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ALLMedicine Hyperglucagonemia Center

Research & Reviews  161 results

Effect of short-term intensive insulin therapy on α-cell function in patients with newl...
https://doi.org/10.1097/MD.0000000000019685
Medicine Zheng HL, Xing Y et. al.

Apr 3rd, 2020 - The effect of intensive insulin therapy on hyperglucagonemia in newly diagnosed type 2 diabetes (T2DM), and its associations with β-cell function, has not been elucidated. This study assessed the effect of 12 weeks of intensive insulin therapy on ...

Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic ...
https://doi.org/10.2337/db19-0715
Diabetes Suppli MP, Bagger JI et. al.

Jan 24th, 2020 - Glucagon secretion is regulated by circulating glucose, but it has turned out that amino acids also play an important role and that hepatic amino acid metabolism and glucagon are linked in a mutual feedback cycle, the liver-α-cell axis. On the bas...

A Primary Role for α-Cells as Amino Acid Sensors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085241
Diabetes Dean ED

Oct 27th, 2019 - Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in di...

Obesity dysregulates fasting-induced changes in glucagon secretion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994388
The Journal of Endocrinology; Stern JH, Smith GI et. al.

Aug 27th, 2019 - Hyperglucagonemia, a hallmark in obesity and insulin resistance promotes hepatic glucose output, exacerbating hyperglycemia and thus predisposing to the development type 2 diabetes. As such, glucagon signaling is a key target for new therapeutics ...

Effects of Metreleptin in Type 1 Diabetes Mellitus
https://clinicaltrials.gov/ct2/show/NCT01268644

Aug 27th, 2019 - The adipocyte hormone, leptin, has been shown to restore the health and glucoregulation of near-death, insulin deficient diabetic rodents. This makes leptin the only hormone, since the discovery of insulin in 1922, with this capability. Leptin nor...

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Clinicaltrials.gov  163 results

Effect of short-term intensive insulin therapy on α-cell function in patients with newl...
https://doi.org/10.1097/MD.0000000000019685
Medicine Zheng HL, Xing Y et. al.

Apr 3rd, 2020 - The effect of intensive insulin therapy on hyperglucagonemia in newly diagnosed type 2 diabetes (T2DM), and its associations with β-cell function, has not been elucidated. This study assessed the effect of 12 weeks of intensive insulin therapy on ...

Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic ...
https://doi.org/10.2337/db19-0715
Diabetes Suppli MP, Bagger JI et. al.

Jan 24th, 2020 - Glucagon secretion is regulated by circulating glucose, but it has turned out that amino acids also play an important role and that hepatic amino acid metabolism and glucagon are linked in a mutual feedback cycle, the liver-α-cell axis. On the bas...

A Primary Role for α-Cells as Amino Acid Sensors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085241
Diabetes Dean ED

Oct 27th, 2019 - Glucagon and its partner insulin are dually linked in both their secretion from islet cells and their action in the liver. Glucagon signaling increases hepatic glucose output, and hyperglucagonemia is partly responsible for the hyperglycemia in di...

Obesity dysregulates fasting-induced changes in glucagon secretion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994388
The Journal of Endocrinology; Stern JH, Smith GI et. al.

Aug 27th, 2019 - Hyperglucagonemia, a hallmark in obesity and insulin resistance promotes hepatic glucose output, exacerbating hyperglycemia and thus predisposing to the development type 2 diabetes. As such, glucagon signaling is a key target for new therapeutics ...

Effects of Metreleptin in Type 1 Diabetes Mellitus
https://clinicaltrials.gov/ct2/show/NCT01268644

Aug 27th, 2019 - The adipocyte hormone, leptin, has been shown to restore the health and glucoregulation of near-death, insulin deficient diabetic rodents. This makes leptin the only hormone, since the discovery of insulin in 1922, with this capability. Leptin nor...

see more →

News  1 results

Multiple Metabolic Abnormalities Seen in Lupus
https://www.medpagetoday.com/rheumatology/lupus/64321

Apr 4th, 2017 - Action Points Note that this meal-tolerance study suggested that patients with mild or inactive lupus had greater indices of insulin resistance than healthy controls. Be aware that the small sample size precluded final adjustment for potential con...

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