ALLMedicine™ Drug-induced Hepatotoxicity Center

Nov 13th, 2022 - Mycophenolate (mycophenolate mofetil [MMF]; mycophenolate sodium [MPS]) and tacrolimus (FK-506) are commonly and concomitantly used to prevent rejection in organ transplant. Mycophenolate-induced hepatotoxicity causing the reduced FK-506 metabolis...

Oct 16th, 2022 - Drug induced liver injury (DILI) or hepatotoxicity has been a hot issue to overcome on the safety and physiological function of liver, since it is known to have biochemical, cellular, immunological and molecular alterations in liver mainly induced...

Jul 8th, 2022 - Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the...

Jul 8th, 2022 - Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the...

Jul 8th, 2022 - Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosync...

Sep 13th, 2016 - Isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA), the first-line drugs used for tuberculosis (TB) chemotherapy, are associated with hepatotoxicity. A high rate of hepatotoxicity has been reported in some developing countries compared with...

Aug 23rd, 2013 - Although lowering cholesterol and low-density lipoprotein-cholesterol (LDL-C) is the mainstay of medical therapy for cardiovascular event prevention, evidence from clinical trials supports a role for elevated triglyceride (TG) and low high-density...

Jun 14th, 2013 - Although lowering cholesterol and low-density lipoprotein-cholesterol (LDL-C) is the mainstay of medical therapy for cardiovascular event prevention, evidence from clinical trials supports a role for elevated triglyceride (TG) and low high-density...

Dec 27th, 2012 - Tuberculosis (TB) remains a leading health problem in both developing and developed countries. Despite the availability of effective chemotherapeutic agents that exist to treat this illness, hepatotoxicity during first-line drugs anti-tuberculosis...

Aug 31st, 2012 - Tuberculosis (TB) is a major health problem in both the developing and developed countries because of its resurgence in the immunosuppressed patients. World Health Organization (WHO) in 1993 declared tuberculosis to be a 'global emergency' with mo...

Jul 9th, 2021 - Introduced in 1982, isotretinoin is a retinoid derivative that has been widely used to treat various dermatologic conditions such as acne vulgaris, rosacea, hidradenitis suppurativa, and hair folliculitis. 1 It remains one of the most effective dr.

Dec 20th, 2020 - Jonathan Ledermann MD, FRCP Rucaparib (Rubraca) delayed disease recurrence in the intent to treat (ITT) population and across subgroups of women with ovarian cancer, according to findings presented at the 2017 international meeting of the Europea...

May 6th, 2019 - Guidelines for drug-induced liver injury were published in March 2019 by the European Association for the Study of the Liver.[1] Diagnosis Classify drug-induced liver injury (DILI) as hepatocellular, cholestatic, or mixed according to the pattern ...

May 7th, 2018 - Dietary supplements are regarded by the US Food and Drug Administration (FDA) as a food but not as a drug. The use of herbal and dietary supplements is common in the United States, with surveys suggesting that up to 50% of adults use them, and sal...

Nov 24th, 2014 - Police bring Ms. R, age 35, to the psychiatric ER after they find her asleep in a park.