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About 3,387 results

ALLMedicine™ Medullary Thyroid Carcinoma Center

Research & Reviews  1,669 results

Diagnostic Utility of INSM1 in Medullary Thyroid Carcinoma.
https://doi.org/10.1177/1066896921995935
International Journal of Surgical Pathology; Seok JY, Kang M et. al.

Mar 2nd, 2021 - Insulinoma-associated protein 1 (INSM1) is shown to be an excellent marker for neuroendocrine differentiation. However, the diagnostic utility of INSM1 in medullary thyroid carcinoma (MTC) has not yet been extensively investigated. INSM1 staining ...

The importance of the RET gene in thyroid cancer and therapeutic implications.
https://doi.org/10.1038/s41574-021-00470-9 10.1038/ncpendmet0717 10.1007/s40265-020-01343-7 10.1016/0092-8674(85)90115-1 10.1038/328528a0 10.1016/0092-8674(90)90659-3 10.1038/363458a0 10.1038/nm.2644 10.1038/nm.2673 10.1038/nm.2658 10.1530/ERC-18-0141 10.1530/ERC-17-0354 10.1158/2159-8290.CD-19-1116 10.1074/jbc.M605604200 10.1016/j.molcel.2014.01.015 10.1530/ERC-17-0297 10.1101/cshperspect.a009134 10.1126/science.287.5457.1489 10.1210/en.2005-1620 10.1038/sj.emboj.7601636 10.1038/nature05597 10.1073/pnas.1004520107 10.1038/nature13498 10.1016/j.celrep.2014.08.040 10.1016/j.molmed.2017.10.005 10.1016/j.cmet.2018.07.018 10.1038/nm.4394 10.1093/emboj/19.15.4056 10.1016/j.celrep.2016.11.061 10.1038/nrn2137 10.1136/jmg.2007.053959 10.1002/j.1460-2075.1996.tb00632.x 10.3389/fphys.2018.01873 10.1210/jc.2013-1204 10.1016/j.beem.2019.04.008 10.1530/EC-18-0157 10.1111/j.1365-2265.1995.tb01903.x 10.1089/thy.2011.0358 10.3390/genes10090698 10.1530/ERC-17-0325 10.1001/jama.1996.03540190047028 10.1038/ng0194-70 10.1126/science.7824936 10.1089/thy.2008.0403 10.1111/j.1365-2265.2010.03900.x 10.1530/ERC-17-0209 10.1016/S2213-8587(18)30336-X 10.1158/0008-5472.CAN-06-3329 10.1111/j.1349-7006.1999.tb00658.x 10.1210/jcem.87.1.8136 10.1158/0008-5472.CAN-06-0884 10.1002/hed.23241 10.1016/j.isci.2019.09.030 10.1159/000445978 10.1210/jc.2007-1714 10.1210/jc.2014-4153 10.1530/ERC-15-0070 10.1210/jc.2012-2703 10.1210/jc.2012-2092 10.3390/genes11040424 10.1016/j.cell.2014.09.050 10.1210/jc.2004-1811 10.1210/clinem/dgaa389 10.1089/thy.2019.0802 10.1089/thy.2019.0477 10.1172/JCI85271 10.1038/nrclinonc.2017.175 10.1038/s41467-018-07341-4 10.1093/annonc/mdy090 10.1038/ncomms4116 10.1097/PAS.0000000000001297 10.1016/j.humpath.2018.08.011 10.1097/PAS.0000000000001301 10.1038/leu.2012.109 10.1097/JTO.0000000000000135 10.1172/JCI69766 10.1158/0008-5472.CAN-09-4336 10.1200/JCO.2011.35.5040 10.1200/JCO.19.02551 10.1056/NEJMoa2005651 10.1056/NEJMoa2005653 10.1056/NEJMe2024831 10.1093/annonc/mdy137 10.1021/cb500129t 10.1016/j.beem.2017.04.013 10.1002/anie.201501104 10.1158/2159-8290.CD-18-0338 10.1200/JCO.2019.37.15_suppl.TPS3162 10.1093/annonc/mdz244.068 10.1038/sj.onc.1207810 10.1016/j.mce.2013.06.025 10.1677/ERC-08-0213 10.1111/bph.14395 10.1089/thy.2017.29050.sc.abstracts 10.1159/000477987 10.1016/j.jtho.2020.01.006 10.1158/1535-7163.MCT-16-0258 10.1074/jbc.RA119.007682 10.1038/s41467-018-02994-7 10.1158/1078-0432.CCR-18-4049 10.1016/S0140-6736(14)60421-9 10.1056/NEJMoa1406470 10.1200/JCO.2017.73.0226 10.1210/jc.2013-3713 10.1016/j.ejca.2017.01.029 10.1002/cncr.28766 10.1200/JCO.2012.48.4659 10.1200/JCO.19.02790 10.1530/ERC-19-0259 10.1089/thy.2014.0361 10.1158/1078-0432.CCR-15-1127 10.1093/annonc/mdx479 10.1530/ERC-16-0132 10.1158/0008-5472.CAN-06-4605 10.1200/JCO.2016.71.6472 10.1200/JCO.2020.38.15_suppl.109 10.1517/13543784.16.2.239 10.1158/1535-7163.MCT-11-0264 10.1158/1535-7163.MCT-08-0013 10.1038/nrd2130 10.1074/jbc.M703461200 10.1158/1078-0432.CCR-07-5270 10.1002/ijc.23131 10.1016/j.canlet.2013.07.007 10.1093/nar/gky995 10.1089/thy.2014.0335 10.1016/j.ctrv.2019.101911 10.1210/jc.2017-01039
Nature Reviews. Endocrinology; Salvatore D, Santoro M et. al.

