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About 184 results
Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2019
http://care.diabetesjournals.org/content/42/Supplement_1/S124

Dec 17th, 2018 - Chronic kidney disease (CKD) is diagnosed by the persistent presence of elevated urinary albumin excretion (albuminuria), low estimated glomerular filtration rate (eGFR), or other manifestations of kidney damage (1,2). In this section, the focus will be on CKD attributed to diabetes (diabetic kidney disease), which occurs in 20–40% of patients with diabetes (1,3–5). CKD typically develops after...

Relationship between glycated haemoglobin and microvascular complications: is there a n...
https://doi.org/10.1007/s00125-009-1360-5
Diabetologia Sabanayagam C, Liew G et. al.

Apr 23rd, 2009 - This study was designed to determine whether the relationship of glycated haemoglobin to diabetic microvascular complications shows any natural thresholds that could be useful in diagnosing diabetes. We examined a population-based sample of 3,190 Malay adults aged 40-80 years in Singapore. The microvascular outcomes of interest were: (1) any retinopathy, defined from fundus photographs; (2) mil...

No ethnic differences in the association of glycated hemoglobin with retinopathy: the n...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579340
Diabetes Care; Bower JK, Brancati FL et. al.

Oct 16th, 2012 - Current recommendations for the use of hemoglobin A(1c) (HbA(1c)) in diabetes screening and diagnosis aim to identify those at greatest risk for diabetic microvascular complications. However, there is current controversy regarding the clinical implications of ethnic differences in HbA(1c) values. The objective of this study was to determine whether the association between HbA(1c) and retinopath...

Association of Diabetic Microvascular Complications and Parameters of Obstructive Sleep...
https://doi.org/10.1089/dia.2015.0433
Diabetes Technology & Therapeutics; Zhang R, Zhang P et. al.

Mar 31st, 2016 - Obstructive sleep apnea (OSA) is prevalent in patients with type 2 diabetes, but the influence of OSA on diabetes complications is not clear. We aimed to investigate the association of OSA with chronic diabetes complications in Chinese patients with type 2 diabetes. In total, 880 hospitalized patients were enrolled in a multicenter, cross-sectional study that involved 12 hospitals from six citi...

Mechanism of diabetic neuropathy: Where are we now and where to go?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008011
Journal of Diabetes Investigation; Yagihashi S, Mizukami H et. al.

Jan 23rd, 2011 - Neuropathy is the most common complication of diabetes. As a consequence of longstanding hyperglycemia, a downstream metabolic cascade leads to peripheral nerve injury through an increased flux of the polyol pathway, enhanced advanced glycation end-products formation, excessive release of cytokines, activation of protein kinase C and exaggerated oxidative stress, as well as other confounding fa...

Osteoprosis in Type 2 Diabetic Patients- a Cohort Study
https://clinicaltrials.gov/ct2/show/NCT01846533

It is becoming apparent that both type 1 and type 2 diabetes mellitus are associated with an increased risk for osteoporosis-associated fractures. A meta-analysis by Vestergaard showed that patients with type 1 DM have decreased bone mineral density and increased fracture risk. This study noted a 6.9 relative risk of hip fracture, when the expected relative risk of fracture was only 1.4 based o...

Reduced progression of diabetic microvascular complications with islet cell transplanta...
https://doi.org/10.1097/TP.0b013e31820437f3
Transplantation Thompson DM, Meloche M et. al.

Jan 24th, 2011 - The effect of islet cell transplantation (ICT) on the progression of diabetic microvascular complications is not well understood. We have conducted a prospective, crossover, cohort study comparing ICT with intensive medical therapy on the progression of diabetic nephropathy, retinopathy, and neuropathy. The rate of decline in glomerular filtration rate is slower after ICT than on medical therap...

Association between circulating adipocytokine concentrations and microvascular complica...
https://doi.org/10.1016/j.jdiacomp.2015.11.004
Journal of Diabetes and Its Complications; Rodríguez AJ, Nunes Vdos S et. al.

Dec 19th, 2015 - The adipocytokines leptin and adiponectin have been variously associated with diabetic microvascular complications. No comprehensive clinical data exist examining the association between adipocytokines and the presence of these complications. This is a systematic review of cross-sectional studies comparing circulating adipocytokines in patients with type 2 diabetes mellitus (T2DM), with and wit...

Cellular and molecular mechanisms of vascular injury in diabetes--part I: pathways of v...
https://doi.org/10.1016/j.vph.2011.03.005
Vascular Pharmacology; Madonna R, De Caterina R

Apr 1st, 2011 - Diabetes-induced micro- and macrovascular complications are the major causes of morbidity and mortality in diabetic patients. While hyperglycemia is a key factor for the pathogenesis of diabetic microvascular complications, it is only one of the multiple factors capable of increasing the risk of macrovascular complications. Hyperglycemia induces vascular damage probably through a single common ...

The quality of life and economic burden of neuropathy in diabetic patients in Germany i...
https://doi.org/10.1016/j.diabres.2008.03.019
Diabetes Research and Clinical Practice; Happich M, John J et. al.

