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About 8,413 results

ALLMedicine™ Epilepsy Center

Research & Reviews  2,664 results

Evaluation and management of drug resistant epilepsy in children.
https://doi.org/10.1016/j.cppeds.2021.101035
Current Problems in Pediatric and Adolescent Health Care; Kumar G

Jul 26th, 2021 - Epilepsy is one of the most common neurological conditions in children. Most children with epilepsy respond to anti- epileptic drugs (AEDs) but approximately 30% of children develop drug resistant epilepsy (DRE) defined as 'the failure of adequate...

Brain structural changes in patients with cardio-facio-cutaneous syndrome: effects of B...
https://doi.org/10.1007/s00234-021-02769-w 10.1542/peds.2013-3189 10.1038/ng1749 10.1111/ocr.12144 10.1002/ajmg.a.36737 10.1002/1096-8628(20001113)95:2<135::AID-AJMG8>3.0.CO;2-J 10.1016/j.seizure.2011.07.013 10.1111/j.1469-8749.2007.00894.x 10.1016/j.braindev.2012.12.007 10.1002/ajmg.a.37552 10.1126/science.1124642 10.1016/j.gde.2009.04.001 10.1002/ajmg.a.33787 10.1002/ajmg.a.30834 10.3174/ajnr.A5611 10.1007/s003810050075 10.1111/j.1399-0004.1990.tb03600.x 10.1016/S0140-6736(15)60694-8 10.1097/BPO.0b013e318220396e 10.1146/annurev-neuro-070815-014023 10.1016/j.wneu.2020.06.106 10.1212/WNL.0000000000004176 10.1001/jamaneurol.2016.1572 10.1038/nrneurol.2016.98 10.1007/s12311-013-0470-2 10.1016/j.neuroimage.2006.01.015 10.1002/hbm.23139 10.1006/nimg.1998.0395 10.1016/j.neuroimage.2004.03.032 10.1016/s0896-6273(02)00569-x 10.1016/j.neuroimage.2006.01.021 10.1016/j.neuroimage.2015.02.065 10.1186/s13041-019-0517-5 10.1016/j.braindev.2010.03.008 10.1038/s10038-019-0579-3 10.1016/j.neuroimage.2006.05.038 10.1007/s10548-014-0366-6 10.1016/s0896-6273(00)80911-3 10.1016/j.braindev.2011.12.011 10.1097/01.wco.0000162860.49842.90 10.1080/00325481.2019.1663126 10.1002/jmri.22330 10.1016/s0079-6123(08)63367-1
Neuroradiology Calandrelli R, Pilato F et. al.

Jul 26th, 2021 - To evaluate the brain volumetric changes caused by BRAF gene mutation in non-epileptic CFC patients and the influence of the age of epilepsy onset on brain development in 2 cohorts of epileptic CFC patients. We enrolled CFC patients carrying BRAF ...

Patients' Explanatory Models about drug-resistant epilepsy in Argentina. A thematic ana...
https://doi.org/10.1016/j.seizure.2021.07.008
Seizure Sarudiansky M, Lanzillotti AI et. al.

Jul 25th, 2021 - The aim of this study is to explore explanatory models (EM) about epilepsy in patients with drug-resistant epilepsy (DRE) in Buenos Aires, Argentina. A qualitative approach gathered data through semi-structured interviews, oriented to gain an in-d...

Apparent diffusion coefficient is associated with seizure outcome after magnetic resona...
https://doi.org/10.1016/j.eplepsyres.2021.106726
Epilepsy Research; Kim MJ, Hwang B et. al.

Jul 23rd, 2021 - Magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) is becoming a first-line surgical therapy for mesial temporal lobe epilepsy (mTLE) due to good seizure control and low complication risk. However, seizure outcomes after MRgLiT...

PRRT2 variants and effectiveness of various antiepileptic drugs in self-limited familia...
https://doi.org/10.1016/j.seizure.2021.07.013
Seizure Zhao Q, Hu Y et. al.

Jul 23rd, 2021 - Self-limited familial infantile epilepsy (SFIE) is largely associated with variants in proline-rich transmembrane protein 2 (PRRT2). However, the detailed phenotype-genotype correlations are unclear, along with the efficacy of various antiepilepti...