Feb 19th, 2021 - Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein have been found in diverse thyroid cancer subtypes. RET gene rearrangements are observed in papillary thyroid carcinoma, which result in RET fusion produc...

Association of parental consanguinity with papillary thyroid carcinoma: a case-control ...
https://doi.org/10.1210/clinem/dgab071
The Journal of Clinical Endocrinology and Metabolism; Zayed AA, Amarin JZ et. al.

Feb 15th, 2021 - Papillary thyroid carcinoma (PTC) is the most common type of non-medullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental con...

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Guidelines  2 results

Consensus on management of advanced medullary thyroid carcinoma on behalf of the Workin...
https://doi.org/10.1007/s12094-015-1465-x
Clinical & Translational Oncology : Official Publication ... Grande E, Santamaría Sandi J et. al.

Dec 21st, 2015 - Of all thyroid cancers, <5 % are medullary (MTC). It is a well-characterized neuroendocrine tumor arising from calcitonin-secreting C cells, and RET gene plays a central role on its pathogeny. The electronic search was conducted using MEDLINE (Pub...

Revised American Thyroid Association guidelines for the management of medullary thyroid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490627
Thyroid : Official Journal of the American Thyroid Associ... Wells SA, Asa SL et. al.

Mar 26th, 2015 - The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association. The Task Force identified relevant articles using a systematic PubMed...

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Clinicaltrials.gov  1,695 results

Diagnostic Utility of INSM1 in Medullary Thyroid Carcinoma.
https://doi.org/10.1177/1066896921995935
International Journal of Surgical Pathology; Seok JY, Kang M et. al.

Mar 2nd, 2021 - Insulinoma-associated protein 1 (INSM1) is shown to be an excellent marker for neuroendocrine differentiation. However, the diagnostic utility of INSM1 in medullary thyroid carcinoma (MTC) has not yet been extensively investigated. INSM1 staining ...

