ALLMedicine™ Seizures Center

Mar 28th, 2023 - Structural brain lesions are the most common cause of adult-onset epilepsy. The lesion location may contribute to the risk for epileptogenesis, but whether specific lesion locations are associated with a risk for secondary seizure generalization f...

Mar 28th, 2023 - Ictal piloerection (IP) is an uncommon symptom in focal epilepsy and is associated with autoimmune encephalitis (AE). However, the networks involved in AE-associated IP are still unclear. To have a better understanding of IP underlying mechanisms,...

Mar 27th, 2023 - To study the neurophysiology of motor responses elicited by electrical stimulation of the primary motor cortex. We studied motor responses in four patients undergoing invasive epilepsy monitoring and functional cortical mapping via electrical cort...

Mar 27th, 2023 - Phelan-McDermid syndrome (PMS) is a 22q13.3 deletion syndrome that presents with a disturbed development, neurological and psychiatric characteristics, and sometimes other comorbidities like seizures. The epilepsy manifests itself in a variety of ...

Mar 27th, 2023 - We review here the neuronal mechanisms that cause seizures in focal epileptic disorders and, specifically, those involving limbic structures that are known to be implicated in human mesial temporal lobe epilepsy. In both epileptic patients and ani...

Dec 14th, 2021 - The objective of this clinical practice guideline is to provide recommendations on the indications and minimum standards for inpatient long-term video-electroencephalographic monitoring (LTVEM). The Working Group of the International League Agains...

May 8th, 2021 - In children, seizures represent an extremely heterogeneous group of medical conditions ranging from benign cases, such as a simple febrile seizure, to life-threatening situations, such as status epilepticus. Underlying causes of seizures also repr...

Nov 28th, 2020 - This article is based on a consensus conference, promoted and supported by the International Federation of Clinical Neurophysiology (IFCN), which took place in Siena (Italy) in October 2018. The meeting intended to update the ten-year-old safety g...

May 7th, 2020 - Stroke is an uncommon but an important and under-recognized cause of morbidity and mortality in children. Strokes may be due to either brain ischemia or intracranial hemorrhage. Common symptoms of pediatric acute stroke include headache, vomiting,...

May 7th, 2020 - Seizures and epilepsy are a set of conditions that can be challenging to diagnose, treat, and manage. This document summarizes recommendations for imaging in different clinical scenarios for a patient presenting with seizures and epilepsy. MRI of ...

Mar 22nd, 2023 - This study will first use multimodal imaging in abstinent subjects with HUD to determine the neural circuits associated with the effects of CBD on craving and anxiety. Secondly, the investigators will conduct 1H MRS to characterize in-vivo neuroch...

Mar 22nd, 2023 - This is a global, multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of EPX-100 as adjunctive therapy in children and adult participants with Dravet Syndrome. The study consists of a 4-week observat...

Mar 21st, 2023 - The purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.

Mar 21st, 2023 - The purpose of this proof-of-concept study is to evaluate ganaxolone as adjunctive therapy for uncontrolled seizures in female children with PCDH19 mutations and other rare genetic epilepsies. After establishing baseline seizure frequency, qualify...

Mar 21st, 2023 - Helicobacter pylori (H. pylori) is a spiral-shaped Gram-negative bacterium, which causes chronic infection in more than 50% of human population. H. pylori infection is associated with several gastrointestinal disorders, such as gastritis and gastr...

Mar 20th, 2023 - The history and findings in this case are suggestive of non–small cell lung cancer (NSCLC) large cell carcinoma. Lung cancer is the most common cancer worldwide and has the highest mortality rate of all cancers.

Mar 13th, 2023 - The FDA approved trofinetide (Daybue), the first drug to treat adult and pediatric patients age 2 and older with Rett syndrome, drugmaker Acadia Pharmaceuticals announced Friday. "Now, for the first time after decades of clinical research, healthc...

Mar 7th, 2023 - Much of the work of the Advisory Committee on Immunization Practices (ACIP) in 2022 was devoted to vaccines to protect against coronavirus disease 2019 (COVID-19); details about the 4 available products can be found on the Centers for Disease Cont.

Mar 1st, 2023 - A dual antibiotic combination was better than either drug alone for treatment of severe scrub typhus, the randomized INTREST trial showed. For patients with this tropical mite-borne bacterial illness, intravenous doxycycline and azithromycin reduc...

Mar 1st, 2023 - Psychogenic nonepileptic seizures (PNES) are a physical manifestation of a psychological disturbance. They are characterized by episodes of altered subjective experience and movements that can resemble epilepsy, syncope, or other paroxysmal disord.