ALLMedicine™ Pseudohypoparathyroidism Center
Research & Reviews 234 results
https://doi.org/10.1172/JCI167953
The Journal of Clinical Investigation; Iwasaki Y, Aksu C et. al.
Mar 1st, 2023 - Genetic defects of GNAS, the imprinted gene encoding the stimulatory G protein α-subunit, are responsible for multiple diseases. Abnormal GNAS imprinting causes pseudohypoparathyroidism type 1B (PHP1B), a prototype of mammalian end-organ hormone r...
https://doi.org/10.1007/s40618-023-02018-2
Journal of Endocrinological Investigation; Modica R, Liccardi A et. al.
Feb 12th, 2023 - Parathyroid diseases are related to parathyroid hormone (PTH) dysregulation by parathyroid cells or alteration of PTH function. They include hyperparathyroidism (PTH excess), hypoparathyroidism (PTH deficiency) and pseudohypoparathyroidism (PTH re...
https://doi.org/10.1002/mgg3.2144
Molecular Genetics & Genomic Medicine; Fei Y, Liu L et. al.
Jan 21st, 2023 - Pseudohypoparathyroidism (PHP) is a series of diseases related to pathological changes and neurocognitive and endocrine abnormalities, mainly due to the GNAS mutation on chromosome 20q13.2, which weakens receptor-mediated hormone signal transducti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858345
PloS One; Krishnan N, McMullan P et. al.
Jan 21st, 2023 - Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivating mutations in GNAS. Patients with maternally-inherited mutations develop pseudohypoparathyroidism type 1A (PHP1A) with multi-hormone resistance and aberrant craniofacia...
https://clinicaltrials.gov/ct2/show/NCT00001242
Jan 20th, 2023 - Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other pr...
Drugs 20 results see all →
Clinicaltrials.gov 16 results
https://clinicaltrials.gov/ct2/show/NCT00001345
Jan 20th, 2023 - Familial multiple endocrine neoplasia type 1 (MEN1), familial hypocalciuric (or familial benign) hypercalcemia (FHH), hyperparathyroidism - jaw tumor syndrome (HPT-JT), other causes of familial isolated hyperparathyroidism (FIHP), and pseudohypopa...
https://clinicaltrials.gov/ct2/show/NCT00001242
Jan 20th, 2023 - Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other pr...
https://clinicaltrials.gov/ct2/show/NCT04551170
Oct 5th, 2022 - Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS. The resultant hormone abnormalities can be treated with hormone replacement therapy, but ...
https://clinicaltrials.gov/ct2/show/NCT00209235
Oct 5th, 2022 - Pseudohypoparathyroidism type 1A (PHP1A) is a disorder that causes many endocrine and developmental problems. To date, medical treatment has focused primarily on maintenance of normal serum levels of calcium, phosphorous, and thyroid hormone. Howe...
https://clinicaltrials.gov/ct2/show/NCT03029429
Aug 16th, 2022 - Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS. The resultant hormone abnormalities can be treated with hormone replacement therapy, but ...
News 2 results
https://www.medpagetoday.com/endocrinology/growthdisorders/94889
Oct 6th, 2021 - GNAS mutations in kids with severe obesity may go undetected, researchers suggested. In a study of 2,548 children with severe obesity in whom genetic causes of obesity were not suspected, a total of 22 were found to have heterozygous GNAS mutation...
https://reference.medscape.com/viewarticle/857143_5
Jan 14th, 2016 - On initial presentation, exclusion of other diseases that result in a similar "bright bone" appearance on radiography is important. The causes of diffuse osteosclerosis include hypervitaminosis D, hypoparathyroidism, myelofibrosis, Paget disease, ...