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ALLMedicine™ Vitamin K Deficiency Center

Research & Reviews  212 results

Neglected vitamin K deficiency causing coagulation dysfunction in an older patient with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338575
BMC Geriatrics; Wu Q, Wang L et. al.

Jul 31st, 2022 - The development of coagulation disorders can be dangerous and fatal in the older people, especially those with multiple medical conditions. Vitamin K-dependent coagulation disorders are easily overlooked when anticoagulant drugs are not used and t...

Hypoprothrombinemia During Cefmetazole Treatment: A Case Report.
https://doi.org/10.12659/AJCR.936712
The American Journal of Case Reports; Haba Y, Akizuki H et. al.

Jul 28th, 2022 - BACKGROUND Cefmetazole (CMZ), containing an N-methyl-tetrazole-thiol (NMTT) side chain, is a therapeutic option for diverticulitis in Japan. Cephems containing an NMTT, a methyl-thiadiazol, and a thiadiazolethiol side chain are known to induce coa...

Aetiological Profile and Short-Term Neurological Outcome of Haemorrhagic Stroke in Chil...
https://doi.org/10.1093/tropej/fmac040
Journal of Tropical Pediatrics; Sharma S, Suthar R et. al.

Jul 2nd, 2022 - Haemorrhagic stroke (HS) accounts for nearly half of the paediatric strokes. The aetiology of HS in childhood is not well defined in the Indian context. To study the aetiological profile and short-term neurological outcome of children with HS from...

GGCX mutants that impair hemostasis reveal the importance of processivity and full carb...
https://doi.org/10.1182/blood.2021014275
Blood Rishavy MA, Hallgren K et. al.

Jun 30th, 2022 - The gamma-glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout the multiple Glu carboxyl...

Prevalence and factors associated with vitamin K prophylaxis utilization among neonates...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229479
BMC Pediatrics; Negash BT, Alelgn Y

Jun 24th, 2022 - Neonatal Mortality Ratio (NMR) could not be reversed sufficiently in Ethiopia in the last couple of years. Neonatal bleeding is one of the major causes of neonatal deaths. Administration of vitamin K prophylaxis at birth is the proven strategy to ...

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Drugs  30 results see all →

Clinicaltrials.gov  7 results

Maternal and Neonatal Benefits of Prophylactic Administration of Vitamin K Before Elective Cesarean Section
https://clinicaltrials.gov/ct2/show/NCT04984083

Feb 15th, 2022 - Vitamin K deficiency can cause serious risks to pregnant women and their babies that may lead to hemorrhage, especially in newborns. We aim to evaluate the efficacy of vitamin k in decreasing blood loss during and after elective cesarean section (...

Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
https://clinicaltrials.gov/ct2/show/NCT04477811

Jul 21st, 2021 - Vascular calcification has emerged as an independent risk factor for cardiovascular morbidity and mortality, especially in chronic kidney disease . It has a predictive value of poor prognoses and clinical outcomes in CKD patients such as overall m...

Vitamin K1 to Slow Progression of Vascular Calcification in HD Patients
https://clinicaltrials.gov/ct2/show/NCT01742273

Oct 8th, 2020 - Patients on hemodialysis (HD) exhibit an immensely increased cardiovascular mortality associated with extensive vascular calcification (VC). This forms - at least partially - the reason for the excessively increased cardiovascular mortality in thi...

Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease
https://clinicaltrials.gov/ct2/show/NCT02094222

Feb 18th, 2019 - Byler Disease is the result of a homozygous missense (G308V) mutation in the ATP8B1 gene. The disease is typically manifest in the first year of life on the basis of complications of cholestasis; common presentations include jaundice, poor growth,...

Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study)
https://clinicaltrials.gov/ct2/show/NCT03813550

Feb 4th, 2019 - Vitamin K deficiency contributes to pathological calcification which underlies the clinical picture of pseudoxanthoma elasticum (PXE), an inherited autosomal recessive disease. A substantial proportion of vitamin K, namely the K2 form (menaquinone...

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News  21 results

Pediatrics Group Stresses Benefits of Vitamin K Shots for Infants
https://www.medscape.com/viewarticle/968916

Feb 22nd, 2022 - After the American Academy of Pediatrics (AAP) began recommending vitamin K shots for newborns in 1961, infant bleeding as a result of vitamin K deficiency plummeted. The life-threatening disorder is so rare that some parents now question the need...

PIVKA-II shows promise as HCC biomarker
https://www.mdedge.com/fedprac/article/240486/hepatocellular-carcinoma/pivka-ii-shows-promise-hcc-biomarker

May 24th, 2021 - Key clinical point: Increased levels of prothrombin induced by vitamin K deficiency or antagonist- II (PIVKA-II) identified patients with hepatocellular carcinoma (HCC). Major finding: Median PIVKA-II serum levels were significantly higher in pati.

Consider hepatitis D testing for patients receiving nucleoside analogues
https://www.mdedge.com/fedprac/article/240241/hepatocellular-carcinoma/clinical-edge-journal-scan-commentary-hcc-may-2021
Nevena Damjanov, MD

May 17th, 2021 - Nevena Damjanov, MD This month’s articles investigate earlier diagnosis of new or recurrent hepatocellular carcinoma (HCC). The first study looked at patients with hepatitis B virus (HBV) infection, trying to identify those at higher risk for deve.

Warfarin Use Linked to Knee and Hip Replacement in Osteoarthritis Patients
https://www.staging.medscape.com/viewarticle/940569

Nov 8th, 2020 - Patients who take the vitamin K antagonist warfarin to prevent thromboembolic events are significantly more likely to require knee or hip replacement surgery — a surrogate endpoint for end-stage osteoarthritis — than are patients who take direct o...

Warfarin use linked to knee and hip replacement in osteoarthritis patients
https://www.mdedge.com/rheumatology/article/231365/osteoarthritis/warfarin-use-linked-knee-and-hip-replacement
Neil Osterweil

Nov 7th, 2020 - Patients who take the vitamin K antagonist warfarin to prevent thromboembolic events are significantly more likely to require knee or hip replacement surgery – a surrogate endpoint for end-stage osteoarthritis – than are patients who take direct o.

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