ALLMedicine™ Cushing Syndrome Center

Jun 6th, 2021 - Pediatric endogenous Cushing syndrome (eCs) is mainly caused by pituitary corticotropin-producing adenomas, and most glucocorticoid-dependent effects progressively regress upon tumor removal. eCs reproduces long-term, high-dose glucocorticoid ther...

May 27th, 2021 - The clinical characteristics and complications of Cushing syndrome (CS) are well known and described in the literature. Nevertheless, rare, atypical presentations may go unnoticed. Osteonecrosis is a well-documented complication of glucocorticoid ...

May 26th, 2021 - The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients. Records of patients with ECS from 1986 to 2...

May 19th, 2021 - In-office subglottic intralesional steroid injections (SILSI) have gained popularity as an adjunct to operating room dilation in the treatment of subglottic stenosis. They are generally thought to have a low risk profile for development of systemi...

May 18th, 2021 - The dexamethasone suppression test (DST) is the recommended first-tier test for suspected Cushing syndrome (CS). Missed dexamethasone intake or insufficient dexamethasone serum exposure may yield false positive results. Quantification of serum dex...

Apr 28th, 2020 - This Phase 3 study involves two phases, an open-label (OL) phase and a randomized-withdrawal (RW) phase. Patients will dose-escalate in 100 mg increments to a target dose of 400 mg orally once daily during the open-label phase. Patients will remai...

Jan 6th, 2020 - Between 10 percent and 20 percent of patients with hypercortisolism (Cushing syndrome) have ectopic production of adrenocorticotropin hormone (ACTH) that causes cortisol excess. In approximately 50 percent of these patients, the source of ACTH can...

Jul 30th, 2019 - This retrospective chart review study seeks to collect data from pediatric patients treated with Korlym (mifepristone) to help provide clinicians with some insight on the potential role of mifepristone in the treatment of pediatric patients with C...

Apr 4th, 2019 - Objective: To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma. Methods: 234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrena...

Feb 21st, 2019 - Problem: Chronic steroid use causes a wide range of side effects, of which bone disease and adrenal suppression cause significant morbidity. Bone disease, which includes osteopenia, fractures, and osteonecrosis, is very common. In patients on chro...

Apr 14th, 2021 - Excess mortality among people with endogenous Cushing syndrome (CS) has declined in the past 20 years yet remains three times higher than in the general population, new research finds. Among more than 90,000 individuals with endogenous CS, the ove...

Sep 9th, 2020 - A physician is obligated to consider more than a diseased organ, more than even the whole man — he must view the man in his world. –Harvey Williams Cushing A well-known photo of Harvey Cushing, taken by a friend in Switzerland. Source: Wikimedia C...

Dec 11th, 2019 - The adrenal glands are a pair of triangular glands, each about 2 inches long and 1 inch wide, that sit on top of the kidneys. They are responsible for the release of hormones that regulate metabolism, immune system function, and the salt-water bal...

Dec 11th, 2019 - Patients with Cushing syndrome may have weight gain. They also frequently notice changes in their skin, including purple stretch marks, easy bruising, and other signs of skin thinning. They may have difficulty climbing stairs, getting out of a low...

Dec 11th, 2019 - The adrenal glands are a pair of triangular glands, each about 2 inches long and 1 inch wide, that sit on top of the kidneys. They are responsible for the release of hormones that regulate metabolism, immune system function, and the salt-water bal...