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About 2,013 results

ALLMedicine™ Medullary Thyroid Carcinoma Center

Research & Reviews  717 results

Tumor Grade Predicts for Calcitonin Doubling Times and Disease-Specific Outcomes After ...
https://doi.org/10.1089/thy.2022.0217
Thyroid : Official Journal of the American Thyroid Associ... Nigam A, Xu B et. al.

Aug 12th, 2022 - Background: Tumor grade is a new validated prognostic factor for medullary thyroid cancer (MTC). Calcitonin doubling time can predict MTC recurrence. We aimed to describe the association of tumor grade with calcitonin doubling and its effect on di...

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
https://doi.org/10.6004/jnccn.2022.0040
Journal of the National Comprehensive Cancer Network : JN... Haddad RI, Bischoff L et. al.

Aug 11th, 2022 - Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in ...

A Retrospective Evaluation of the Diagnostic Performance of an Interdependent Pairwise ...
https://doi.org/10.1089/thy.2022.0124
Thyroid : Official Journal of the American Thyroid Associ... Finkelstein S, Sistrunk J et. al.

Aug 10th, 2022 - Addition of genetic analysis to the evaluation of thyroid nodule fine-needle aspiration biopsy (FNAB) samples improves diagnostic accuracy of cytologically indeterminate thyroid nodules (ITN) with Bethesda III or IV cytopathology. We previously re...

Natural History Study of Children and Adults With Medullary Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT01660984

Aug 9th, 2022 - Background: Medullary Thyroid Carcinoma (MTC) is a calcitonin producing tumor arising from the parafollicular C cells of thyroid. In children and adults, MTC is usually seen in association with Multiple Endocrine Neoplasia (MEN) 2A and 2B, which a...

MANAGEMENT OF ENDOCRINE DISEASE: Medullary thyroid cancer: from molecular biology and t...
https://doi.org/10.1530/EJE-22-0312
European Journal of Endocrinology; Saltiki K, Simeakis G et. al.

Jul 28th, 2022 - During the last decades, knowledge of the molecular biology in medullary thyroid carcinoma (MTC) and specifically on the role of rearranged during transfection (RET)-activating mutations in tumorigenesis has led to the evolution of novel targeted ...

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Guidelines  1 results

Revised American Thyroid Association guidelines for the management of medullary thyroid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490627
Thyroid : Official Journal of the American Thyroid Associ... Wells SA, Asa SL et. al.

Mar 27th, 2015 - The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association. The Task Force identified relevant articles using a systematic PubMed...

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Clinicaltrials.gov  34 results

Natural History Study of Children and Adults With Medullary Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT01660984

Aug 9th, 2022 - Background: Medullary Thyroid Carcinoma (MTC) is a calcitonin producing tumor arising from the parafollicular C cells of thyroid. In children and adults, MTC is usually seen in association with Multiple Endocrine Neoplasia (MEN) 2A and 2B, which a...

ImmunoTEP for Patients With Medullary Thyroid Carcinoma.
https://clinicaltrials.gov/ct2/show/NCT01730638

Jul 26th, 2022 - Variation of TF2 molar dose, IMP-288 molar dose and pretargeting interval will be performed in 4 to 5 cohorts of 3 patients, receiving 30 to 120 nmol of TF2 and 1.5 to 6 nmol of peptides 1 to 3 days apart. Blood samples will be obtained after TF2 ...

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer
https://clinicaltrials.gov/ct2/show/NCT00390325

Jul 19th, 2022 - PRIMARY OBJECTIVES: I. To assess objective response rate of sorafenib tosylate (sorafenib [BAY 43-9006]) in metastatic medullary thyroid carcinoma in setting of inherited tumor syndromes, such as multiple endocrine neoplasia (MEN) 2A, MEN 2B, or f...

177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer.
https://clinicaltrials.gov/ct2/show/NCT02088645

May 24th, 2022 - The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors. This receptors sho...

A Study of HA121-28 Tablets in Patients With Medullary Thyroid Carcinoma (MTC)
https://clinicaltrials.gov/ct2/show/NCT04787328

Feb 23rd, 2022 - A total of approximately 30 patients with MTC will be enrolled. The patients will undergo a 3 weeks-on and 1week-off treatment scheme with HA121-28 tablets 450 mg orally once daily in the 28-day cycle until disease progression or intolerable toxic...

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News  53 results

CAR T-Cell Therapy May Represent a New Option in Medullary Thyroid Cancer
https://www.onclive.com/view/car-t-cell-therapy-may-represent-a-new-option-in-medullary-thyroid-cancer

May 5th, 2022 - Investigators at the Perelman School of Medicine at the University of Pennsylvania (Penn) have recently initiated a clinical trial evaluating a novel CAR T-cell therapy in an effort to fill an unmet need for systemic treatment for patients with ad...

Mutation testing recommended for advanced and refractory thyroid cancer
https://www.mdedge.com/hematology-oncology/article/253582/head-neck/thyroid-cancers/mutation-testing-recommended-advanced
Jim Kling

Apr 8th, 2022 - A new consensus statement from the American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group focuses on a definition of advanced thyroid cancer and outlines strategies for mutation testing and targeted treat.

All About Wegovy for Weight Loss
https://www.medscape.com/viewarticle/953059

Jun 21st, 2021 - This transcript has been edited for clarity. Hi. Today we're going to talk about another form of semaglutide. This form is called Wegovy, and it's indicated for weight loss in people with or without diabetes. It's a higher dose than we've used bef...

Investigational Therapies for Thyroid Cancer
https://www.onclive.com/view/investigational-therapies-for-thyroid-cancer

Apr 2nd, 2021 - For High-Definition, Click Beyond sorafenib and lenvatinib, other agents have also shown a clinical activity in the thyroid cancer setting, states Robert I. Haddad, MD. Some of these agents are currently available, while others are still in the ...

RET Joins the Ranks of Actionable Targets in Precision Oncology
https://www.onclive.com/view/ret-joins-the-ranks-of-actionable-targets-in-precision-oncology

Feb 1st, 2021 - Over the past 2 decades, a growing number of targetable tumor-specific molecular alterations have been identified, ushering in the era of precision oncology.1 Now, alterations in the RET gene can be added to the list of druggable targets.2,3 RET ...

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