ALLMedicine™ Ochronosis Center
Research & Reviews 85 results
Journal of Inherited Metabolic Disease; Kumps C, Stanovici J et. al.
Jul 16th, 2021 - Black cartilage: Incidentally discovered articular ochronosis during arthroplasty.|2021|Kumps C,Stanovici J,Chaibi E,Campos-Xavier B,Pavlidou DC,|
International Journal of Dermatology; Krueger L, Saizan A et. al.
Jul 9th, 2021 - Dermoscopy has traditionally been used for the diagnosis of neoplasms and more recently in the evaluation of inflammatory conditions. Recent observational studies have suggested a role for dermoscopy in identifying and differentiating acquired pig...
Journal of Cardiac Surgery; Velez AK, Gaughan NA et. al.
Jun 14th, 2021 - Cardiac ochronosis is a rare disease, estimated to affect 1 in 250,000 persons. While there is extensive evidence of the musculoskeletal alterations of the disease, cardiac involvement has not been widely studied and most information we currently ...
Jun 10th, 2021 - Alkaptonuria is caused by deficiency of homogentisate 1,2-dioxygenase, an enzyme that converts homogentisic acid (HGA) to maleylacetoacetic acid in the tyrosine degradation pathway. The three major features of alkaptonuria are dark urine or urine ...
Current Allergy and Asthma Reports; Chu P, Cuellar MC et. al.
Mar 6th, 2021 - Ochronosis and alkaptonuria are manifestations of the same condition-a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (HGA). In oc...
Clinicaltrials.gov 2 results
Feb 25th, 2020 - Alkaptonuria is a rare autosomal recessive disorder in which homogentisic acid accumulates and destroys connective tissue and bone, creating a condition called ochronosis. Symptoms generally begin in the third or fourth decade and progress to inca...
Jan 19th, 2011 - Alkaptonuria is a rare metabolic disease in which homogentisic acid (HGA), an intermediary metabolite in tyrosine catabolism, accumulates due to deficiency of the enzyme homogentisic acid oxidase. Patients with alkaptonuria exhibit homogentisic ac...
News 6 results
Jan 7th, 2020 - Manipulating the metabolic pathway of phenylalanine with medication is a second option. An example of this is nitisinone, a US Food and Drug Administration-approved medication for treatment of tyrosinemia.
Kyle M. Devins, BS, Herman S. Mogavero Jr, MD et. al.
Jan 9th, 2015 - Localized cutaneous argyria often presents as asymptomatic black or blue-gray pigmented macules in areas of the skin exposed to silver-containing compounds. 1 Silver may enter the skin by traumatic implantation or absorption via eccrine sweat gland.
Apr 9th, 2012 - Dyspigmentation from acne or inflammatory skin disease is a frustrating problem for both patients and dermatologists. Postinflammatory hyperpigmentation can last up to 2 years without proper treatment.
Results Our literature search revealed 74 articles. Within them we found 36 relevant case reports including 40 patients published between 1942 and 2012. Excluded articles and respective reasons are given in Table 1. The mean age of our patients wa...
Abstract Background Ochronosis/Alkaptonuria is a tyrosine metabolism disorder where accumulation of homogentisic acid, in eye, skin, cartilage and several other connective tissues leads to a black pigmentation of the affected tissues. It is autoso...