ALLMedicine™ Insulin Center

Sep 15th, 2021 - Associations of arterial stiffness with glucose, insulin, and proinsulin dynamics during the oral glucose tolerance test (OGTT) remain under debate. The aim of this study was to investigate whether plasma glucose (PG), insulin, and proinsulin (Pro...

Sep 15th, 2021 - The pleiotropic effects of glucagon-like peptide-1 receptor (GLP-1R) agonists on the heart have been recognized in obese or diabetic patients. However, little is known regarding the molecular mechanisms of these agonists in cardioprotective action...

Sep 15th, 2021 - To examine the mediating role of adiposity on the associations of diet quality with longitudinal changes in insulin sensitivity and beta-cell function. Adults at-risk for type 2 diabetes (T2D) in the PROMISE cohort had 4 assessments over 9 years (...

Sep 15th, 2021 - To evaluate the change in circulating serum irisin and interleukin-6 (IL-6), in patients with type 2 diabetes mellitus (T2DM) after 6 and 12 months of GLP-1 treatment. Eighty-five patients with T2DM inadequately controlled with insulin or other hy...

Sep 15th, 2021 - In this study, it was aimed to investigate the relationship between expression levels of micrornas, endoplasmic reticulum (ER) stress, apoptosis and oxidative stress markers in hepatic ischemia reperfusion (IR) injury. Sixteen rats were randomized...

Oct 14th, 2020 - Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and d...

Sep 17th, 2020 - The International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guideline 2018 for management of diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state provide comprehensive guidance for management of DKA ...

Sep 1st, 2020 - The American Diabetes Association (ADA) updates the Standards of Medical Care in Diabetes annually to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and managem...

Aug 29th, 2020 - Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment, transforming outcomes in melanoma and showing benefit in a range of malignancies. Immune-mediated toxicities, stemming from increased activity within the T ...

Jan 25th, 2020 - : High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural produ...

Sep 10th, 2021 - The sirtuin family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase enzymes are important regulators of the aging process (1-5) and mediate many of the beneficial effects of caloric restriction (6-9). The upregulation of the sirtu...

Sep 9th, 2021 - Researchers are looking for a better way to help Chinese people who have diabetes to monitor their blood sugar situation. There are 2 types of diabetes. In people with type 1 diabetes, the body's immune system attacks and destroys cells in the pan...

Sep 5th, 2021 - Postprandial hypoglycemia is a debilitating medical complication after bariatric surgery for which no approved pharmacological treatment exists. The prevalence of hypoglycemia in bariatric patients ranges from 0.5 % severe episodes up to 56 % and ...

Sep 5th, 2021 - The anthropometry data included body weight and body fat. The sarcopenia index included appendicular skeletal muscle mass index, calf circumferences, hand grip and gait speed. Moreover, blood biochemical index (liver function as ALT, kidney functi...

Sep 2nd, 2021 - Alpelisib is a p110α specific PI3K inhibitor that has shown significant clinical benefit in patients with HR+/HER2 negative mBC harboring activating PIK3CA mutations. The SOLAR-1 study randomized patients with MBC progressing after aromatase inhib...

Jul 20th, 2021 - This transcript has been edited for clarity. The story of cardiovascular outcomes in diabetes is a fascinating one. There were new developments in the regulatory landscape that really drove the past 10 years of history. If you go way back to the f...

Jul 19th, 2021 - NEW YORK (Reuters Health) - The tyrosine-kinase inhibitor imatinib used to treat chronic myeloid leukemia and other cancers may help preserve beta-cell function in people with recently diagnosed type-1 diabetes, according to findings from a phase-...

Jul 15th, 2021 - This transcript has been edited for clarity. I'm here to talk about tirzepatide, a dual GIP/GLP-1 receptor agonists that's under investigation for the management of type 2 diabetes, obesity, and fatty liver disease. We're all very used to GLP-1 re...

Jul 14th, 2021 - As use of fecal microbial transplantation evolves, new research shows that a noninvasive approach ― with an oral capsule formulation ― combined with fiber supplementation significantly improved insulin sensitivity among those with severe obesity a...

Jul 12th, 2021 - Abiraterone acetate (Zytiga) plus prednisone should be considered as the first treatment choice for patients with newly diagnosed metastatic castration-resistant prostate cancer (mCRPC) if fatigue is a concern. However, the regimen has been associ...