About 165,470 results

ALLMedicine™ Insulin Center

Research & Reviews  57,196 results

PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and...
Hepatology (Baltimore, Md.); Shearer AM, Wang Y et. al.

May 24th, 2022 - Insulin resistance and poor glycemic control are key drivers of the development of non-alcoholic fatty liver disease (NAFLD) and have recently been shown to be associated with fibrosis progression in nonalcoholic steatohepatitis (NASH). However, t...

The missing heritability in type 1 diabetes mellitus.
Diabetes, Obesity & Metabolism; Pang H, Lin J et. al.

May 24th, 2022 - Type 1 diabetes mellitus (T1DM) is a complex autoimmune disease characterized by an absolute deficiency of insulin. It affects more than 20 million people worldwide and imposes an enormous financial burden on patients. The underlying pathogenic me...

Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice.
https://doi.org/10.1007/s11357-022-00589-1 10.1016/j.neuron.2017.02.004 10.1038/nrneurol.2013.269 10.1016/j.arr.2014.11.001 10.1016/S0092-8674(01)00306-3 10.1038/nrendo.2015.173 10.1016/j.nut.2004.06.030 10.1096/fj.202001281RR 10.1038/nrn2092 10.1038/nrn2474 10.1016/j.arr.2004.08.001 10.1016/j.mcn.2011.07.008 10.18632/aging.101739 10.1016/j.exger.2014.10.002 10.1016/S0304-3940(00)01170-8 10.1016/j.neurobiolaging.2007.12.006 10.1016/j.ghir.2019.02.003 10.1038/mp.2011.128 10.1002/cyto.a.21079 10.1369/jhc.2010.956920 10.1523/JNEUROSCI.1002-07.2007 10.1093/sleep/16.1.40 10.1016/j.neurobiolaging.2010.05.010 10.1038/tp.2013.102 10.1210/mend-5-8-1158 10.1023/A:1018581407804 10.1016/S0896-6273(02)01132-7 10.1523/JNEUROSCI.21-15-05678.2001 10.1016/j.neuron.2010.08.007 10.3389/fnins.2013.00216 10.1016/j.tips.2011.03.007 10.1016/j.ejmech.2021.113620 10.1091/mbc.e07-08-0811 10.18632/aging.100552 10.1172/JCI118499 10.1016/0306-4522(95)00524-2 10.1016/j.neurobiolaging.2008.04.002 10.1172/JCI59903 10.1111/acel.12932 10.1016/j.neuroscience.2005.10.029 10.3389/fnagi.2021.682388 10.1371/journal.pbio.0060254 10.1038/366461a0 10.1038/s41467-018-04805-5 10.1111/acel.12213 10.1007/s11357-017-9971-0 10.1111/acel.12000 10.1371/journal.pone.0026891 10.1186/1471-2318-9-19 10.1210/jc.2002-021810 10.1016/j.mad.2009.10.002 10.1073/pnas.95.26.15603 10.1210/jcem.84.2.5455 10.1016/j.archger.2009.09.006 10.1016/j.ghir.2005.09.001 10.1271/bbb.60472 10.1073/pnas.1002696107 10.1016/j.bbrc.2012.05.145 10.1111/acel.12610 10.1016/j.cmet.2016.05.014 10.1371/journal.pbio.1000372 10.1016/j.neurobiolaging.2016.02.008 10.1016/j.ghir.2006.11.001 10.1016/S0306-4522(01)00378-5 10.1159/000084872 10.1016/j.brainres.2015.11.010 10.1016/j.celrep.2017.01.053 10.1007/s40266-018-0569-8
GeroScience Zegarra-Valdivia JA, Fernandes J et. al.

May 24th, 2022 - Sleep disturbances are common during aging. Compared to young animals, old mice show altered sleep structure, with changes in both slow and fast electrocorticographic (ECoG) activity and fewer transitions between sleep and wake stages. Insulin-lik...

Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Pre...
Journal of Alzheimer's Disease : JAD; Wittfeld K, Raman MR et. al.

May 24th, 2022 - Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer's disease pathogenesis, and further evidence suggests inflammation can be a moderator of this association. However, most research to date has been conducted on older a...

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Guidelines  37 results

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Pro...
Orphanet Journal of Rare Diseases; Mosbah H, Donadille B et. al.

