Jul 31st, 2019 - Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female. It is often a sign of excessive androgen levels. Although many conditions can lead to hirsutism, polycystic ovary syndrome and idiopathic hyperandrogenism account for more than 85% of cases. Less common causes include idiopathic hirsutism, nonclassic congenital adrenal hyperplasia, androgen-secreting tumor...
Dec 4th, 2019 - The 2019 Guidelines for Management of Growth Hormone Deficiency in Adults and Patients Transitioning from Pediatric to Adult Care issued by two key US endocrine societies cover important developments in the decade since the previous version. The full text, by Kevin C.J. Yuen, MD, and colleagues, is available online in Endocrine Practice. Among other topics, the guidelines discuss currently ...
May 14th, 2019 - LOS ANGELES – Recent research, a new test, and upcoming guidelines are providing insight into the diagnosis of adult growth hormone deficiency and the importance of treatment, Kevin C. J.
Pablo Fernández-Crehuet, MD, PhD, Ricardo Ruiz-Villaverde, MD, PhD
Nov 30th, 2018 - To the Editor: A 58-year-old woman with a history of hyperprolactinemia and gastrointestinal angiodysplasia presented to the dermatology department with a generalized skin rash of 3 weeks’ duration. She did not have a history of toxic habits.
Nov 18th, 2018 - The Committee for Medicinal Products for Human Use of the European Medicines Agency (EMA) has issued a positive opinion on an orally available ghrelin agonist macimorelin (Macimorelin, Aeterna Zentaris) to be used in the diagnosis of patients with adult growth hormone deficiency. Adult growth hormone deficiency is a rare disorder characterized by the inadequate secretion of growth hormone from ...
Oct 1st, 2018 - 5 strategies for addressing hyperprolactinemia 1. Reduce the antipsychotic dose.
Aug 8th, 2018 - A blood test for copeptin, a precursor of antidiuretic hormone (ADH, vasopressin), differentiates between "harmless" polydipsia-polyuria and diabetes insipidus more quickly and accurately than a traditional water-deprivation test, researchers report. Measuring plasma levels of copeptin after a 2-hour saline infusion was more accurate than being deprived of fluids for 16 hours. The latter is a t...
Aug 1st, 2018 - Action Points A diagnostic test involving direct detection of plasma copeptin using a hypertonic saline infusion was more accurate than the traditional indirect water-deprivation test for diagnosing diabetes insipidus, according to an international, multicenter, prospective study. Note that the test involving direct detection of plasma copeptin using a hypertonic saline infusion was better able...
May 29th, 2018 - Diabetes insipidus is defined as the passage of large volumes of dilute urine. It has two major forms: central and nephrogenic. Central diabetes insipidus is characterized by decreased secretion of antidiuretic hormone (ADH), which gives rise to polyuria and polydipsia by diminishing the person's ability to concentrate urine. Nephrogenic diabetes insipidus is characterized by a decrease in the ...
Apr 26th, 2018 - CHICAGO – Management of fertility and reproduction for women with prolactin-secreting pituitary tumors is a balancing act, often in the absence of robust data to support clinical decision making. So judgment, communication, and paying attention to the patient become paramount considerations, said endocrinologist Mark Molitch, MD, speaking at the annual meeting of the Endocrine Society.
Hilary Navy, PharmD, BCGP, Kristen Gardner, PharmD, BCPP
Mar 1st, 2018 - Ms. E, age 23, presents to your office for a routine visit for management of bipolar I disorder and posttraumatic stress disorder with comorbid type 2 diabetes mellitus.
Dec 20th, 2017 - The US Food and Drug Administration (FDA) has approved an orally available ghrelin agonist, macimorelin (Macrilen, Aeterna Zentaris), to be used in the diagnosis of patients with adult growth-hormone deficiency (AGHD). Macimorelin stimulates the secretion of growth hormone from the pituitary gland into the circulatory system. Stimulated growth-hormone levels are measured in four blood samples o...
Dec 20th, 2017 - (Reuters) - Canada’s Aeterna Zentaris Inc said on Wednesday the U.S. Food and Drug Administration has approved its oral test to diagnose adult growth hormone deficiency. The company said it intends to launch the test, Macrilen, in the United States during the first quarter of 2018. Macrilen stimulates the secretion of growth hormone, which is then measured via blood samples. Aeterna said Macril...
Nov 20th, 2017 - PARIS – Many psychiatrists have no inkling of how often the antipsychotic agents they prescribe cause hyperprolactinemia-related sexual dysfunction, or the serious negative consequences these common side effects have on quality of life and treatment adherence, Ángel L. Montejo, MD, PhD, declared at the annual congress of the European College of Neuropsychopharmacology.
Sep 21st, 2017 - (Reuters) - Versartis Inc said its experimental drug for the treatment of growth hormone deficiency in children did not meet the main goal of a late-stage study, sending its shares tanking 85 percent. The drug, somavaratan, is a long-acting recombinant human growth hormone. The company said patients receiving somavaratan failed to show non-inferiority, compared with patients on Pfizer Inc’s dru...
Apr 27th, 2017 - LOS ANGELES — Treatment of residual nonfunctioning pituitary macroadenomas with Gamma Knife (Elekta) radiosurgery shows significantly greater benefit in reducing progression without an increase in endocrinopathies when used early after surgery compared with more than 6 months later in cases where clinicians opt for a "wait-and-watch" approach, according to new research. "We found a significantl...
Michele G. Sullivan
Apr 8th, 2017 - ORLANDO – About 80% of children with growth disorders will attain their expected normal adult height if adequately treated with growth hormone, a large observational study has determined. Somatropin recombinant human growth hormone seemed most effective for patients with growth hormone deficiency, idiopathic short stature, and for those who were born small for gestational age.
Dec 30th, 2016 - (Reuters) - OPKO Health Inc said its experimental drug for growth hormone deficiency (GHD) in adults failed to provide a statistically significant benefit over a placebo in a late-stage study, sending its shares down about 17 percent on Friday. Miami-based OPKO, which is developing the drug, hGH-CTP, with Pfizer Inc, said on Friday it had identified one or more outliers that may have affected t...
Oct 19th, 2016 - Patients with hypopituitarism should have their hormone levels restored as close to physiologic levels as possible, while taking into account potential interactions between hormones and other medications, say new guidelines on diagnosing and managing the syndrome. In its first clinical-practice guideline on the topic, the Endocrine Society states that the diagnosis and monitoring of the various...
Clinical Endocrinology News; Doug Brunk
Jan 7th, 2016 - Use of a novel reversible albumin-binding human growth hormone (GH) derivative administered subcutaneously once weekly for 4 weeks was safe and effective in adults with growth hormone deficiency, according to a phase I, randomized, open-label trial. Results from a recent clinical trial of the agent, known as NNC0195-0092 and being developed by Norvo Nordisk, indicated the feasibility of a once-.