ALLMedicine™ Tuberculosis Center

Mar 28th, 2023 - Isoniazid (INH) plays an important role in prevention and treatment of tuberculosis (TB). However, large pharmacokinetic (PK) variations are observed in patients receiving standard INH dosages. Considering the influence of PK variations on INH eff...

Mar 28th, 2023 - The tuberculin skin test is commonly used to diagnose latent tuberculosis infection (LTBI) in resource-limited settings, but its specificity is limited by factors including cross-reactivity with BCG vaccine and environmental mycobacteria. Interfer...

Mar 28th, 2023 - Tuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a large proportion of genetic risk for adult pulmonary TB, and even fewer have examined gen...

Mar 28th, 2023 - Retrospective study. The aim of this study was to develop a predictive model for determining perioperative blood transfusion in tuberculous spondylitis patients undergoing posterior decompression and instrumentation. Tuberculous spondylitis is a c...

Mar 27th, 2023 - Rapid diagnosis of tuberculosis and drug resistance in extrapulmonary specimens can be challenging. The BD MAX™ multidrug resistant (MDR)-TB assay (BD MAX™) has demonstrated high sensitivity and specificity for the detection of the Mycobacterium t...

Mar 27th, 2022 - The European AIDS Clinical Society (EACS) Guidelines were revised in 2021 for the 17th time with updates on all aspects of HIV care. Version 11.0 of the Guidelines recommend six first-line treatment options for antiretroviral treatment (ART)-naïve...

Mar 21st, 2022 - The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatmen...

Feb 25th, 2022 - On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Trials Group (ACTG) published results from a randomized controlled trial indicating that a 4-month regimen containing rifapent...

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other t...

Sep 6th, 2020 - New evidence and knowledge about the clinical management of drug-resistant tuberculosis (TB) in the last 3 years, makes it necessary to update the recent guideline published by SEPAR in 2017, mainly in relation to new diagnostic methods, drug clas...

Mar 22nd, 2023 - This study is a multi-center, prospective, randomized, placebo-controlled, participant and laboratory-blinded clinical trial to evaluate a single pre-travel vaccination with investigational freeze-dried glutamate BCG (Japan) to prevent Mycobacteri...

Mar 17th, 2023 - Mycobacterium tuberculosis (MTB) is a slow-growing bacterium that establishes latent infection in millions of persons worldwide, but only leads to disease in 10% or less of these individuals. It typically causes pneumonia, however dissemination to...

Mar 15th, 2023 - Familial adenomatous polyposis (FAP) is the most common polyposis syndrome. It is an autosomal dominant inherited disorder characterized by the early onset of hundreds to thousands of adenomatous polyps throughout the colon. JNJ-64251330 (lorpucit...

Mar 14th, 2023 - The proposed DIAMA (DIAgnostics for Multidrug resistant tuberculosis in Africa) study aims to address current gaps in the diagnosis and management of patients with Multi-Drug-Resistant (MDR) tuberculosis. Building on existing networks and research...

Mar 10th, 2023 - This trial is designed to determine whether modifying the dose of isoniazid for individuals according to their n-acetyltransferase 2 (NAT2) genotype could increase the probability of achieving equivalence of area-under-the-curve.

Mar 24th, 2023 - Tuberculosis (TB) case counts in the U.S. increased to near pre-pandemic numbers in 2022, according to preliminary surveillance data from the CDC. With a 5% increase over the year prior, a total of 8,300 cases were recorded in 2022, for an inciden...

Learn about your risk for TB and talk to your healthcare provider about getting tested.

Mar 6th, 2023 - Note that some links may require subscriptions. President Biden's doctor, Kevin O'Connor, DO, said the skin lesion removed from the president's chest was a basal cell carcinoma, a common type of skin cancer. (AP) The White House called efforts to ...

An infographic titled Did You Know? with an illustration of lungs, medication bottles, and medication. Text says "There is a new 4-month treatment option for people with tuberculosis (TB) disease in the US. This new option: treats TB in two-thirds...

Feb 17th, 2023 - According to the Centers for Disease Control and Preventions, in 2019 2. 1% of all infants born in the United States were conceived by assisted reproductive technology (ART).