ALLMedicine™ Metabolic Disorders Center

Mar 27th, 2023 - Sacubitril-valsartan, a recently approved treatment for heart failure, has shown some promise as a possible therapeutic option for diabetes mellitus. It is still not clear whether those beneficial effects are comparable to valsartan effects. In th...

Mar 26th, 2023 - Metabolic physiology plays a key role in maintaining our health and resilience. Metabolic disorders can lead to serious illnesses, including obesity. The pathogenesis of the new long COVID syndrome in individuals with long-term recovery after SARS...

Mar 26th, 2023 - Betel nut chewing plays a role in the pathogenesis of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC). As the major active ingredient of the betel nut, the effect of arecoline and its underlying mechanism to OSF and OSCC path...

Mar 26th, 2023 - To investigate the clinical status of insulin resistance (IR) and its correlation with disease duration in patients with type 1 diabetes (T1D). Cross-sectional data from a T1D cohort were obtained (n=923). IR-related metabolic disorders including ...

Mar 26th, 2023 - Protein‒protein interactions (PPIs) are the foundation of the life activities of cells. TurboID is a biotin ligase with higher catalytic efficiency than BioID or APEX that reduces the required labeling time from 18 h to 10 min. Since many proteins...

Nov 28th, 2022 - Childhood ataxia may be due to multifactorial causes of impairment in the coordination of movement and balance. Acutely presenting ataxia in children may be due to infectious, inflammatory, toxic, ischemic, or traumatic etiology. Intermittent or e...

Apr 27th, 2022 - Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (A...

May 6th, 2019 - Acute changes in mental status represent a broad collection of symptoms used to describe disorders in mentation and level of arousal, including the more narrowly defined diagnoses of delirium and psychosis. A wide range of precipitating factors ma...

Mar 15th, 2018 - The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were p...

Apr 6th, 2012 - Biochemical genetic testing and newborn screening are essential laboratory services for the screening, detection, diagnosis, and monitoring of inborn errors of metabolism or inherited metabolic disorders. Under the Clinical Laboratory Improvement ...

Mar 21st, 2023 - Study Description: This protocol is designed to allow endocrine-related evaluations of children with known or suspected endocrine or metabolic disorders. Children with endocrine or metabolic-related condition(s) who may or may not be eligible for ...

Mar 10th, 2023 - This is an observational protocol designed to collect data from adult subjects with known or suspected endocrine or metabolic disorders. OBJECTIVE: The overall purpose of endocrine evaluations under this protocol is to increase knowledge of endocr...

Mar 9th, 2023 - 9-ING-41 is a first-in-class, intravenously administered, maleimide-based small molecule potent selective GSK-3β inhibitor with significant pre-clinical antitumor activity. GSK-3 is a serine/threonine kinase initially described as a key regulator ...

Mar 9th, 2023 - Immune-checkpoint inhibitors (ICI) now represent the backbone therapy for patients with advanced or unresectable non-small cell lung cancer (NSCLC) and metastatic melanoma. However, only a minority of patients obtain durable complete responses. In...

Mar 3rd, 2023 - Women with inherited metabolic disorders are reaching child bearing age more often due to advances in early diagnosis and improved pediatric care. For many of these disorders, there is very little information in the literature to guide the counsel...

Mar 22nd, 2023 - Into thin, but healthy, air Human civilization has essentially been built on proximity to water. Ancient civilizations in Mesopotamia, Egypt, Greece, China, and India were all intimately connected to either rivers or the ocean.

Jan 13th, 2023 - Gestational diabetes is a significant health problem worldwide that is associated with immediate and lifelong consequences for the affected woman and her infant. Gestational diabetes increases the risk for pregnancy-related complications, such as.

Dec 12th, 2022 - Patients with Class I obesity can be treated effectively with bariatric surgery, which reduces BMI and comorbidities over 5 years, according to a single-center study. In a retrospective analysis of patients who underwent bariatric surgery for Clas...

Nov 18th, 2022 - Older women who binge eat may be at increased risk for metabolic disorders such as diabetes and high cholesterol, according to research presented at the 2022 annual meeting of the Gerontological Society of America (GSA 2022). According to the Nati...

Nov 1st, 2022 - The FDA announced a voluntary recall of one lot of Mylan's octreotide acetate injection due to possible glass particles in the syringes. Could the nationwide semaglutide (Wegovy, Ozempic) shortage be due to its growing popularity across social med...