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About 233 results

ALLMedicine™ Ochronosis Center

Research & Reviews  85 results

Black cartilage: Incidentally discovered articular ochronosis during arthroplasty.
https://doi.org/10.1002/jimd.12417
Journal of Inherited Metabolic Disease; Kumps C, Stanovici J et. al.

Jul 16th, 2021 - Black cartilage: Incidentally discovered articular ochronosis during arthroplasty.|2021|Kumps C,Stanovici J,Chaibi E,Campos-Xavier B,Pavlidou DC,|

Dermoscopy of acquired pigmentary disorders: a comprehensive review.
https://doi.org/10.1111/ijd.15741
International Journal of Dermatology; Krueger L, Saizan A et. al.

Jul 9th, 2021 - Dermoscopy has traditionally been used for the diagnosis of neoplasms and more recently in the evaluation of inflammatory conditions. Recent observational studies have suggested a role for dermoscopy in identifying and differentiating acquired pig...

Ochronotic heart disease leading to severe aortic valve and coronary artery stenosis.
https://doi.org/10.1111/jocs.15738
Journal of Cardiac Surgery; Velez AK, Gaughan NA et. al.

Jun 14th, 2021 - Cardiac ochronosis is a rare disease, estimated to affect 1 in 250,000 persons. While there is extensive evidence of the musculoskeletal alterations of the disease, cardiac involvement has not been widely studied and most information we currently ...

Alkaptonuria - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/alkap/

Jun 10th, 2021 - Alkaptonuria is caused by deficiency of homogentisate 1,2-dioxygenase, an enzyme that converts homogentisic acid (HGA) to maleylacetoacetic acid in the tyrosine degradation pathway. The three major features of alkaptonuria are dark urine or urine ...

A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285993
Current Allergy and Asthma Reports; Chu P, Cuellar MC et. al.

Mar 6th, 2021 - Ochronosis and alkaptonuria are manifestations of the same condition-a rare autosomal recessive disorder resulting from a constitutional lack of homogentisate 1,2-dioxygenase (HGD) with the consequent accumulation of homogentisic acid (HGA). In oc...

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Clinicaltrials.gov  2 results

Study of Alkaptonuria
https://clinicaltrials.gov/ct2/show/NCT00005909

Feb 25th, 2020 - Alkaptonuria is a rare autosomal recessive disorder in which homogentisic acid accumulates and destroys connective tissue and bone, creating a condition called ochronosis. Symptoms generally begin in the third or fourth decade and progress to inca...

Long-Term Study of Nitisinone to Treat Alkaptonuria
https://clinicaltrials.gov/ct2/show/NCT00107783

Jan 19th, 2011 - Alkaptonuria is a rare metabolic disease in which homogentisic acid (HGA), an intermediary metabolite in tyrosine catabolism, accumulates due to deficiency of the enzyme homogentisic acid oxidase. Patients with alkaptonuria exhibit homogentisic ac...

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News  6 results

Incidentally Discovered Ochronosis Explaining Decades of Chronic Pain
https://www.mdedge.com/fedprac/article/215093/pain/incidentally-discovered-ochronosis-explaining-decades-chronic-pain/page/0/2?channel=285

Jan 7th, 2020 - Manipulating the metabolic pathway of phenylalanine with medication is a second option. An example of this is nitisinone, a US Food and Drug Administration-approved medication for treatment of tyrosinemia.

Localized Argyria With Pseudo-ochronosis
https://www.mdedge.com/dermatology/article/96357/dermatopathology/localized-argyria-pseudo-ochronosis
Kyle M. Devins, BS, Herman S. Mogavero Jr, MD et. al.

Jan 9th, 2015 - Localized cutaneous argyria often presents as asymptomatic black or blue-gray pigmented macules in areas of the skin exposed to silver-containing compounds. 1 Silver may enter the skin by traumatic implantation or absorption via eccrine sweat gland.

Skin of Color: Cosmeceutical Lightening Agents
https://www.mdedge.com/dermatology/article/52446/pigmentation-disorders/skin-color-cosmeceutical-lightening-agents

Apr 9th, 2012 - Dyspigmentation from acne or inflammatory skin disease is a frustrating problem for both patients and dermatologists. Postinflammatory hyperpigmentation can last up to 2 years without proper treatment.

On the Ocular Findings in Ochronosis
https://www.medscape.com/viewarticle/820497_4

Results Our literature search revealed 74 articles. Within them we found 36 relevant case reports including 40 patients published between 1942 and 2012. Excluded articles and respective reasons are given in Table 1. The mean age of our patients wa...

On the Ocular Findings in Ochronosis
https://www.medscape.com/viewarticle/820497

Abstract Background Ochronosis/Alkaptonuria is a tyrosine metabolism disorder where accumulation of homogentisic acid, in eye, skin, cartilage and several other connective tissues leads to a black pigmentation of the affected tissues. It is autoso...

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