Jul 7th, 2008 - To describe the health-related quality of life (HRQOL), the resource utilization and annual costs associated with diabetic neuropathy (DN) in Germany. In this retrospective, observational study German internists, diabetologists and general practitioners provided information on 185 adult type 1 and type 2 diabetic patients with DN. Health-related quality of life (HRQOL) was assessed using generi...

Markers of Islet Endothelial Dysfunction Occur in Male B6.BKS(D)-Leprdb/J Mice and May ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413084
Endocrinology Hogan MF, Liu AW et. al.

Nov 21st, 2016 - Islet endothelial cells produce paracrine factors that support β-cell function and growth. Endothelial dysfunction underlies diabetic microvascular complications; thus, we hypothesized that in diabetes, islet endothelial cells become dysfunctional, which may contribute to β-cell secretory dysfunction. Islets/islet endothelial cells were isolated from diabetic B6.BKS(D)-Leprdb/J male (db/db) mic...

The Main Determinants of Serum Resistin Level in Type 2 Diabetic Patients are Renal Fun...
https://doi.org/10.1055/s-0043-121262
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association; Cebeci E, Cakan C et. al.

Feb 8th, 2018 - The association of increased resistin levels in chronic kidney disease with diabetic nephropathy has not yet been clarified. Our aim was to analyze the relationship between serum resistin levels and various diabetic microvascular complications in patients. A total of 83 patients were enrolled in this cross-sectional study. The subjects were divided into 3 groups: 27 patients with type 2 diabete...

Exploring mechanisms of diabetes-related macrovascular complications: role of methylgly...
https://doi.org/10.1254/jphs.11r12cp
Journal of Pharmacological Sciences; Mukohda M, Okada M et. al.

Feb 15th, 2012 - Methylglyoxal (MGO) is a metabolite of glucose. MGO binds to and modifies arginine, lysine, and cysteine residues in proteins, which leads to formation of a variety of advanced glycation end-products (AGEs) such as argpyrimidine and N(ε)-(carboxyethyl)lysine. The concentration of MGO significantly increases in plasma from diabetic patients. Increased plasma MGO level seems to be associated with...

Urinary 8-hydroxydeoxyguanosine levels in diabetic retinopathy patients.
https://doi.org/10.1177/112067210801800116
European Journal of Ophthalmology; Dong QY, Cui Y et. al.

Jan 18th, 2008 - Involvement of oxidative stress in the pathogenesis of diabetic microvascular complications has been proposed. Recently, 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. This study was undertaken to investigate whether the urinary levels of 8-OHdG are altered in patients with type 2 diabetes. The authors also attem...

Possible mechanisms of direct cardiovascular impact of GLP-1 agonists and DPP4 inhibitors.
https://doi.org/10.1007/s10741-018-9674-3
Heart Failure Reviews; Bistola V, Lambadiari V et. al.

Jan 31st, 2018 - Diabetes mellitus is a leading cause of cardiovascular morbidity and mortality worldwide. Traditional antidiabetic therapies targeting hyperglycemia reduce diabetic microvascular complications but have minor effects on macrovascular complications, including cardiovascular disease. Instead, cardiovascular complications are improved by antidiabetic medications (metformin) and other therapies (sta...

Incidence and risk of vaginal candidiasis associated with sodium-glucose cotransporter ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400166
Journal of Diabetes Investigation; Yokoyama H, Nagao A et. al.

Aug 23rd, 2018 - The prevalence and risk of vaginal candidiasis before and after initiating sodium-glucose cotransporter 2 (SGLT2) inhibitors, although some clinical trials have been carried out, have not been adequately shown in real-world practice. We investigated the incidence of vaginal Candida colonization and symptomatic vaginitis, and the clinical risk factors including diabetic microvascular complicatio...

Managing chronic kidney disease in diabetes patients with the latest chemical therapies.
https://doi.org/10.1080/17512433.2019.1552829
Expert Review of Clinical Pharmacology; Hu J, Du Y

Dec 4th, 2018 - Introduction: During the years, while treatment strategy for diabetes mellitus has improved, the incidence of diabetes worldwide increases continuously. Chronic kidney disease (CKD) is one of the major diabetic microvascular complications, and a primary cause leading to end-stage renal disease (ESRD). The progression to ESRD, affected by hyperglycemia and hypertension, is characterized by micro...

Use of RBC deformability index as an early marker of diabetic nephropathy.
https://doi.org/10.3233/CH-180434
Clinical Hemorheology and Microcirculation; Lee SB, Kim YS et. al.

Nov 19th, 2018 - Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN). 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Hemorheologic parameters, including erythrocyte ...

Association of prediabetes-associated single nucleotide polymorphisms with microalbumin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291388
PloS One; Choi JW, Moon S et. al.

Feb 5th, 2017 - Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is crucial in the pathogenesis of diabetic microvascular complications represented by microalbuminuria. Nonetheless, there is limited evidence regarding which single nucleotide polymorphisms (SNPs) are associated with prediabetes and whether genetic predisposition to prediabetes is related to microalbuminuria...

(Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319493
Journal of Diabetes Investigation; Kanda A, Ishida S

Mar 26th, 2018 - The renin-angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS), such as diabetic microvascular complications. Using ocular clinical samples and animal disease models, we elucidated molecular mechanisms in which tissue RAS excites the expression of vascular end...