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ALLMedicine™ Pseudohypoparathyroidism Center

Research & Reviews  234 results

The long-range interaction between two GNAS imprinting control regions delineates pseud...
https://doi.org/10.1172/JCI167953
The Journal of Clinical Investigation; Iwasaki Y, Aksu C et. al.

Mar 1st, 2023 - Genetic defects of GNAS, the imprinted gene encoding the stimulatory G protein α-subunit, are responsible for multiple diseases. Abnormal GNAS imprinting causes pseudohypoparathyroidism type 1B (PHP1B), a prototype of mammalian end-organ hormone r...

Parathyroid diseases and metabolic syndrome.
https://doi.org/10.1007/s40618-023-02018-2
Journal of Endocrinological Investigation; Modica R, Liccardi A et. al.

Feb 12th, 2023 - Parathyroid diseases are related to parathyroid hormone (PTH) dysregulation by parathyroid cells or alteration of PTH function. They include hyperparathyroidism (PTH excess), hypoparathyroidism (PTH deficiency) and pseudohypoparathyroidism (PTH re...

Whole-genome sequencing revealed a novel long-range deletion mutation spanning GNAS in ...
https://doi.org/10.1002/mgg3.2144
Molecular Genetics & Genomic Medicine; Fei Y, Liu L et. al.

Jan 21st, 2023 - Pseudohypoparathyroidism (PHP) is a series of diseases related to pathological changes and neurocognitive and endocrine abnormalities, mainly due to the GNAS mutation on chromosome 20q13.2, which weakens receptor-mediated hormone signal transducti...

Prevalence of Chiari malformation type 1 is increased in pseudohypoparathyroidism type ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9858345
PloS One; Krishnan N, McMullan P et. al.

Jan 21st, 2023 - Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivating mutations in GNAS. Patients with maternally-inherited mutations develop pseudohypoparathyroidism type 1A (PHP1A) with multi-hormone resistance and aberrant craniofacia...

Studies of States With Resistance to Vitamin D and Parathyroid Hormone
https://clinicaltrials.gov/ct2/show/NCT00001242

Jan 20th, 2023 - Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other pr...

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Drugs  20 results see all →

Clinicaltrials.gov  16 results

Studies of Inherited Diseases of Metabolism
https://clinicaltrials.gov/ct2/show/NCT00001345

Jan 20th, 2023 - Familial multiple endocrine neoplasia type 1 (MEN1), familial hypocalciuric (or familial benign) hypercalcemia (FHH), hyperparathyroidism - jaw tumor syndrome (HPT-JT), other causes of familial isolated hyperparathyroidism (FIHP), and pseudohypopa...

Studies of States With Resistance to Vitamin D and Parathyroid Hormone
https://clinicaltrials.gov/ct2/show/NCT00001242

Jan 20th, 2023 - Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other pr...

Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old
https://clinicaltrials.gov/ct2/show/NCT04551170

Oct 5th, 2022 - Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS. The resultant hormone abnormalities can be treated with hormone replacement therapy, but ...

Albright Hereditary Osteodystrophy: Natural History, Growth, and Cognitive/Behavioral Assessments
https://clinicaltrials.gov/ct2/show/NCT00209235

Oct 5th, 2022 - Pseudohypoparathyroidism type 1A (PHP1A) is a disorder that causes many endocrine and developmental problems. To date, medical treatment has focused primarily on maintenance of normal serum levels of calcium, phosphorous, and thyroid hormone. Howe...

Theophylline Treatment for Pseudohypoparathyroidism
https://clinicaltrials.gov/ct2/show/NCT03029429

Aug 16th, 2022 - Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS. The resultant hormone abnormalities can be treated with hormone replacement therapy, but ...

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News  2 results

'Unbiased' Genetic Screening Turns Up Cause of Kids' Obesity
https://www.medpagetoday.com/endocrinology/growthdisorders/94889

Oct 6th, 2021 - GNAS mutations in kids with severe obesity may go undetected, researchers suggested. In a study of 2,548 children with severe obesity in whom genetic causes of obesity were not suspected, a total of 22 were found to have heterozygous GNAS mutation...

A 49-Year-Old Man With Pain at the Site of a Previous Fracture
https://reference.medscape.com/viewarticle/857143_5

Jan 14th, 2016 - On initial presentation, exclusion of other diseases that result in a similar "bright bone" appearance on radiography is important. The causes of diffuse osteosclerosis include hypervitaminosis D, hypoparathyroidism, myelofibrosis, Paget disease, ...

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