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About 1,888 results

ALLMedicine™ Hyperammonemia Center

Research & Reviews  656 results

Early allograft dysfunction in a pediatric liver allograft with an occult pathogenic mu...
https://doi.org/10.1016/j.ajt.2023.02.027
American Journal of Transplantation : Official Journal Of... Rezvani M, Campbell KM et. al.

Mar 5th, 2023 - Liver transplantation risks transferring a genetic defect in metabolic pathways, including the urea cycle. We present a case of pediatric liver transplantation complicated by metabolic crisis and early allograft dysfunction (EAD) in a previously h...

Optimalisation of the Treatment of Acute Neonatal Hyperammonaemia
https://clinicaltrials.gov/ct2/show/NCT05754372

Mar 3rd, 2023 - Acute neonatal hyperammonemia is associated with poor neurological outcomes and high mortality. A user-friendly and widely applicable algorithm - based on kinetics - to tailor the treatment of acute neonatal hyperammonemia. A single compartmental ...

Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD
https://clinicaltrials.gov/ct2/show/NCT03064048

Feb 27th, 2023 - Argininosuccinate lyase deficiency (ASLD; also known as argininosuccinic aciduria) is the second most common urea cycle disorder (UCD) and accounts for 15-20% of all disorders of ureagenesis. Individuals with ASLD can have unique clinical and phys...

Delayed recognition of autism spectrum disorder and attention-deficit/hyperactivity dis...
https://doi.org/10.1097/MD.0000000000033055
Medicine Kadono S, Miyawaki D et. al.

Feb 25th, 2023 - Ornithine transcarbamylase (OTC) deficiency, a urea cycle disorder, is a rare congenital metabolic error that leads to hyperammonemia. Psychiatric symptoms of hyperammonemia are nonspecific and can cause autism spectrum disorder (ASD)-like symptom...

Valproate-Associated Hyperammonemic Encephalopathy: Clinical Correlates and Management ...
https://doi.org/10.1097/JCP.0000000000001659
Journal of Clinical Psychopharmacology; Vaidyanathan S, Chatorikar S et. al.

Feb 17th, 2023 - Common adverse effects of valproate include sedation, tremor, gastrointestinal effects, and weight gain. Valproate-associated hyperammonemic encephalopathy (VHE) is an uncommon adverse effect of valproate therapy, which includes symptoms such as t...

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Guidelines  1 results

Extracorporeal treatment for valproic acid poisoning: systematic review and recommendat...
https://doi.org/10.3109/15563650.2015.1035441
Clinical Toxicology (Philadelphia, Pa.); Ghannoum M, Laliberté M et. al.

May 8th, 2015 - The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning. The lead authors reviewed all of the articles...

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Drugs  45 results see all →

Clinicaltrials.gov  35 results

Optimalisation of the Treatment of Acute Neonatal Hyperammonaemia
https://clinicaltrials.gov/ct2/show/NCT05754372

Mar 3rd, 2023 - Acute neonatal hyperammonemia is associated with poor neurological outcomes and high mortality. A user-friendly and widely applicable algorithm - based on kinetics - to tailor the treatment of acute neonatal hyperammonemia. A single compartmental ...

Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD
https://clinicaltrials.gov/ct2/show/NCT03064048

Feb 27th, 2023 - Argininosuccinate lyase deficiency (ASLD; also known as argininosuccinic aciduria) is the second most common urea cycle disorder (UCD) and accounts for 15-20% of all disorders of ureagenesis. Individuals with ASLD can have unique clinical and phys...

Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients
https://clinicaltrials.gov/ct2/show/NCT04246918

Jan 31st, 2023 - Reduction in muscle mass (sarcopenia) is well documented in patients with chronic liver disease (CLD)leading to increased morbidity, mortality and poor quality of life. An equilibrium is maintained between the synthesis and degradation of muscles ...

An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics
https://clinicaltrials.gov/ct2/show/NCT05040178

Dec 22nd, 2022 - This study is being conducted to obtain short-term and long-term clinical safety information from adult and pediatric patients treated for hyperammonemia due to Methylmalonic Acidemia (MMA) and Propionic Acidemia (PA). This is an observational/non...

Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome
https://clinicaltrials.gov/ct2/show/NCT03797222

Nov 25th, 2022 - Congenital hyperinsulinism (HI) is a rare disorder of pancreatic beta cell insulin secretion that causes persistent and severe hypoglycemia starting at birth. Hyperinsulinism/hyperammonemia (HI/HA) syndrome is the second most common type of congen...

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News  18 results

Cidofovir for Pediatric Adenovirus-Related Hepatitis Rapidly Reduces Viremia
https://www.medscape.com/viewarticle/976459

Jul 1st, 2022 - NEW YORK (Reuters Health) - Off-label use of cidofovir in children with acute liver failure and confirmed adenovirus infection cleared the virus or substantially reduced viremia in a small case series from Kings College Hospital, London. Dr. Avita...

Hyperammonemia in Children With Kidney Replacement Therapy Clinical Practice Guidelines (2020)
https://reference.medscape.com/viewarticle/931225

May 29th, 2020 - In April 2020, the Pediatric Continuous Renal Replacement Therapy Workgroup published their recommendations for the management of hyperammonemia in pediatric patients receiving continuous kidney replacement therapy.[1] Medical Therapy for Hyperamm...

Valproic acid-induced hyperammonemic encephalopathy
https://www.mdedge.com/psychiatry/article/214883/bipolar-disorder/valproic-acid-induced-hyperammonemic-encephalopathy
Eva Studer, MD, Tawny L. Smith, PharmD, BCPP et. al.

Jan 2nd, 2020 - Mrs. C, age 75, is transferred to our inpatient medical/surgical hospital from a psychiatric hospital after presenting with shortness of breath and altered mental status.

Microbiome – Impact on health and disease
https://www.mdedge.com/gihepnews/article/204662/liver-disease/microbiome-impact-health-and-disease?channel=346
Gary D. Wu, MD

Jul 15th, 2019 - The gut microbiota influences our biology through our mucosal immune system as well as by leading to the production of bioactive small molecules. I’ll describe how gut microbiota influences colon cancer, liver disease, the production of bioactive.

Microbiome – Impact on health and disease
https://www.mdedge.com/gihepnews/article/204662/liver-disease/microbiome-impact-health-and-disease
Gary D. Wu, MD

Jul 15th, 2019 - The gut microbiota influences our biology through our mucosal immune system as well as by leading to the production of bioactive small molecules. I’ll describe how gut microbiota influences colon cancer, liver disease, the production of bioactive.

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