ALLMedicine™ Cirrhosis Center

Jan 16th, 2022 - To determine the performance of quantification of liver extracellular volume fraction (fECV) using dual-energy CT (DECT) compared with CT imaging for ruling out high-riskesophageal varices(HRV) in cirrhotic patients. We retrospectively analyzed 22...

Jan 16th, 2022 - The Controlling Nutritional Status (CONUT) score is designed to assess the immune-nutritional status of patients. Poor nutritional status and inflammation may facilitate the development of hepatic encephalopathy (HE) in cirrhotic patients. However...

Jan 15th, 2022 - Aberrant DNA methylation may offer opportunities in revolutionizing cancer screening and diagnosis. We sought to identify a non-invasive DNA methylation-based screening approach using cell-free DNA (cfDNA) for early detection of hepatocellular car...

Jan 15th, 2022 - Artificial intelligence (AI) is revolutionizing big data analytics. In this issue of AJG, Ahn et al. introduce the AI-Cirrhosis-ECG (ACE) score which can grade the electrophysiologic cardiac changes present in patients with cirrhosis. Apart from s...

Jan 15th, 2022 - We evaluated the COVID-19 pandemic's impact on HCC screening and diagnosis among patients with cirrhosis in the Veterans Health Administration. Rates and predictors of screening and diagnosis were reviewed 9/1/2019-2/29/2020 ("pre-COVID-19",N=94,6...

Sep 29th, 2021 - AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis.|2021|O'Shea RS,Davitkov P,Ko CW,Rajasekhar A,Su GL,|

Sep 29th, 2021 - AGA Technical Review on Coagulation in Cirrhosis.|2021|Intagliata NM,Davitkov P,Allen AM,Falck-Ytter YT,Stine JG,|

Aug 1st, 2021 - Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis/cirrhosis in asymptomatic patients at risk of developing clinically significant portal hypertension (CSPH, defined by a hepatic venous pressure gradient...

Aug 1st, 2021 - Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease and alpha-1 antitrypsin deficiency must be investigated in any patient with unexplained liver disease. Cystic fibrosis ...

Aug 1st, 2021 - Primary biliary cholangitis (PBC) is a chronic inflammatory disease of the intra-hepatic bile ducts [1]. It is characterised biologically by chronic cholestasis associated with the presence of specific autoantibodies, and histologically by lesions...

Jan 14th, 2022 - This is a multicenter, randomized, double-blind, placebo-controlled trial involving subjects with NASH cirrhosis and severe portal hypertension (defined as HVPG ≥12 mmHg as determined by the central reader assigned to this study). Upon successful ...

Jan 13th, 2022 - Background information Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in the liver and is defined by evidence of hepatic steatosis (via imaging or histology) and is not due to secondary liver fat accumulat...

Jan 13th, 2022 - Background NonAlcoholic Fatty Liver Disease (NAFLD) is one of the most commonly encountered liver disorders worldwide. NAFLD is a spectrum of liver disease including (i) simple hepatic steatosis also called Non-Alcoholic Fatty Liver (NAFL) and (ii...

Jan 12th, 2022 - This is a general clinical research protocol to allow for evaluation, investigation and long-term follow up of patients who have an acute or chronic liver disease. The protocol is designed to study the natural history and pathogenesis of various l...

Jan 11th, 2022 - The combination of hepatocellular carcinoma and chronic liver disease represents a dual impact on overall metabolism. The major risk factors for chronic liver disease related-hepatocellular carcinoma (HCC) include nonalcoholic fatty liver disease ...

Jan 11th, 2022 - A majority of long-COVID patients who had been hospitalized for severe COVID-19 illness had metabolic (dysfunction)-associated fatty liver disease (MAFLD), a retrospective study from Italy found. In an analysis of 235 patients presenting to a post...

Dec 22nd, 2021 - Following years of negative clinical trials and little advancement, the incorporation of frontline immunotherapy regimens has reshaped the treatment landscape of several gastrointestinal (GI) malignancies, including upper GI cancers and hepatocell...

Dec 16th, 2021 - A home-based tunneled peritoneal catheter (PeCa) drainage system provided significant relief for patients with refractory ascites who were not candidates for transjugular intrahepatic portosystemic shunt (TIPS). For these patients, the current sta...

Dec 14th, 2021 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills us...

Dec 13th, 2021 - Fibrosis-4 index (FIB-4) scores are strongly associated with severe liver disease outcomes in a primary care population, both in patients with known chronic liver disease and those without known CLD. The result could help identify patients with CL...