antituberculosis drugs. The NAT2 gene polymorphism has been associated with an increased risk of antituberculosis drug-induced hepatotoxicity (ATDIH). Materials & methods: This study investigates th...

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Drugs  8 results see all →

Clinicaltrials.gov  6 results

The Protective Effect for Liver Organ in Patients With Anti-TB Drugs Using of Acetylcysteine (NAC)
https://clinicaltrials.gov/ct2/show/NCT02889757

Sep 13th, 2016 - Isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA), the first-line drugs used for tuberculosis (TB) chemotherapy, are associated with hepatotoxicity. A high rate of hepatotoxicity has been reported in some developing countries compared with...

The Effects of Coenzyme A Combined With Statin on Serum Lipids in Patients With Hyperlipidemia
https://clinicaltrials.gov/ct2/show/NCT01928342

Aug 23rd, 2013 - Although lowering cholesterol and low-density lipoprotein-cholesterol (LDL-C) is the mainstay of medical therapy for cardiovascular event prevention, evidence from clinical trials supports a role for elevated triglyceride (TG) and low high-density...

Comparison of Coenzyme A and Fenofibrate for Safety and Efficacy On Patients With Hyperlipidemia
https://clinicaltrials.gov/ct2/show/NCT01878227

Jun 14th, 2013 - Although lowering cholesterol and low-density lipoprotein-cholesterol (LDL-C) is the mainstay of medical therapy for cardiovascular event prevention, evidence from clinical trials supports a role for elevated triglyceride (TG) and low high-density...

Reintroduction Regimens After Hepatitis During Anti-tuberculosis Treatment
https://clinicaltrials.gov/ct2/show/NCT01395654

Dec 27th, 2012 - Tuberculosis (TB) remains a leading health problem in both developing and developed countries. Despite the availability of effective chemotherapeutic agents that exist to treat this illness, hepatotoxicity during first-line drugs anti-tuberculosis...

Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity
https://clinicaltrials.gov/ct2/show/NCT01456845

Aug 31st, 2012 - Tuberculosis (TB) is a major health problem in both the developing and developed countries because of its resurgence in the immunosuppressed patients. World Health Organization (WHO) in 1993 declared tuberculosis to be a 'global emergency' with mo...

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News  11 results

Results of Laboratory Monitoring in Patients Taking Isotretinoin for Acne
https://www.mdedge.com/dermatology/article/242754/acne/results-laboratory-monitoring-patients-taking-isotretinoin-acne
Mohammed Al-Haddab, MD, FRCPC, Alanoud Alhuqayl, MD et. al.

Jul 9th, 2021 - Introduced in 1982, isotretinoin is a retinoid derivative that has been widely used to treat various dermatologic conditions such as acne vulgaris, rosacea, hidradenitis suppurativa, and hair folliculitis. 1 It remains one of the most effective dr.

Maintenance Rucaparib Extended PFS in Women with Platinum-Sensitive Recurrent Ovarian Cancer
https://www.onclive.com/view/maintenance-rucaparib-extended-pfs-in-women-with-platinumsensitive-recurrent-ovarian-cancer

Dec 20th, 2020 - Jonathan Ledermann MD, FRCP Rucaparib (Rubraca) delayed disease recurrence in the intent to treat (ITT) population and across subgroups of women with ovarian cancer, according to findings presented at the 2017 international meeting of the Europea...

Drug-Induced Liver Injury Clinical Practice Guidelines (2019)
https://reference.medscape.com/viewarticle/912596

May 6th, 2019 - Guidelines for drug-induced liver injury were published in March 2019 by the European Association for the Study of the Liver.[1] Diagnosis Classify drug-induced liver injury (DILI) as hepatocellular, cholestatic, or mixed according to the pattern ...

Be Wary of Liver Injury From Herbals or Dietary Supplements
https://www.medscape.com/viewarticle/896051

May 7th, 2018 - Dietary supplements are regarded by the US Food and Drug Administration (FDA) as a food but not as a drug. The use of herbal and dietary supplements is common in the United States, with surveys suggesting that up to 50% of adults use them, and sal...

How to modify psychotropic therapy for patients who have liver dysfunction
https://www.mdedge.com/psychiatry/article/88951/practice-management/how-modify-psychotropic-therapy-patients-who-have-liver
Shadi Doroudgar, PharmD, Tony I. Chou, PharmD, BCPP

Nov 24th, 2014 - Police bring Ms. R, age 35, to the psychiatric ER after they find her asleep in a park.

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