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About 16,480 results

ALLMedicine™ Gout Center

Research & Reviews  6,613 results

Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone.
https://doi.org/10.1124/molpharm.120.000086
Molecular Pharmacology; Tang LWT, Verma RK et. al.

Jan 13th, 2021 - Benzbromarone (BBR), a potent uricosuric agent for the management of gout, is known to cause fatal fulminant hepatitis. While the mechanism of BBR-induced idiosyncratic hepatotoxicity remains unelucidated, cytochrome P450 enzyme (CYP450)-mediated ...

An unusual presentation of erosive gout.
https://doi.org/10.1002/art.41641
Arthritis & Rheumatology (Hoboken, N.J.); Kharouf F, Azraq Y et. al.

Jan 11th, 2021 - A 44-year-old male presented with a 4-week history of painful contractures in both elbows and left knee. His medical record was notable for metabolic syndrome and antiphospholipid syndrome, with a previous extensive right leg thrombotic event, nec...

Post-hoc analysis of pegloticase pivotal trials in chronic refractory gout: relationshi...
https://www.ncbi.nlm.nih.gov/pubmed/33427618
Clinical and Experimental Rheumatology; Mandell BF, Fields TR et. al.

Jan 11th, 2021 - To determine factors associated with gout flares in subjects treated with pegloticase. Gout flares from two randomised controlled trials comparing pegloticase (8 mg every 2 weeks [q2] or monthly [q4]) versus placebo were analysed. Responders had p...

Sodium molybdate induces heterophil extracellular traps formation in chicken.
https://doi.org/10.1016/j.ecoenv.2020.111886
Ecotoxicology and Environmental Safety; Jiang A, Zhang Y et. al.

Jan 9th, 2021 - Molybdenum (Mo) is not only an important rare metal that is widely used in industrial production but also an essential trace element for plants and animals. Nevertheless, in Mo polluted areas, excess Mo intake will not only cause gout in humans bu...

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Guidelines  47 results

Comparative Performances of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Gout in Type 2 Diabetes
https://www.rheumatologyadvisor.com/home/conference-highlights/acr-convergence-2020/comparative-performance-of-sglt2-inhibitors-in-reducing-gout-in-t2d/

Nov 8th, 2020 - Among patients with type 2 diabetes (T2D), sodium-glucose cotransporter-2 (SGLT2) inhibitors dapagliflozin and empagliflozin vs canagliflozin show greater benefit in reducing gout, according to research results presented at the American College of...

Managing Gout
https://www.jwatch.org/na51787/2020/06/11/managing-gout
NEJM Journal Watch;

Jun 10th, 2020 - The ACR has updated its 2012 guideline on managing gout. Each recommendation is rated as “strong” (supported by moderate- or high-certainty evidence) or “conditional” (benefits and risks are closely balanced, or only low-certainty evidence or no d...

2020 American College of Rheumatology Guideline for the Management of Gout.
https://doi.org/10.1002/art.41247
Arthritis & Rheumatology (Hoboken, N.J.) References; FitzGerald JD, Dalbeth N et. al.

May 11th, 2020 - To provide guidance for the management of gout, including indications for and optimal use of urate-lowering therapy (ULT), treatment of gout flares, and lifestyle and other medication recommendations. Fifty-seven population, intervention, comparat...

Rising Incidence of Acute Hospital Admissions due to Gout
http://www.jrheum.org/content/47/4/619.long
The Journal of Rheumatology; Russell MD

Mar 31st, 2020 - To describe trends in acute hospital admissions due to gout in England, with rheumatoid arthritis (RA) as a comparator, alongside prescribing trends for common gout medications.

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
https://www.nejm.org/doi/full/10.1056/NEJMoa1912388?query=featured_home
New England Journal of Medicine; Tardif JC et al

Nov 16th, 2019 - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis.

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Drugs  563 results see all →

Clinicaltrials.gov  7,989 results

Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone.
https://doi.org/10.1124/molpharm.120.000086
Molecular Pharmacology; Tang LWT, Verma RK et. al.

Jan 13th, 2021 - Benzbromarone (BBR), a potent uricosuric agent for the management of gout, is known to cause fatal fulminant hepatitis. While the mechanism of BBR-induced idiosyncratic hepatotoxicity remains unelucidated, cytochrome P450 enzyme (CYP450)-mediated ...

Naproxen - naproxen tablet-A-S Medication Solutions
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d06db628-f6f0-48e2-b538-69c0837c49e3

Jan 13th, 2021 - Naproxen tablets and naproxen sodium tablets are indicated for: the relief of the signs and symptoms of: •rheumatoid arthritis •osteoarthritis •ankylosing spondylitis •Polyarticular Juvenile Idiopathic Arthritis Naproxen tablets and naproxen sodiu...

Colchicine - colchicine tablet, film coated-RedPharm Drug, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96ca32da-68cc-d757-e053-2995a90a76d8

Jan 13th, 2021 - Colchicine Tablets, USP are indicated for prophylaxis and the treatment of acute gout flares. Prophylaxis of Gout Flares: Colchicine Tablets, USP are indicated for prophylaxis of gout flares. Treatment of Gout Flares: Colchicine Tablets, USP are i...

Naproxen - naproxen tablet-REMEDYREPACK INC.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=88a548d1-97c0-46d0-825a-75ef689d6470

Jan 13th, 2021 - Naproxen tablets and naproxen sodium tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen tablets and naproxen sodium ta...

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News  1,217 results

Association Between Gout and Comorbidities is Independent of Serum Urate Level
https://www.medscape.com/viewarticle/943485

Jan 3rd, 2021 - Takeaway Cardiovascular comorbidities and chronic kidney disease (CKD) associate with increasing serum urate (SU) in modest (e.g. 1 mg/dl) increments.

Weight Loss May Be Paramount Lifestyle Change in Preventing Gout
https://www.medscape.com/viewarticle/943128

Dec 22nd, 2020 - A recent analysis of the incidence of gout in men, published in JAMA Network Open, offers new insights on the role of lifestyle changes in preventing gout, particularly the importance of obesity and its modification. Prior gout research, although ...

Colchicine a Case Study for What's Wrong With US Drug Pricing
https://www.medscape.com/viewarticle/941885

Dec 1st, 2020 - Public spending on colchicine has grown exponentially over the past decade despite generics suggesting an uphill slog for patients seeking access to long-term therapy for gout or cardiac conditions. Medicaid spending on single-ingredient colchicin...

Gout Clinical Practice Guidelines (ACR, 2020)
https://reference.medscape.com/viewarticle/941449

Nov 23rd, 2020 - Guidelines for managing gout were published in June 2020 by the American College of Rheumatology (ACR).[1] Indications for Pharmacologic Urate-Lowering Therapy (ULT)   Initiating ULT is strongly recommended for gout patients with ≥1 subcutaneous t...

Comparative Performances of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Gout in Type 2 Diabetes
https://www.rheumatologyadvisor.com/home/conference-highlights/acr-convergence-2020/comparative-performance-of-sglt2-inhibitors-in-reducing-gout-in-t2d/

Nov 8th, 2020 - Among patients with type 2 diabetes (T2D), sodium-glucose cotransporter-2 (SGLT2) inhibitors dapagliflozin and empagliflozin vs canagliflozin show greater benefit in reducing gout, according to research results presented at the American College of...

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Patient Education  51 results see all →