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Guidelines  4 results

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic d...
https://doi.org/10.1212/WNL.0000000000005756
Neurology Kanner AM, Ashman E et. al.

Jun 14th, 2018 - To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). 2004 criteria were used to systemically review literature (January 2003 to Nove...

Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and ris...
https://doi.org/10.1212/WNL.0000000000003685
Neurology Harden C, Tomson T et. al.

Apr 25th, 2017 - To determine the incidence rates of sudden unexpected death in epilepsy (SUDEP) in different epilepsy populations and address the question of whether risk factors for SUDEP have been identified. Systematic review of evidence; modified Grading Reco...

Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review)...
https://doi.org/10.1111/j.1528-1167.2009.02129.x
Epilepsia Harden CL, Meador KJ et. al.

Jun 9th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including antiepileptic drug (AED) teratogenicity and adverse perinatal outcomes. It is hig...

Management issues for women with epilepsy--focus on pregnancy (an evidence-based review...
https://doi.org/10.1111/j.1528-1167.2009.02130.x
Epilepsia Harden CL, Pennell PB et. al.

Jun 9th, 2009 - A committee assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implicatio...

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Drugs  403 results see all →

Clinicaltrials.gov  129 results

Surgery as a Treatment for Medically Intractable Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01273129

May 7th, 2020 - Objective This protocol is being performed provide standard care therapy for patients with drug resistant epilepsy and to follow the therapeutic course of patients from pre-operative evaluation, through surgery, and post-operatively, and to collec...

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT02531880

May 6th, 2020 - Objective: The primary goals of this pilot study is to (1) describe the safety profile of administration of mangafodipir in patients with epilepsy and (2) determine if peri-ictal administration will allow focal entry of mangafodipir through the bl...

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03370120

May 4th, 2020 - The purpose of the study is to evaluate the long-term safety and tolerability of Padsevonil administered at individualized doses as adjunctive treatment for subjects with drug-resistant epilepsy.

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
https://clinicaltrials.gov/ct2/show/NCT03373383

May 4th, 2020 - The purpose of the study is to characterize the dose-response relationship with respect to efficacy of Padsevonil administered concomitantly with up to 3 anti-epileptic drugs (AEDs) for treatment of observable focal-onset seizures in subjects with...

Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy
https://clinicaltrials.gov/ct2/show/NCT01364597

Apr 23rd, 2020 - This is a Phase 3, open-label, single-arm, multicenter, long-term study to evaluate the safety and efficacy of brivaracetam (BRV) in children with epilepsy. This study was initially designed for pediatric subjects who had completed a previous BRV ...

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News  153 results

Epilepsy Linked to Anxiety, Suicidality in Young Adults
https://www.medscape.com/viewarticle/951815

May 24th, 2021 - Young adults with epilepsy experience higher rates of anxiety, depression, and suicidality, compared with their counterparts in the general population, a new study shows. The findings, based on a study of 144 young adults with epilepsy (YAWE), was...

Deeper Sleep, Slower Heart Rate Tied to Sudden Death in Epilepsy
https://www.medscape.com/viewarticle/951137

May 13th, 2021 - Deeper sleep and slower heart rate following seizures may work synergistically to increase the risk for sudden unexpected death in epilepsy (SUDEP), new research suggests. Investigators analyzed data on 100 seizures in 42 patients with epilepsy. T...

Task Force Tackles FDA Lamotrigine Cardiac Risk Warning
https://www.medscape.com/viewarticle/946270

Feb 21st, 2021 - A joint task force of the American Epilepsy Society (AES) and International League Against Epilepsy (ILAE) has issued an advisory to address concerns arising from a Food and Drug Administration (FDA) warning of cardiac risk in patients taking the ...

COVID-19's Global Impact on Epilepsy
https://www.medscape.com/viewarticle/943001

Dec 20th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Around the globe, the COVID-19 pandemic has placed an enormous strain on patients with epilepsy, new research shows. The pandemic also appears to ...

SUDEP May Explain 3% of All Sudden Deaths in Kids
https://www.medscape.com/viewarticle/942139

Dec 6th, 2020 - Sudden unexpected death in epilepsy (SUDEP) may explain 3% of all sudden deaths in children – a prevalence rate that is at least three times greater than previously reported estimates – new research shows Dr Vicky Whittemore Just a few years ago, ...

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Patient Education  12 results see all →