The importance of the RET gene in thyroid cancer and therapeutic implications.
https://doi.org/10.1038/s41574-021-00470-9 10.1038/ncpendmet0717 10.1007/s40265-020-01343-7 10.1016/0092-8674(85)90115-1 10.1038/328528a0 10.1016/0092-8674(90)90659-3 10.1038/363458a0 10.1038/nm.2644 10.1038/nm.2673 10.1038/nm.2658 10.1530/ERC-18-0141 10.1530/ERC-17-0354 10.1158/2159-8290.CD-19-1116 10.1074/jbc.M605604200 10.1016/j.molcel.2014.01.015 10.1530/ERC-17-0297 10.1101/cshperspect.a009134 10.1126/science.287.5457.1489 10.1210/en.2005-1620 10.1038/sj.emboj.7601636 10.1038/nature05597 10.1073/pnas.1004520107 10.1038/nature13498 10.1016/j.celrep.2014.08.040 10.1016/j.molmed.2017.10.005 10.1016/j.cmet.2018.07.018 10.1038/nm.4394 10.1093/emboj/19.15.4056 10.1016/j.celrep.2016.11.061 10.1038/nrn2137 10.1136/jmg.2007.053959 10.1002/j.1460-2075.1996.tb00632.x 10.3389/fphys.2018.01873 10.1210/jc.2013-1204 10.1016/j.beem.2019.04.008 10.1530/EC-18-0157 10.1111/j.1365-2265.1995.tb01903.x 10.1089/thy.2011.0358 10.3390/genes10090698 10.1530/ERC-17-0325 10.1001/jama.1996.03540190047028 10.1038/ng0194-70 10.1126/science.7824936 10.1089/thy.2008.0403 10.1111/j.1365-2265.2010.03900.x 10.1530/ERC-17-0209 10.1016/S2213-8587(18)30336-X 10.1158/0008-5472.CAN-06-3329 10.1111/j.1349-7006.1999.tb00658.x 10.1210/jcem.87.1.8136 10.1158/0008-5472.CAN-06-0884 10.1002/hed.23241 10.1016/j.isci.2019.09.030 10.1159/000445978 10.1210/jc.2007-1714 10.1210/jc.2014-4153 10.1530/ERC-15-0070 10.1210/jc.2012-2703 10.1210/jc.2012-2092 10.3390/genes11040424 10.1016/j.cell.2014.09.050 10.1210/jc.2004-1811 10.1210/clinem/dgaa389 10.1089/thy.2019.0802 10.1089/thy.2019.0477 10.1172/JCI85271 10.1038/nrclinonc.2017.175 10.1038/s41467-018-07341-4 10.1093/annonc/mdy090 10.1038/ncomms4116 10.1097/PAS.0000000000001297 10.1016/j.humpath.2018.08.011 10.1097/PAS.0000000000001301 10.1038/leu.2012.109 10.1097/JTO.0000000000000135 10.1172/JCI69766 10.1158/0008-5472.CAN-09-4336 10.1200/JCO.2011.35.5040 10.1200/JCO.19.02551 10.1056/NEJMoa2005651 10.1056/NEJMoa2005653 10.1056/NEJMe2024831 10.1093/annonc/mdy137 10.1021/cb500129t 10.1016/j.beem.2017.04.013 10.1002/anie.201501104 10.1158/2159-8290.CD-18-0338 10.1200/JCO.2019.37.15_suppl.TPS3162 10.1093/annonc/mdz244.068 10.1038/sj.onc.1207810 10.1016/j.mce.2013.06.025 10.1677/ERC-08-0213 10.1111/bph.14395 10.1089/thy.2017.29050.sc.abstracts 10.1159/000477987 10.1016/j.jtho.2020.01.006 10.1158/1535-7163.MCT-16-0258 10.1074/jbc.RA119.007682 10.1038/s41467-018-02994-7 10.1158/1078-0432.CCR-18-4049 10.1016/S0140-6736(14)60421-9 10.1056/NEJMoa1406470 10.1200/JCO.2017.73.0226 10.1210/jc.2013-3713 10.1016/j.ejca.2017.01.029 10.1002/cncr.28766 10.1200/JCO.2012.48.4659 10.1200/JCO.19.02790 10.1530/ERC-19-0259 10.1089/thy.2014.0361 10.1158/1078-0432.CCR-15-1127 10.1093/annonc/mdx479 10.1530/ERC-16-0132 10.1158/0008-5472.CAN-06-4605 10.1200/JCO.2016.71.6472 10.1200/JCO.2020.38.15_suppl.109 10.1517/13543784.16.2.239 10.1158/1535-7163.MCT-11-0264 10.1158/1535-7163.MCT-08-0013 10.1038/nrd2130 10.1074/jbc.M703461200 10.1158/1078-0432.CCR-07-5270 10.1002/ijc.23131 10.1016/j.canlet.2013.07.007 10.1093/nar/gky995 10.1089/thy.2014.0335 10.1016/j.ctrv.2019.101911 10.1210/jc.2017-01039
Nature Reviews. Endocrinology; Salvatore D, Santoro M et. al.