Apr 21st, 2022 - Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole N...

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2
Cell Metabolism; Reiterer M, .

Sep 15th, 2021 - Individuals infected with SARS-CoV-2 who also display hyperglycemia suffer from longer hospital stays, higher risk of developing acute respiratory distress syndrome (ARDS), and increased mortality. Nevertheless, the pathophysiological mechanism of...

Glucose management for exercise using continuous glucose monitoring (CGM) and intermitt...
Pediatric Diabetes; Moser O, Riddell MC et. al.

Oct 14th, 2020 - Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and d...

ISPAD Clinical Practice Consensus Guideline: Diabetic ketoacidosis in the time of COVID...
Pediatric Diabetes; Priyambada L, Wolfsdorf JI et. al.

Sep 17th, 2020 - The International Society for Pediatric and Adolescent Diabetes Clinical Practice Consensus Guideline 2018 for management of diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state provide comprehensive guidance for management of DKA ...

Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020...
Annals of Internal Medicine; Doyle-Delgado K, Chamberlain JJ et. al.

Sep 1st, 2020 - The American Diabetes Association (ADA) updates the Standards of Medical Care in Diabetes annually to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and managem...

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Drugs  345 results see all →

Clinicaltrials.gov  3,561 results

Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older

May 20th, 2022 - Study Description: We hypothesize that supplementation with a ketone ester drink [Ketone Ester (KE)] compared to placebo, in cognitively intact adults >= 55 years old with Metabolic Syndrome (MetS), will (i) increase peripheral and brain ketone le...

Prospective Studies of the Natural History of Diabetes Mellitus and Its Complications in the Gila River Indian Community

May 20th, 2022 - This project is a continuation of an extensive longitudinal population-based epidemiological investigation of the etiology and determinants of type 2 diabetes (and its complications) and formerly arthritis. The original baseline observations were ...

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

May 20th, 2022 - Background: Consumption of non-nutritive sweeteners (NNS) has dramatically increased worldwide and is more prevalent in women than men. Similarly, obesity rates have continued to rise, most notably in minorities. Since NNS consumption has been lin...

Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima Indians

May 20th, 2022 - Insulin resistance and a defect in early insulin secretion are risk factors for the development of type 2 diabetes mellitus. A recent longitudinal analysis which tracked the development of diabetes demonstrated that both insulin action and early i...

Protein and Carbohydrate Loading in Elderly With Hip Fractures

May 20th, 2022 - INTRODUCTION AND BACKGROUND Pre-operative carbohydrate loading is one of the many components of enhanced recovery after surgery (ERAS) protocol. It has been identified as one of the independent predictors among ERAS components to improve peri-oper...

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News  5,010 results

Obesity and lung disease: Much more than BMI
Christine Kilgore

May 20th, 2022 - The diverse effects of obesity on lung health and disease are increasingly being teased apart, with researchers honing in on the impact of metabolic dysfunction, circulating inflammatory factors produced by adipose tissue, lipid handling, and othe.

Fast Five Quiz: Type 2 Diabetes Incretin-Based Therapy

May 16th, 2022 - Disease burden in patients with type 2 diabetes is largely driven by the associated long-term complications, making glycemic control an invaluable treatment goal. In 2005, the first incretin-based agent was introduced into the type 2 diabetes trea...

First Fatty Liver Guidelines for Endocrinology, Primary Care

May 13th, 2022 - New clinical practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease (NAFLD) are the first to be targeted specifically to primary care and endocrinology clinical settings. They include 34 evidence-based clinical pr...

Arkansas Sues Drugmakers, Pharmacy Benefit Managers Over Insulin Costs

May 12th, 2022 - (Reuters) - Arkansas's attorney general on Wednesday accused drugmakers and pharmacy benefit managers of colluding to drive up the price of insulin drugs, the latest in a series of lawsuits to take aim at skyrocketing insulin costs. The lawsuit, f...

Fast Five Quiz: Type 2 Diabetes and Pregnancy

May 11th, 2022 - The prevalence of both type 2 diabetes and gestational diabetes is increasing dramatically in conjunction with the worldwide obesity epidemic. Hyperglycemia, owing to pregnancy-induced and preexisting insulin resistance, is associated with signifi...

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Patient Education  39 results see all →