ALLMedicine™ Opioid Toxicity Center

Mar 8th, 2023 - In January 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by March 2014. To asses...

Mar 1st, 2023 - New psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are often inadequately elucidated, which contributes to the delayed characterization of their pharmacological effects. Inspired by...

Dec 20th, 2022 - Opioids are key analgesic drugs. Unfortunately, they have a high potential for abuse with potentially lethal consequences, more specifically death due to respiratory suppression. In both Canada and the US, the number of deaths from opioid overdose...

Nov 8th, 2022 - Insights into the pathophysiology of many non-immune-mediated drug reactions referred to as toxicities, sensitivities, intolerances, or pseudoallergies have resulted from research identifying the mastocyte-related G-protein-coupled receptor (GPCR)...

Nov 8th, 2022 - Chronic pain is a devastating disease often treated inadequately. More than 30 percent of the world population suffers from chronic pain. Among a plethora of treatment options, opioid agonists is one of treatment options for moderate to severe chr...

Dec 20th, 2022 - Opioids are key analgesic drugs. Unfortunately, they have a high potential for abuse with potentially lethal consequences, more specifically death due to respiratory suppression. In both Canada and the US, the number of deaths from opioid overdose...

Nov 8th, 2022 - Chronic pain is a devastating disease often treated inadequately. More than 30 percent of the world population suffers from chronic pain. Among a plethora of treatment options, opioid agonists is one of treatment options for moderate to severe chr...

Sep 10th, 2022 - The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder. The objectives are to decrease the number of fatal and nonfatal overdose deaths, to exami...

Aug 17th, 2021 - A recent paper by Kim et al prospectively investigated opioid utilization after upper extremity surgery. This study (n=1,416) showed an opioid utilization rate of just 34%, taking an average 8.1 pills out of 24 prescribed. Patients age 30-39, thos...

Aug 1st, 2019 - This was a phase 1, single-center study carried out in healthy male and female subjects to investigate the safety, tolerability, and PK of d-methadone. This was a double-blind, randomized, placebo-controlled study in 6 sequential cohorts of health...

Mar 7th, 2023 - An FDA mandate limiting the amount of acetaminophen in combination with opioids in prescription products was associated with significant declines in hospitalizations due to acute liver failure (ALF), according to an analysis of national medical da...

Jul 7th, 2022 - People experiencing homelessness were overrepresented among those who died of substance-related acute toxicity in Canada in 2016 and 2017, according to a new report. Among those who were homeless at the time of their death, at least 1 in 10 were r...

Jul 1st, 2022 - Canada's opioid and stimulant-related death rate has reached an all-time high, according to a statement from the Public Health Agency of Canada (PHAC). The number of apparent opioid toxicity deaths increased by 96% in the first year of the pandemi...

Mar 17th, 2022 - Older adults admitted to post-acute settings frequently have complex rehabilitation needs and multimorbidity, which predisposes them to pain management challenges. 1,2 The prevalence of pain in post-acute and long-term care is as high as 65%, and o.

Dec 7th, 2020 - In recent years, Percocet (oxycodone/paracetamol) has experienced a meteoric rise to prominence because of the presence of conspicuous references in pop culture and the ever-evolving hip-hop scene,1 so much so that even propafenone is being mislab.