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ALLMedicine™ Ochronosis Center

Research & Reviews  215 results

Localized argyria with pseudo-ochronosis.
https://doi.org/10.1111/cup.13688
Journal of Cutaneous Pathology REFERENCES; Lee J, Korgavkar K et. al.

Nov 9th, 2020 - Localized argyria with pseudo-ochronosis.|2020|Lee J,Korgavkar K,DiMarco C,Robinson-Bostom L,|

Hydroquinone: myths and reality.
https://doi.org/10.1111/ced.14480
Clinical and Experimental Dermatology References; Searle T, Al-Niaimi F et. al.

Nov 7th, 2020 - Hydroquinone has pharmacological uses in disorders of pigmentation because of its ability to competitively inhibit the enzyme tyrosinase. Our contemporary review presents the strongest evidence supporting the use of hydroquinone with the most effe...

Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with C...
https://doi.org/10.1007/s00223-020-00764-6
Calcified Tissue International; Hughes JH, Keenan CM et. al.

Oct 15th, 2020 - Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe...

Cervical Myelopathy Due to Ochronosis: An Intraoperative Suspicion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491942
The American Journal of Case Reports; Alisi MS, Al-Saber MG et. al.

Sep 10th, 2020 - BACKGROUND Alkaptonuria (AKU) is a rare metabolic disease caused by a deficiency in homogentisic acid oxidase, which leads to the accumulation of homogentisic acid dark pigments in tissues such as bones, ligaments, and tendons. Long-term duration ...

Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach.
https://doi.org/10.1097/DAD.0000000000001571
The American Journal of Dermatopathology; Ho JD, Vashi N et. al.

Jul 23rd, 2020 - Exogenous ochronosis (EO) is a deposition disease associated with application of hydroquinone-containing preparations. Characteristic ochronotic bodies (OBs) arise from endogenous connective tissues, most often reported as collagen. We highlight a...

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Clinicaltrials.gov  219 results

Localized argyria with pseudo-ochronosis.
https://doi.org/10.1111/cup.13688
Journal of Cutaneous Pathology REFERENCES; Lee J, Korgavkar K et. al.

Nov 9th, 2020 - Localized argyria with pseudo-ochronosis.|2020|Lee J,Korgavkar K,DiMarco C,Robinson-Bostom L,|

Hydroquinone: myths and reality.
https://doi.org/10.1111/ced.14480
Clinical and Experimental Dermatology References; Searle T, Al-Niaimi F et. al.

Nov 7th, 2020 - Hydroquinone has pharmacological uses in disorders of pigmentation because of its ability to competitively inhibit the enzyme tyrosinase. Our contemporary review presents the strongest evidence supporting the use of hydroquinone with the most effe...

Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with C...
https://doi.org/10.1007/s00223-020-00764-6
Calcified Tissue International; Hughes JH, Keenan CM et. al.

Oct 15th, 2020 - Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe...

Cervical Myelopathy Due to Ochronosis: An Intraoperative Suspicion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491942
The American Journal of Case Reports; Alisi MS, Al-Saber MG et. al.

Sep 10th, 2020 - BACKGROUND Alkaptonuria (AKU) is a rare metabolic disease caused by a deficiency in homogentisic acid oxidase, which leads to the accumulation of homogentisic acid dark pigments in tissues such as bones, ligaments, and tendons. Long-term duration ...

Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach.
https://doi.org/10.1097/DAD.0000000000001571
The American Journal of Dermatopathology; Ho JD, Vashi N et. al.

Jul 23rd, 2020 - Exogenous ochronosis (EO) is a deposition disease associated with application of hydroquinone-containing preparations. Characteristic ochronotic bodies (OBs) arise from endogenous connective tissues, most often reported as collagen. We highlight a...

see more →

News  5 results

Incidentally Discovered Ochronosis Explaining Decades of Chronic Pain
https://www.mdedge.com/fedprac/article/215093/pain/incidentally-discovered-ochronosis-explaining-decades-chronic-pain/page/0/2?channel=285

Jan 7th, 2020 - Manipulating the metabolic pathway of phenylalanine with medication is a second option. An example of this is nitisinone, a US Food and Drug Administration-approved medication for treatment of tyrosinemia.

Localized Argyria With Pseudo-ochronosis
https://www.mdedge.com/dermatology/article/96357/dermatopathology/localized-argyria-pseudo-ochronosis
Kyle M. Devins, BS, Herman S. Mogavero Jr, MD et. al.

Jan 9th, 2015 - Localized cutaneous argyria often presents as asymptomatic black or blue-gray pigmented macules in areas of the skin exposed to silver-containing compounds. 1 Silver may enter the skin by traumatic implantation or absorption via eccrine sweat gland.

Primary Multiple Miliary Osteoma Cutis and Exogenous Ochronosis
https://www.mdedge.com/dermatology/article/66664/primary-multiple-miliary-osteoma-cutis-and-exogenous-ochronosis
Bowman PH, Lesher Jl Jr

Multiple miliary osteoma cutis (MMOC), a rare disorder characterized by the appearance of numerous bony nodules on the face, was initially classified as a consequence of severe, long-standing acne vulgaris. However, several cases have now been des.

On the Ocular Findings in Ochronosis
https://www.medscape.com/viewarticle/820497

Abstract Background Ochronosis/Alkaptonuria is a tyrosine metabolism disorder where accumulation of homogentisic acid, in eye, skin, cartilage and several other connective tissues leads to a black pigmentation of the affected tissues. It is autoso...

On the Ocular Findings in Ochronosis
https://www.medscape.com/viewarticle/820497_4

Results Our literature search revealed 74 articles. Within them we found 36 relevant case reports including 40 patients published between 1942 and 2012. Excluded articles and respective reasons are given in Table 1. The mean age of our patients wa...

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