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About 421 results

ALLMedicine™ Ochronosis Center

Research & Reviews  209 results

Cervical Myelopathy Due to Ochronosis: An Intraoperative Suspicion.
https://doi.org/10.12659/AJCR.924575
The American Journal of Case Reports; Alisi MS, Al-Saber MG et. al.

Sep 10th, 2020 - BACKGROUND Alkaptonuria (AKU) is a rare metabolic disease caused by a deficiency in homogentisic acid oxidase, which leads to the accumulation of homogentisic acid dark pigments in tissues such as bones, ligaments, and tendons. Long-term duration ...

Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach.
https://doi.org/10.1097/DAD.0000000000001571
The American Journal of Dermatopathology; Ho JD, Vashi N et. al.

Jul 23rd, 2020 - Exogenous ochronosis (EO) is a deposition disease associated with application of hydroquinone-containing preparations. Characteristic ochronotic bodies (OBs) arise from endogenous connective tissues, most often reported as collagen. We highlight a...

Cardiovascular ochronosis.
https://doi.org/10.1016/j.carpath.2020.107219
Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology; Ather N, Roberts WC

May 30th, 2020 - In this review, we summarize previously reported case reports (n=66) in which the presence of ochronotic pigment was found in one or more cardiovascular structures either at necropsy or after operative excision of a cardiac valve or portions of ar...

Study of Alkaptonuria
https://clinicaltrials.gov/ct2/show/NCT00005909

Feb 24th, 2020 - Alkaptonuria is a rare autosomal recessive disorder in which homogentisic acid accumulates and destroys connective tissue and bone, creating a condition called ochronosis. Symptoms generally begin in the third or fourth decade and progress to inca...

Presentation of 14 alkaptonuria patients from Turkey.
https://doi.org/10.1515/jpem-2019-0163
Journal of Pediatric Endocrinology & Metabolism : JPEM; Akbaba AI, Ozgül RK et. al.

Jan 13th, 2020 - Background Alkaptonuria (OMIM: 203500) is an inborn error of metabolism due to homogentisate 1,2-dioxygenase homogentisic acid 1,2 dioxygenase (HGD) enzyme deficiency. Due to the enzyme deficiency, homogentisic acid cannot be converted to maleylac...

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Clinicaltrials.gov  209 results

Cervical Myelopathy Due to Ochronosis: An Intraoperative Suspicion.
https://doi.org/10.12659/AJCR.924575
The American Journal of Case Reports; Alisi MS, Al-Saber MG et. al.

Sep 10th, 2020 - BACKGROUND Alkaptonuria (AKU) is a rare metabolic disease caused by a deficiency in homogentisic acid oxidase, which leads to the accumulation of homogentisic acid dark pigments in tissues such as bones, ligaments, and tendons. Long-term duration ...

Exogenous Ochronosis as an Elastotic Disease: A Light-Microscopic Approach.
https://doi.org/10.1097/DAD.0000000000001571
The American Journal of Dermatopathology; Ho JD, Vashi N et. al.

Jul 23rd, 2020 - Exogenous ochronosis (EO) is a deposition disease associated with application of hydroquinone-containing preparations. Characteristic ochronotic bodies (OBs) arise from endogenous connective tissues, most often reported as collagen. We highlight a...

Cardiovascular ochronosis.
https://doi.org/10.1016/j.carpath.2020.107219
Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology; Ather N, Roberts WC

May 30th, 2020 - In this review, we summarize previously reported case reports (n=66) in which the presence of ochronotic pigment was found in one or more cardiovascular structures either at necropsy or after operative excision of a cardiac valve or portions of ar...

Study of Alkaptonuria
https://clinicaltrials.gov/ct2/show/NCT00005909

Feb 24th, 2020 - Alkaptonuria is a rare autosomal recessive disorder in which homogentisic acid accumulates and destroys connective tissue and bone, creating a condition called ochronosis. Symptoms generally begin in the third or fourth decade and progress to inca...

Presentation of 14 alkaptonuria patients from Turkey.
https://doi.org/10.1515/jpem-2019-0163
Journal of Pediatric Endocrinology & Metabolism : JPEM; Akbaba AI, Ozgül RK et. al.

Jan 13th, 2020 - Background Alkaptonuria (OMIM: 203500) is an inborn error of metabolism due to homogentisate 1,2-dioxygenase homogentisic acid 1,2 dioxygenase (HGD) enzyme deficiency. Due to the enzyme deficiency, homogentisic acid cannot be converted to maleylac...

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News  3 results

Incidentally Discovered Ochronosis Explaining Decades of Chronic Pain
https://www.mdedge.com/fedprac/article/215093/pain/incidentally-discovered-ochronosis-explaining-decades-chronic-pain/page/0/2?channel=285

Jan 7th, 2020 - Manipulating the metabolic pathway of phenylalanine with medication is a second option. An example of this is nitisinone, a US Food and Drug Administration-approved medication for treatment of tyrosinemia.

Localized Argyria With Pseudo-ochronosis
https://www.mdedge.com/dermatology/article/96357/dermatopathology/localized-argyria-pseudo-ochronosis
Kyle M. Devins, BS, Herman S. Mogavero Jr, MD et. al.

Jan 9th, 2015 - Localized cutaneous argyria often presents as asymptomatic black or blue-gray pigmented macules in areas of the skin exposed to silver-containing compounds. 1 Silver may enter the skin by traumatic implantation or absorption via eccrine sweat gland.

Primary Multiple Miliary Osteoma Cutis and Exogenous Ochronosis
https://www.mdedge.com/dermatology/article/66664/primary-multiple-miliary-osteoma-cutis-and-exogenous-ochronosis
Bowman PH, Lesher Jl Jr

Multiple miliary osteoma cutis (MMOC), a rare disorder characterized by the appearance of numerous bony nodules on the face, was initially classified as a consequence of severe, long-standing acne vulgaris. However, several cases have now been des.

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