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About 2,898 results

ALLMedicine™ Ovarian Insufficiency Center

Research & Reviews  995 results

Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leadin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10008699
International Journal of Biological Sciences; Demini L, Kervarrec C et. al.

Mar 17th, 2023 - EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-5' exoribonuclease activity. The enzyme processes and degrades different classes of RNAs. To delineate the role of EXOSC10 during oocyte growth, specific Exosc10 inactiv...

Live birth in woman with premature ovarian insufficiency and 46, XY karyotype after che...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012704
BMC Pregnancy and Childbirth; Zhang Y, Wang H et. al.

Mar 15th, 2023 - Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian function before the age of 40 years, characterized by elevated serum gonadotropin levels and decreased estrogen levels with menstrual disturbance. POI can be n...

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires
https://clinicaltrials.gov/ct2/show/NCT05567198

Mar 10th, 2023 - Study Description: SLE patients with life-threatening lupus manifestations are often treated with cyclophosphamide (CYC), which has known cytotoxic effects on ovarian reserve. Co-administration of Gonadotropinreleasing hormone agonist (GnRHa) is s...

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study
https://clinicaltrials.gov/ct2/show/NCT05548881

Mar 10th, 2023 - Study Description: This is a deep phenotype study of women who are determined to have 45,X mosaicism as a secondary genomic finding following cfDNA sequencing during pregnancy. Objectives: To define and describe a comprehensive phenotype of women ...

Gonadal function in pediatric Fanconi anemia patients treated with hematopoietic stem c...
https://doi.org/10.3324/haematol.2022.282094
Haematologica Koo J, Grom-Mansencal I et. al.

Mar 10th, 2023 - Gonadal dysfunction and reduced fertility are clinical manifestations well described in patients with Fanconi anemia (FA) and following hematopoietic stem cell transplantation (HSCT). It is difficult to differentiate gonadal dysfunction from the p...

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Guidelines  4 results

Clinical Summary: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women
https://allmedx.com/USPSTFPDF/hormone-therapy-clinical-summary.pdf

Dec 5th, 2017 - Clinical Summary: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women Population Postmenopausal women Postmenopausal women who have had a hysterectomy Recommendation Do not use combined estroge...

Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency.
https://doi.org/10.1097/AOG.0000000000002044
Obstetrics and Gynecology;

Apr 21st, 2017 - Primary ovarian insufficiency describes a spectrum of declining ovarian function and reduced fecundity due to a premature decrease in initial follicle number, an increase in follicle destruction, or poor follicular response to gonadotropins. The s...

ESHRE Guideline: management of women with premature ovarian insufficiency.
https://doi.org/10.1093/humrep/dew027
Human Reproduction (Oxford, England); , Webber L et. al.

Mar 25th, 2016 - What is the optimal management of women with premature ovarian insufficiency (POI) based on the best available evidence in the literature? The guideline development group (GDG) formulated 99 recommendations answering 31 key questions on the diagno...

ACMG Standards and Guidelines for fragile X testing: a revision to the disease-specific...
https://doi.org/10.1038/gim.2013.61
Genetics in Medicine : Official Journal of the American C... Monaghan KG, Lyon E et. al.

Jun 15th, 2013 - Molecular genetic testing of the FMR1 gene is commonly performed in clinical laboratories. Mutations in the FMR1 gene are associated with fragile X syndrome, fragile X tremor ataxia syndrome, and premature ovarian insufficiency. This document prov...

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Clinicaltrials.gov  76 results

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires
https://clinicaltrials.gov/ct2/show/NCT05567198

Mar 10th, 2023 - Study Description: SLE patients with life-threatening lupus manifestations are often treated with cyclophosphamide (CYC), which has known cytotoxic effects on ovarian reserve. Co-administration of Gonadotropinreleasing hormone agonist (GnRHa) is s...

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study
https://clinicaltrials.gov/ct2/show/NCT05548881

Mar 10th, 2023 - Study Description: This is a deep phenotype study of women who are determined to have 45,X mosaicism as a secondary genomic finding following cfDNA sequencing during pregnancy. Objectives: To define and describe a comprehensive phenotype of women ...

Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
https://clinicaltrials.gov/ct2/show/NCT05754593

Mar 8th, 2023 - Multiple sclerosis is an inflammatory disease of central nervous system, with a prevalence rate in France of 1 case/1000 subjects. The average age at diagnosis is 30 years old and it affects especially women, with a sex ratio of 3 women for 1 men....

Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response
https://clinicaltrials.gov/ct2/show/NCT04163640

Mar 6th, 2023 - Patients will be randomized to either receive the intra-ovarian PRP injection procedure or not. Regardless of randomization patients will be re-assessed at the same time points for ovarian reserve parameters. If antral follicles are detected at fo...

Efficacy, Safety, and Tolerability of Higher Doses Estrogen Therapy in Women With Premature Ovarian Insufficiency
https://clinicaltrials.gov/ct2/show/NCT05737329

Feb 28th, 2023 - The goal of this study is to assess the effects of higher doses versus standard hormone therapy on quality of life (QoL), symptoms due to estrogen deficiency, and bone health in women with premature ovarian insufficiency (POI). The efficacy of the...

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News  68 results

Top 10 Unproven Infertility Tests and Treatments
https://www.medscape.com/viewarticle/984553

Dec 1st, 2022 - In 2019, a New York Times opinion piece titled, “The Big IVF Add-On Racket – This is no way to treat patients desperate for a baby”[1] alleged exploitation of infertility patients based on a Fertility and Sterility article, “Do à la carte menus se...

USPSTF: No Hormone Therapy to Prevent Chronic Conditions After Menopause
https://www.medpagetoday.com/obgyn/hrt/101520

Nov 1st, 2022 - Steer clear of offering hormone therapy as primary prevention for chronic conditions, the U.S. Preventive Services Task Force (USPSTF) advised in an update to its 2017 recommendation. After reviewing new evidence, the Task Force felt with "moderat...

Early estrogen loss increases cardiovascular risk in women
https://www.mdedge.com/obgyn/article/259011/menopause/early-estrogen-loss-increases-cardiovascular-risk-women
Tara Haelle

Oct 26th, 2022 - The relationship between estrogen levels and heart health makes it particularly important for clinicians to be aware of those patients who might be at risk for cardiovascular disease despite not having other traditional risk factors, according to.

Early Estrogen Loss Increases Cardiovascular Risk in Women
https://www.medscape.com/viewarticle/983061

Oct 26th, 2022 - The relationship between estrogen levels and heart health makes it particularly important for clinicians to be aware of those patients who might be at risk for cardiovascular disease despite not having other traditional risk factors, according to ...

Age at Chemotherapy Linked to Fertility Problems Later
https://www.medscape.com/viewarticle/982546

Oct 17th, 2022 - The study covered in this summary was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaway Among female pediatric patients with cancer, chemotherapy after the age of 12 was associated with premature ovaria...

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Patient Education  16 results see all →