ALLMedicine™ Parathyroid Carcinoma Center

Mar 25th, 2023 - Recent data suggest an increase in the overall incidence of parathyroid disorders with primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is associated with morbidities (fractures, kidney stones, chronic kidney ...

Mar 17th, 2023 - Parathyroid carcinoma (PC) is a rare endocrine malignancy with an increased incidence in the last decade. There is no reliable prognostic staging system for PC. Several hosts, tumors, and tumor microenvironment factors have been negatively correla...

Feb 23rd, 2023 - Parathyroid carcinoma (PC) is an ultra-rare malignancy with a high risk of recurrence after surgery. Tumor-directed systemic treatments for PC are not established. We used whole-genome and RNA sequencing in four patients with advanced PC to identi...

Feb 5th, 2023 - The purpose of this study was to examine the postoperative clinical course of parathyroid carcinoma to determine factors that predict postoperative recurrence and distant metastasis. In this retrospective study, we included 38 patients with parath...

Feb 3rd, 2023 - Thymic clear cell carcinoma is a rare mediastinal neoplasm, with only 25 reported cases to date. We report a case of a 45-year-old man with thymic clear cell carcinoma. We think imaging and laboratory tests may be helpful for differential diagnosi...

May 28th, 2009 - The present guidelines were issued by the Parathyroid Task Group of the European Association of Nuclear Medicine. The main focus was imaging of primary hyperparathyroidism. Dual-tracer and single-tracer parathyroid scintigraphy protocols were disc...

Jan 25th, 2023 - Hyperparathyroidism (HPT) is a clinical disorder characterized by an inappropriately elevated paratohormone (PTH) due to hypersecretion of one or more parathyroid glands, that may develop secondary hypercalcemia and other metabolic disturbances. T...

Apr 4th, 2022 - Hyperparathyroidism is an increasingly significant medical and public health condition in the United States. In the past two decades, the incidence of hyperparathyroidism has increased 300%, and currently, the disease affects at least 30,000 new p...

May 27th, 2021 - To evaluate the efficacy of KHK7580 orally administered up to 24 weeks for hypercalcemia in patient with parathyroid carcinoma or primary hyperparathyroidism who are unable to undergo parathyroidectomy or relapse after parathyroidectomy.

Jan 19th, 2021 - X-linked hypophosphatemic rickets (XLH) is an X-linked dominant genetic disorder. Common findings are low serum phosphate and inadequate 1,25(OH)2 vitamin D production. It is generally believed that the primary defect in XLH is impaired renal tubu...

Sep 7th, 2020 - PRIMARY OBJECTIVE: I. Objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 determined by Ia. Computed tomography (CT) or Ib. Magnetic resonance imaging (MRI). SECONDARY OBJECTIVES: I. To estimate progression-f...

Feb 21st, 2020 - Nephrocalcinosis is a condition characterized by the calcification of the renal tubules that leads to renal insufficiency. This occurs via metastatic calcification, which means that calcium is deposited in normal tissues, rather than those that ha...

Nov 1st, 2018 - Since the advent of multichannel serum chemistry screening in the 1970s, large numbers of asymptomatic cases of primary hyperparathyroidism (PHPT) have been discovered. The clinical spectrum of the disease has changed from the classic “moans, groa.

Feb 26th, 2013 - The FDA today suspended all pediatric clinical trials of cinacalcet hydrochloride (Sensipar) -- Amgen's calcium-sensing receptor agonist -- because of the death of a 14-year-old patient in one of the studies. The agency has not concluded that ther...

Feb 26th, 2013 - The US Food and Drug Administration (FDA) today announced that it has halted all pediatric clinical trials of cinacalcet (Sensipar, Amgen), a calcium-lowering drug, after the recent death of a 14-year-old patient in a study. The FDA decision to st...

Feb 28th, 2005 - Discussion The case of this unfortunate patient presents several points of interest. Brown tumors are rare, seen in fewer than 5% of patients with primary hyperparathyroidism today. Early detection of hypercalcemia due to rapid multichannel bioche...