ALLMedicine™ Insulin Center

Mar 18th, 2023 - Background It is unclear whether hybrid closed-loop therapy (HCL) attenuates the metabolic impact of missed or suboptimal meal insulin bolus compared with sensor-augmented pump therapy (SAP) in children with type 1 diabetes in free-living conditio...

Mar 18th, 2023 - Outcomes following pancreas transplantation are suboptimal and better donor selection is required to improve this. Vasoactive drugs (VaD) are commonly used to correct the abnormal haemodynamics of organ donors in intensive care units. VaDs can dif...

Mar 18th, 2023 - Abdominal obesity has been suggested as a risk factor for glioma; however, it is unclear whether this association applies to people with diabetes. This study examined the association between abdominal obesity and the risk of developing gliomas in ...

Mar 18th, 2023 - The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell transcriptomic approach. One subset of beta cells marked by high CD63 ...

Mar 18th, 2023 - Intra-hepatic islet transplantation for type-1 diabetes is limited by the need for multiple infusions and poor islet viability post-transplantation. The development of alternative transplantation sites is necessary to improve islet survival, and f...

Dec 9th, 2022 - Hypoglycemia in people with diabetes is common, especially in those taking medications such as insulin and sulfonylureas (SU) that place them at higher risk. Hypoglycemia is associated with distress in those with diabetes and their families, medic...

Nov 22nd, 2022 - To provide clear and concise guidelines for the diagnosis and management of preterm prelabour rupture of membranes (PPROM) TARGET POPULATION: All patients with PPROM <37 weeks gestation BENEFITS, HARMS, AND COSTS: This guideline aims to provide th...

Aug 14th, 2022 - The objective of this clinical practice guideline is to provide updated and new evidence-based recommendations for the comprehensive care of persons with diabetes mellitus to clinicians, diabetes-care teams, other health care professionals and sta...

Jul 5th, 2022 - The prevalence of obesity and diabetes is an increasing global problem, especially in developed countries, and is referred to as the twin epidemics. As such, advanced treatment approaches are needed. Tirzepatide, known as a ‘twincretin’, is a ‘fir...

Jul 3rd, 2022 - To the Editor We read with great interest the article “Fulminant type 1 diabetes (T1DM) after Covid-19 vaccination” by Tang et al. in this journal [1]. The authors examined islet autoantibodies, HLA alleles, and the capacity for insulin secreti...

Mar 14th, 2023 - Study design: This is a triple-blind, parallel, placebo-controlled, randomized clinical trial. Sample size: The sample size was calculated to observe a difference of 15% in insulin sensitivity based on two outcomes: glucose rate of appearance (Ra)...

Mar 10th, 2023 - Cognitive impairment is common in and devastating to people with MS. MS is a common, chronic, central nervous system (CNS) disease characterized by inflammation, demyelination, and neurodegeneration. One of the most devastating symptoms of this di...

Mar 10th, 2023 - Cardiovascular disease (CVD) afflicts nearly one-third of the adult population with all races and ethnicities represented in CVD prevalence. Unfortunately, a disparity exists such that the black population (BL) is disproportionately affected compa...

Mar 10th, 2023 - Elderly patients have an increased susceptibility to burns and a substantial mortality that has not significantly changed over the last three decades. Elderly burn patients not only have an augmented response to burn but also express a prolonged h...

Mar 10th, 2023 - Healthy volunteers were recruited from the Old Order Amish population in Lancaster County, Pennsylvania. After providing informed consent, research participants were screened for eligibility. The clinical trial was designed as a randomized crossov...

Mar 20th, 2023 - Note that some links may require subscriptions. A Washington Post analysis suggests long COVID symptoms have become less common since the Omicron variant. Military pilots have higher rates of cancer, as do aircraft ground crews, a Pentagon study f...

Mar 17th, 2023 - Note that some links may require subscriptions. A new analysis of genetic samples from China appears to link the origin of COVID-19 to raccoon dogs. (The Atlantic) What's a raccoon dog, anyhow? (Wikipedia) After a 2-year pandemic spike, maternal d...

Mar 15th, 2023 - Very young children with type 1 diabetes saw glycemic benefits when using a hybrid closed-loop system, the randomized PEDAP trial showed. Among 102 children ages 2 to 5 years, the mean percentage of time that the glucose level was within the targe...

Mar 15th, 2023 - Note that some links may require subscriptions. The mortality rate of children and teens rose sharply in 2020 and 2021, driven by factors unrelated to COVID-19 itself. (JAMA) Drugmaker Novo Nordisk said it will slash its insulin prices, following ...

Mar 14th, 2023 - The Biden administration proposed the first-ever limit on PFAS in drinking water. If finalized, the nationwide limit on the endocrine-disrupting chemicals PFOA and PFOS would be capped at 4 parts per trillion. (The Hill) Over the past 20 years, pr...