Feb 19th, 2021 - Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein have been found in diverse thyroid cancer subtypes. RET gene rearrangements are observed in papillary thyroid carcinoma, which result in RET fusion produc...

Association of parental consanguinity with papillary thyroid carcinoma: a case-control ...
https://doi.org/10.1210/clinem/dgab071
The Journal of Clinical Endocrinology and Metabolism; Zayed AA, Amarin JZ et. al.

Feb 15th, 2021 - Papillary thyroid carcinoma (PTC) is the most common type of non-medullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental con...

see more →

News  21 results

BLU-667: New Hope for NSCLC and Medullary Thyroid Cancer
https://www.staging.medscape.com/viewarticle/895225

Apr 15th, 2018 - CHICAGO — Point mutations or gene rearrangements in the receptor tyrosine kinase proto-oncogene RET have been seen in several tumors, including medullary thyroid carcinoma (MTC) and non–small cell lung cancer (NSCLC). However, there are no approve...

BLU-667: New Hope for NSCLC and Medullary Thyroid Cancer
https://www.medscape.com/viewarticle/895225

Apr 15th, 2018 - CHICAGO — Point mutations or gene rearrangements in the receptor tyrosine kinase proto-oncogene RET have been seen in several tumors, including medullary thyroid carcinoma (MTC) and non–small cell lung cancer (NSCLC). However, there are no approve...

Scapular rash and endocrine neoplasia
https://www.mdedge.com/ccjm/article/150352/dermatology/scapular-rash-and-endocrine-neoplasia?channel=162
Muhammed Razmi T, MD, DNB, Debajyoti Chatterjee, MD et. al.

Nov 1st, 2017 - A woman in her 30s presented with an itchy skin-colored rash over her left scapular region that had first appeared 8 years earlier. It had started as itchy skin-colored papules that coalesced to a patch and later became hyperpigmented because of r.

Thyroid Ca: Initial Neck Dissection May Cut Recurrence Risk
https://www.medpagetoday.com/endocrinology/thyroid/68165

Sep 27th, 2017 - Action Points Among those with medullary thyroid carcinoma (MTC), lymph node dissection seemed to decrease local recurrences. Note that guidelines from the American Thyroid Association recommend all patients with known MTC undergo surgery to remov...

Renal cell carcinoma approval adds another notch to cabozantinib’s belt
https://www.mdedge.com/hematology-oncology/article/118588/genitourinary-cancer/renal-cell-carcinoma-approval-adds-another
Edited by Jame Abraham, MD et. al.

Nov 21st, 2016 - In April this year, the US Food and Drug Administration awarded regulatory approval to cabozantinib for the treatment of advanced renal cell carcinoma patients previously treated with anti-angiogenic therapy. 1 The small-molecule inhibitor, which.

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