ALLMedicine™ Hypercholesterolemia Center

Mar 28th, 2023 - Epilepsy has been associated with cognitive impairment and potentially dementia in older individuals. However, the extent to which epilepsy may increase dementia risk, how this compares with other neurological conditions, and how modifiable cardio...

Mar 27th, 2023 - Homozygous familial hypercholesterolemia (FH) is a rare disease that causes serious cardiovascular problems and may be fatal even at an early age. Because this disease variant is rather aggressive, the effect of lipid-lowering agents and lipid aph...

Mar 26th, 2023 - Familial hypercholesterolemia (FH) is an inherited disease which causes premature atherosclerotic cardiovascular disease. However, less than 10% of individuals with FH have been identified. To assess parental perspectives for inclusion of FH on ro...

Mar 26th, 2023 - To investigate the relationship between renal artery anatomical configuration and renal artery plaque (RAP) based on 320-row CT. The abdominal contrast-enhanced CT data from 210 patients was retrospectively analyzed. Among 210 patients, there were...

Mar 26th, 2023 - In many countries, the prevalence of non-communicable diseases risk factors is commonly assessed through self-reported information from health interview surveys. It has been shown, however, that self-reported instead of objective data lead to an u...

Aug 13th, 2022 - Atherosclerosis begins in youth and is directly linked with the presence and severity of cardiovascular risk factors, including dyslipidemia. Thus, the timely identification and management of dyslipidemia in childhood might slow atherosclerotic pr...

Jul 24th, 2021 - Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). Choice of treatment should be based on the assessment of clinical activity and severity of GO. Early referral to specialized centers is fundamental for most...

Jan 4th, 2021 - The use of lorlatinib, an anaplastic lymphoma kinase (ALK) inhibitor for the treatment of ALK-positive metastatic non-small cell lung cancer, is associated with dyslipidemia in over 80% of patients. Clinical trial protocols for the management of l...

Dec 12th, 2018 - Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are...

Dec 14th, 2016 - Evidence showed that LDL-cholesterol lowering is associated with a significant cardiovascular risk reduction. The initial therapeutic approach to hypercholesterolemia includes dietary modifications but the compliance to recommendations is often in...

Mar 23rd, 2023 - Aim 1. Conduct interviews with patients with high cholesterol and/or FH and clinicians to identify common barriers and facilitators for individuals to engage in cascade screening. These activities will occur in the first 7 months and will serve as...

Mar 17th, 2023 - Detailed information of "standard of care" procedures will be compiled in a database. These include medical history and physical exam, lipid profiles and other standard blood tests, dietary evaluation and counseling, cardiology evaluation includin...

Mar 10th, 2023 - Hypercholesterolemia is a risk factor for the occurrence and development of atherosclerosis. Recent animal studies have found that increased serum cholesterol level is associated with peripheral Treg cell senescence, but clinical evidence is still...

Mar 9th, 2023 - Homozygous Familial Hypercholesterolemia (HoFH) is a rare genetic metabolic disorder characterized by absent or severely reduced capacity to catabolize circulating LDL particles by the hepatic LDL receptor. As a consequence, HoFH subjects present ...

Mar 9th, 2023 - This is multisite, randomized, double-blind, placebo-controlled, multidose regimen, phase 1, first-in-human study of VXX-401, a synthetic peptide-based active immunotherapy candidate for preventing and treating hypercholesterolemia. The study will...

Mar 23rd, 2023 - Note that some links may require subscriptions. Four new countries are reporting cholera outbreaks, bringing the total number of affected countries to 24, according to the World Health Organization. Come May, the White House COVID-19 task force wi...

Mar 15th, 2023 - Sex differences in adult heart disease may be related to diverging trajectories in cardiometabolic disease factors beginning as early as childhood, a metabolomics study showed. With granular and high-resolution cardiovascular phenotyping, the diff...

Feb 28th, 2023 - Meta-analysis makes the case for insomnia as a risk factor for myocardial infarction. (Clinical Cardiology) Outpatient procedures associated with postoperative heart attacks included gastrointestinal endoscopy, as well as vascular, urological/gyne...

Feb 10th, 2023 - Ozempic and Wegovy are two prescription drugs that have transformed the management of type 2 diabetes and obesity. Both are a form of semaglutide; the Food and Drug Administration approved Ozempic for treating type 2 diabetes in 2017, followed by.

Feb 9th, 2023 - HMG-CoA reductase inhibitors (statins) have been shown to effectively reduce low-density lipoprotein cholesterol (LDL-C) as well as morbidity and mortality in patients who have either atherosclerotic cardiovascular disease (ASCVD) or risk factors.