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About 4,718 results

ALLMedicine™ Nasal Polyps Center

Research & Reviews  1,582 results

Dupilumab moves forward as possible COPD treatment
https://www.mdedge.com/chestphysician/article/262062/copd/dupilumab-moves-forward-possible-copd-treatment
Heidi Splete, MDedge News

Mar 28th, 2023 - Dupilumab, a fully human monoclonal antibody, significantly improved quality of life and respiratory symptoms compared with placebo in a phase 3 trial of more than 900 adults with uncontrolled chronic obstructive pulmonary disease. In the study, k.

The Burden of Migraine on Quality of Life in Chronic Rhinosinusitis.
https://doi.org/10.1002/lary.30662
The Laryngoscope; Derbarsegian A, Adams SM et. al.

Mar 28th, 2023 - To determine the impact of comorbid migraine on quality of life (QOL) in chronic rhinosinusitis (CRS). A total of 213 adult patients with CRS were recruited. All participants completed the 22-item Sinonasal Outcome Test (SNOT-22), from which total...

Evaluation of the clinical features and laboratory data of patients with severe asthma ...
https://doi.org/10.1080/02770903.2023.2196562
The Journal of Asthma : Official Journal of the Associati... Cakmak ME, Öztop N et. al.

Mar 28th, 2023 - IntroductionOmalizumab is used for the treatment of severe allergic asthma.ObjectiveThe aim of this study was to evaluate the clinical features and laboratory data of patients with severe allergic asthma classified as super-responder or non super-...

Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinus...
https://doi.org/10.1016/j.intimp.2023.110054
International Immunopharmacology; Zhang M, Xiong Y et. al.

Mar 25th, 2023 - Hypoxia is involved in inflammation and immune response; however, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) is not fully understood. We aimed to investigate the mechanisms by which hypoxia disrupts the nasal...

Dupilumab for chronic rhinosinusitis with nasal polyps: real-life retrospective 12-mont...
https://doi.org/10.4193/Rhin22.469
Rhinology Böscke R, Heidemann M et. al.

Mar 23rd, 2023 - Dupilumab, an IL-4/13 receptor inhibitor, is approved for the treatment of uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). We evaluated the effectiveness and safety of dupilumab for CRSwNP based on retrospective 12-month follow-up ...

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Guidelines  5 results

2022 American College of Rheumatology/European Alliance of Associations for Rheumatolog...
https://doi.org/10.1002/art.41982
Arthritis & Rheumatology (Hoboken, N.J.); Grayson PC, Ponte C et. al.

Feb 3rd, 2022 - To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA). Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) iden...

British Rhinological Society Consensus Guidance on the use of biological therapies for ...
https://doi.org/10.1111/coa.13779
Clinical Otolaryngology : Official Journal of ENT-UK ; Of... Hopkins C, McKenzie JL et. al.

Apr 6th, 2021 - We set out to create Consensus Guidelines, based on current evidence and relative risks of adverse effects and the costs of different treatments, which reflect the views of the British Rhinological Society (BRS) Council on where the use of biologi...

Considerations on biologicals for patients with allergic disease in times of the COVID-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300800
Allergy Vultaggio A, Agache I et. al.

Jun 6th, 2020 - The outbreak of the SARS-CoV-2-induced coronavirus disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex pat...

European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
https://doi.org/10.4193/Rhin20.600
Rhinology Fokkens WJ, Lund VJ et. al.

Feb 23rd, 2020 - The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and cle...

Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI posit...
https://doi.org/10.1111/all.13599
Allergy Kowalski ML, Agache I et. al.

Sep 15th, 2018 - NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated b...

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Drugs  25 results see all →

Clinicaltrials.gov  144 results

A Study to Evaluate CBP-201 in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps
https://clinicaltrials.gov/ct2/show/NCT04783389

Mar 21st, 2023 - This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of CBP-201 on a background of mometasone furoate nasal spray (MFNS) in reducing endoscopic nasal polyp score (NPS) and nasal congestion/obstruction sc...

Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)
https://clinicaltrials.gov/ct2/show/NCT04157335

Mar 20th, 2023 - Approximately 275 patients will be randomized to receive benralizumab 30 mg SC or matching placebo. After enrolment, eligible patients will enter a 6-week screening/run in period. Patients who meet eligibility criteria will be randomised 1:1 at We...

CST1 Predictive Model of Oral Glucocorticoid Therapy Sensitivity for Chronic Rhinosinusitis With Polyps
https://clinicaltrials.gov/ct2/show/NCT05598424

Mar 10th, 2023 - Topical and systemic steroids constitute the first choice in medical treatment for nasal polyps. Glucocorticoids sensitivity is significantly correlated with CST1 level in nasal secretions. The goal of this single-arm clinical trial based on a mul...

Impact of Symbiofilm On Nasal Microbiota
https://clinicaltrials.gov/ct2/show/NCT05015530

Mar 8th, 2023 - Chronic rhinosinusitis (CRS) is an inflammation of the nose and paranasal sinuses and is characterized by two or more symptoms, one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip),...

Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps
https://clinicaltrials.gov/ct2/show/NCT03960580

Mar 3rd, 2023 - The primary objective of this study is to compare the efficacy of intranasal administration of twice-daily doses of 186 and 372 µg of OPN-375 (fluticasone propionate) with placebo in subjects with chronic rhinosinusitis using the following co-prim...

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News  107 results

Dupilumab moves forward as possible COPD treatment
https://www.mdedge.com/chestphysician/article/262062/copd/dupilumab-moves-forward-possible-copd-treatment
Heidi Splete, MDedge News

Mar 28th, 2023 - Dupilumab, a fully human monoclonal antibody, significantly improved quality of life and respiratory symptoms compared with placebo in a phase 3 trial of more than 900 adults with uncontrolled chronic obstructive pulmonary disease. In the study, k.

History of nonproductive cough
https://www.mdedge.com/severe-asthma-challenge-center/article/260715/severe-asthma/history-nonproductive-cough

Mar 10th, 2023 - The history and findings in this case are suggestive of eosinophilic asthma. Asthma is a common, chronic, and heterogeneous respiratory disease, most often characterized by chronic airway inflammation.

Fast Five Quiz: Sinus Conditions
https://www.medscape.com/viewarticle/982466

Oct 24th, 2022 - Sinus symptoms are frequently reported among patients. Causes include nasal polyps (the most common tumors of the nasal cavity) and chronic rhinosinusitis (CRS) (one of the most common chronic medical conditions in the world). These and other sinu...

Sinusitis Experts Chart Narrow Path for Steroid-Eluting Implants
https://www.medscape.com/viewarticle/977128

Jul 13th, 2022 - Steroid-eluting implants inserted during or after sinus surgery may benefit patients with chronic sinusitis with or without nasal polyps, including those who can't tolerate oral steroids, a consensus study reports. Absorbable steroid-eluting sinus...

COVID Olfactory Trial Hints at Possible Benefit
https://www.medpagetoday.com/neurology/longcovid/99619

Jul 7th, 2022 - Theophylline added to saline nasal irrigation showed a hint of promise in treating postviral olfactory dysfunction related to COVID-19, data from the phase II SCENT2 trial suggested. In a study of 51 people with persistent olfactory dysfunction af...

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Patient Education  24 results see all →