ALLMedicine™ Glucose Intolerance Center

Mar 18th, 2023 - Thiazide diuretics are associated with glucose intolerance and new onset diabetes mellitus. Previous studies demonstrated that thiazides attenuate insulin secretion, but the molecular mechanisms remain elusive. We hypothesized that thiazides atten...

Mar 16th, 2023 - Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of type 1 diabetes from normal g...

Mar 12th, 2023 - Pregnancies post-bariatric surgery are increasingly common. It is important to understand how to manage prenatal care in this high-risk population to optimize perinatal outcomes. To determine among pregnancies post-bariatric surgery whether partic...

Mar 12th, 2023 - Gestational diabetes mellitus (GDM) is defined as glucose intolerance identified during pregnancy. The increased risk of pregnancy complications and the adverse health effects for the mother and baby associated with GDM require urgent and effectiv...

Mar 11th, 2023 - Cyclin-dependent kinase 1 (CDK1)/cyclin B1 phosphorylates many of the same substrates as mTORC1 (a key regulator of glucose metabolism), including the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Only mitotic CDK1 phosphorylates 4E-...

Feb 5th, 2008 - The treatment of infertile women with polycystic ovary syndrome (PCOS) is surrounded by many controversies. On the basis of the currently available evidence, a group of experts reached a consensus regarding the therapeutic challenges raised in the...

Mar 8th, 2023 - Cystic Fibrosis (CF) is a lethal inherited disease that primarily affects the lungs but also confers a high risk of diabetes, with up to 40-50% of adults experiencing Cystic Fibrosis-related diabetes (CFRD). CFRD is associated with an accelerated ...

Feb 27th, 2023 - Alzheimer's disease (AD) and type 2 diabetes (T2DM) pose linked, major threats to aging societies worldwide, but the relationship between these two diseases remains poorly understood. Hence, insulin resistance may account for the close epidemiolog...

Feb 24th, 2023 - The effect of smartphone applications for gestational diabetes management on risk of postpartum glucose intolerance, antenatal glycemic control, and other perinatal outcomes is unknown. This study is a randomized control trial in which patients di...

Feb 22nd, 2023 - The heart plays an endocrine role by secreting hormones called Natriuretic Peptides (NPs). NPs directly regulates blood pressure (BP) by causing dilation of blood vessels and removing sodium and water from the body. Apart from blood pressure regul...

Feb 21st, 2023 - Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced β-cell mass contributes to the insulin secretory defects that characterizes cystic fibrosis-related diabetes (CFR...

Dec 15th, 2022 - Among kids with type 2 diabetes (T2D), obesity was common but far from universal in a look at the condition worldwide. In fact, only 75% of pediatric cases were found to also have obesity, with a rate of 77% at the time of diagnosis, according to ...

Nov 7th, 2022 - The addition of CBM588, a live probiotic comprised primarily of Clostridium butyricum, to the combination of nivolumab (Opdivo) and ipilimumab (Yervoy) produced superior response rates and a progression-free survival (PFS) benefit vs nivolumab plu...

Aug 19th, 2022 - UPDATED August 23, 2022 // Editor's note: This story has been updated to include additional outside comments since its original publication. New research discounts the long-held notion that aspartame and other nonnutritive sweeteners (NNS) have no...

Nov 29th, 2021 - Gabriel N. Hortobagyi, MD, FACP: The PI3 gene is a critical gene that is centrally located in multiple metabolic processes. Mutations of this gene, the PIK3CA] occur in about 40% of patients with hormone receptor-positive breast cancer. Some of th...

Nov 19th, 2021 - Although steroids remain the frontline standard of care in chronic graft-vs-host disease (cGVHD), research into ways to augment their use and potentially replace them with more effective agents has become a significant area of interest, explained ...