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About 2,630 results

ALLMedicine™ Primary Aldosteronism Center

Research & Reviews  972 results

Screening for Primary Aldosteronism in the Diabetic Population: a cohort study.
https://doi.org/10.1111/imj.15690
Internal Medicine Journal; Tan SJ, Libianto R et. al.

Jan 10th, 2022 - Primary aldosteronism (PA) is the most common endocrine cause of hypertension. It is associated with higher cardio-metabolic risk than essential hypertension. Hypertension is common in patients with type 2 diabetes who carry increased cardiovascul...

Mass spectrometry-based cortisol profiling during adrenal venous sampling reveals misdi...
https://doi.org/10.1111/cen.14666
Clinical Endocrinology; Ma Y, Chen H et. al.

Jan 1st, 2022 - Primary aldosteronism (PA) is a common form of secondary hypertension. Adrenal venous sampling (AVS) is the gold standard for subtyping PA. This study aimed to determine whether there is a difference between immunoassays and liquid chromatography-...

The saline infusion test for primary aldosteronism: implications of immunoassay inaccur...
https://doi.org/10.1210/clinem/dgab924
The Journal of Clinical Endocrinology and Metabolism; Eisenhofer G, Kurlbaum M et. al.

Dec 29th, 2021 - Diagnosis of primary aldosteronism (PA) for many patients depends on positive results for the saline infusion test (SIT). Plasma aldosterone is often measured by immunoassays, which can return inaccurate results. Establish whether differences in a...

A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domai...
https://doi.org/10.1113/JP282690
The Journal of Physiology; Shalomov B, Handklo-Jamal R et. al.

Dec 28th, 2021 - G protein-gated, inwardly rectifying potassium channels (GIRK) mediate inhibitory transmission in brain and heart, and are present in the adrenal cortex. GIRK4 (KCNJ5) subunits are abundant in the heart and adrenal cortex. Multiple mutations of KC...

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Guidelines  2 results

Guidelines for the diagnosis and treatment of primary aldosteronism--the Japan Endocrin...
https://doi.org/10.1507/endocrj.ej11-0133
Endocrine Journal; Nishikawa T, Omura M et. al.

Aug 11th, 2011 - The Japan Endocrine Society (JES) attempted to develop guidelines for the diagnosis and treatment of primary aldosteronism (PA). The Task Force Committee (TFC) was composed of a chair, selected by the JES, and additional experts. Systematic review...

Case detection, diagnosis, and treatment of patients with primary aldosteronism: an end...
https://doi.org/10.1210/jc.2008-0104
The Journal of Clinical Endocrinology and Metabolism; Funder JW, Carey RM et. al.

Jun 17th, 2008 - Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism. The Task Force comprised a chair, selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society, si...

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Clinicaltrials.gov  25 results

Calcium Channel Blockade in Primary Aldosteronism
https://clinicaltrials.gov/ct2/show/NCT04179019

Dec 9th, 2021 - BACKGROUND: Primary aldosteronism is a common cause of hypertension. The cause of primary aldosteronism can be a unilateral aldosterone-producing adenoma (APA) or bilateral idiopathic hyperaldosteronism (IHA) whereby there is diffuse production of...

A Study of CIN-107 in Adults With Primary Aldosteronism
https://clinicaltrials.gov/ct2/show/NCT04605549

Dec 2nd, 2021 - This is a Phase 2, randomized, placebo-controlled, multicenter, parallel-group, dose-ranging study in patients with PA to evaluate the efficacy and safety of up to 3 doses of CIN-107 as compared to placebo after 4 weeks of treatment.

Chongqing Primary Aldosteronism Study
https://clinicaltrials.gov/ct2/show/NCT03224312

Aug 26th, 2021 - This study will include the subjects of a series of studies on hypertension conducted by our team, including essential hypertension, PA subjects, and establish a large sample database and specimen bank through follow-up and omics analysis.

Neural Mechanism of Aldosterone-induced Insulin Resistance
https://clinicaltrials.gov/ct2/show/NCT02102243

Mar 22nd, 2021 - Patients with primary aldosteronism are known to have impaired insulin sensitivity, which is improved after removal of aldosterone-producing adenoma. In patients with essential hypertension, plasma aldosterone levels have been also shown to positi...

The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
https://clinicaltrials.gov/ct2/show/NCT01996449

Mar 19th, 2021 - Hypertensive patients are known to display exaggerated rise in blood pressure (BP) during exercise but the underlying mechanisms are poorly understood. Traditionally, muscle afferents were dichotomized as metaboreceptors, which are activated slowl...

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News  53 results

Alarmingly Low Rate of Primary Aldosteronism Detected, Treated
https://www.medpagetoday.com/endocrinology/steroids/91880

Mar 31st, 2021 - Primary aldosteronism (PA) has been underrecognized and probably undertreated in Canada, new research suggests. In a cohort study of 1.1 million adults with hypertension, a paltry 0.7% were screened for PA -- one of the most common causes of secon...

Few Adults at Risk for Primary Aldosteronism Get Screened
https://www.medscape.com/viewarticle/948177

Mar 29th, 2021 - NEW YORK (Reuters Health) - Only 3% of adults at high risk for primary aldosteronism (PA) are screened for the condition, according to a study presented at ENDO 2021, the Endocrine Society's annual meeting. "Primary aldosteronism causes persistent...

Will Scans Help Boost Detection of Resistant Hypertension?
https://www.medscape.com/viewarticle/948024

Mar 24th, 2021 - A noninvasive imaging method for identifying whether the source of a patient's primary aldosteronism is from unilateral or bilateral adrenal adenomas worked as well as the standard method, invasive adrenal vein sampling, in a head-to-head comparis...

Far Too Few With Treatment-Resistant Hypertension Get Hormone Test
https://www.medscape.com/viewarticle/943296

Dec 29th, 2020 - Millions of Americans with treatment-resistant hypertension are likely not being tested to determine whether their high blood pressure is driven by primary aldosteronism (PA), despite guidelines that call for such an approach, according to finding...

Adrenal Venous Sampling Not Always Required Before Unilateral Adenoma Treatment
https://www.medscape.com/viewarticle/940852

Nov 16th, 2020 - NEW YORK (Reuters Health) - In patients with primary aldosteronism and clearly visualized unilateral adenomas, confirmatory adrenal venous sampling (AVS) may not be required prior to surgery, researchers say. "It's important to realize that AVS is...

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