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About 215 results

ALLMedicine™ Iron Toxicity Center

Research & Reviews  82 results

Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-in...
https://doi.org/10.1002/hep.32270
Hepatology (Baltimore, Md.); Xiong H, Zhang C et. al.

Dec 7th, 2021 - Iron overload is a frequent finding in the general population. As the major iron storage site, liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. We aimed to de...

Iron toxicity in intracerebral hemorrhage: Physiopathological and therapeutic implicati...
https://doi.org/10.1016/j.brainresbull.2021.11.014
Brain Research Bulletin; Wei Y, Song X et. al.

Nov 29th, 2021 - Intracerebral hemorrhage (ICH)-induced brain injury is a continuous pathological process that involves the deterioration of neurological functions, such as sensory, cognitive or motor functions. Cytotoxic byproducts of red blood cell lysis, especi...

Iron toxicity-induced regulation of key secondary metabolic processes associated with t...
https://doi.org/10.1016/j.ecoenv.2021.112648
Ecotoxicology and Environmental Safety; Wang Q, Jin Q et. al.

Aug 28th, 2021 - Panax ginseng and Panax quinquefolius can survive for long periods of time in iron toxicity-stressed environments, which cause rusty roots and reduced productivity. To reveal the proteomic changes in these two Panax species in response to iron tox...

Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364622
Seminars in Hematology; Maio N, Zhang DL et. al.

Aug 15th, 2021 - To maintain an adequate iron supply for hemoglobin synthesis and essential metabolic functions while counteracting iron toxicity, humans and other vertebrates have evolved effective mechanisms to conserve and finely regulate iron concentration, st...

Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study
https://clinicaltrials.gov/ct2/show/NCT04992975

Aug 6th, 2021 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

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Clinicaltrials.gov  2 results

Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study
https://clinicaltrials.gov/ct2/show/NCT04992975

Aug 6th, 2021 - This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzhei...

Evaluation of Oxidative Stress Induced by Iron Injection in Healthy Volunteers and Critical Care Patients
https://clinicaltrials.gov/ct2/show/NCT01443624

Aug 14th, 2013 - Anemia is frequent among critically ill patients, with 60% of the patients being anemic at admission and more than 80% at discharge. This anemia is associated with an increased MORBI-mORTALITY. However, therapeutic options, mainly transfusion and ...

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News  2 results

Will We Make Artificial Blood Soon? (STAT)
https://www.medpagetoday.com/criticalcare/intensivists/63444

Feb 27th, 2017 - Researchers have sought a blood substitute for over 150 years, and they've all failed. Now, one candidate has demonstrated promising early results, while another nears clinical trials again, reported STAT. ErythroMer encloses hemoglobin in a synth...

Excess Iron May Boost Adult Height
https://www.medpagetoday.com/hematologyoncology/hematology/41120

Aug 21st, 2013 - Action Points Patients with hemochromatosis were taller on average than those in a reference population. The deviation in height did not correlate with the type of HFE mutation, serum ferritin level, liver enzyme elevation, liver fibrosis, or clin...

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