ALLMedicine™ Type 1 Diabetes Center

Jul 31st, 2021 - Glycocalyx lines the inner surface of the capillary endothelium. Capillaroscopy enables visualization of the sublingual capillaries and measurement of the Perfused Boundary Region (PBR) as an estimate of the glycocalyx. Novel software enables asse...

Jul 31st, 2021 - We aimed to test whether type 2 diabetes (T2D)-associated TCF7L2 genetic variants affect insulin sensitivity or secretion in autoantibody-positive relatives at risk for type 1 diabetes (T1D). We studied autoantibody-positive TrialNet Pathway to Pr...

Jul 30th, 2021 - To investigate the effectiveness of inpatient and outpatient interventions in attaining improved glycaemic control in children/adolescents with type 1 diabetes mellitus and persistently high/deteriorating HbA1c. A retrospective study at a tertiary...

Jul 30th, 2021 - The relationship between retinal vascular calibers (RVCs) and diabetic neuropathy is unclear. We investigated associations between RVCs and sensory nerve abnormality in adolescents with type 1 diabetes. In a prospective longitudinal study of 889 a...

Jul 30th, 2021 - To systematically review the literature concerning the psychosocial factors associated with repeat diabetic ketoacidosis for people living with type 1 diabetes. PsycInfo, Web of Science, CINAHL, PubMed and ASSIA were searched according to a regist...

Oct 14th, 2020 - Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and d...

Aug 23rd, 2020 - Our study aimed to review the impact of COVID-19 pandemia in children and adolescents with type 1 diabetes mellitus, to analyze the clinical characteristics of the infection and to propose clinical practice recommendations from the Italian Society...

Aug 11th, 2020 - Diabetic ketoacidosis (DKA) is a serious medical emergency once considered typical of type 1 diabetes (T1DM), but now reported to occur in type 2 and GDM patients as well. DKA can cause severe complications and even prove fatal. The aim of our stu...

Nov 7th, 2019 - Approximately 1 of every 300 children in the United States has type 1 diabetes mellitus (T1D), and these patients may require anesthetics for a variety of procedures. Perioperative coordination is complex, and attention to perioperative fasting, a...

Jun 28th, 2019 - Immune checkpoint inhibitors (ICIs) have become a promising treatment for advanced malignancies. However, these drugs can induce immune-related adverse events (irAEs) in several organs, including skin, gastrointestinal tract, liver, muscle, nerve,...

May 7th, 2020 - Eligible participants will be randomized to receive either oral insulin (7.5 mg of recombinant human insulin crystals) or placebo daily. All participants randomized into this study will be seen at a study site for a follow-up evaluation, three and...

May 7th, 2020 - Type 1 diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the pancreas called islet ce...

May 6th, 2020 - Type 1 diabetes mellitus (T1DM) is a T-cell mediated autoimmune disease in which insulin-producing beta cells are completely or near completely destroyed resulting in life-long dependence on exogenous insulin. CTLA4-Ig (Abatacept) inhibits a cruci...

May 5th, 2020 - Design of Study: The study is a multi-center, three-arm, randomized, double-masked, placebo-controlled clinical trial. Comparisons will be made among the three groups, which are: Mycophenolate mofetil active drug with Daclizumab (DZB) placebo IV M...

May 5th, 2020 - The investigators are doing this study to see the effect of insulin degludec in pregnant women with type 1 diabetes, and if it is safe to use. In this study the medicine insulin degludec is compared to another medicine called insulin detemir. Part...

Jul 19th, 2021 - NEW YORK (Reuters Health) - The tyrosine-kinase inhibitor imatinib used to treat chronic myeloid leukemia and other cancers may help preserve beta-cell function in people with recently diagnosed type-1 diabetes, according to findings from a phase-...

Jul 7th, 2021 - The US Food and Drug Administration (FDA) has declined to approve the anti-CD3 monoclonal antibody teplizumab (Tzield, Provention Bio) for the delay of type 1 diabetes in at-risk individuals, despite narrow endorsement in a 10-7 vote in favor of a...

Jul 6th, 2021 - Patients with type 1 diabetes who used insulin degludec as their basal insulin had fewer than half the number of nocturnal hypoglycemia events, compared with patients who used insulin glargine U100, in a head-to-head crossover study with 51 patien...

Jul 6th, 2021 - A novel investigational coformulation of prandial insulin and pramlintide improves blood glucose control and reduces body weight in people with type 1 diabetes, early research suggests. The injectable product combines a novel human prandial (pre-m...

Jul 1st, 2021 - A new draft consensus statement from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) addresses diagnosis and management of type 1 diabetes in adults.   The impetus for the document comes from t...