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About 13,986 results

ALLMedicine™ Purpura Center

Research & Reviews  6,725 results

Periorbital purpura of AL amyloidosis.
https://doi.org/10.1093/rheumatology/keaa545
Rheumatology (Oxford, England); Chen-Xu M, Achilleos K

Sep 18th, 2020 - Periorbital purpura of AL amyloidosis.|2020|Chen-Xu M,Achilleos K,|

Kasabach-Merritt phenomenon with cellulitis in infant.
https://doi.org/10.1136/bcr-2020-235065
BMJ Case Reports; Yosi A, Siregar AA et. al.

Sep 16th, 2020 - Kasabach-Merritt phenomenon (KMP) is consumptive coagulopathy in large vascular lesion. This condition is specific in kaposiform haemangioendothelioma (KHE) and tufted angioma, associated with high mortality rate. This condition often involves the...

Severe thrombocytopaenia secondary to COVID-19.
https://doi.org/10.1136/bcr-2020-237645
BMJ Case Reports; Patel T, Stanton N et. al.

Sep 16th, 2020 - The SARS-CoV-2 infection has caused a pandemic with a case rate of over 290 000 lab-confirmed cases and over 40 000 deaths in the UK. There is little evidence to inform the optimal management of a patient presenting with new or relapsed acute idio...

Seasonal variations in hematological disorders: A 10-year single-center experience.
https://doi.org/10.1111/ijlh.13337
International Journal of Laboratory Hematology REFERENCES; Hassan J, Adil SO et. al.

Sep 15th, 2020 - To assess the seasonal variations in hematological disorders among patients diagnosed on the basis of bone marrow biopsy, who attended National Institute of Blood Diseases (NIBD) clinics during 2006 to 2015. We retrospectively reviewed the 10-year...

Frequent recurrence of pregnancy-triggered congenital thrombotic thrombocytopenic purpu...
https://doi.org/10.3233/CH-200970
Clinical Hemorheology and Microcirculation; Xu J, Yu S et. al.

Sep 14th, 2020 - Thrombotic thrombocytopenic purpura (TTP) in adults is rare thrombotic microangiopathy (TMA), which is closely related to the lack of specific proteases of von Willebrand factor (vWF) multimers. It is currently believed that both congenital TTP (c...

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Guidelines  17 results

European consensus-based recommendations for diagnosis and treatment of immunoglobulin ...
https://doi.org/10.1093/rheumatology/kez041
Rheumatology (Oxford, England); Ozen S, Marks SD et. al.

Mar 17th, 2019 - IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatm...

CABLIVI (caplacizumab-yhdp) Prescribing Information
http://products.sanofi.us/cablivi/cablivi.pdf

Feb 5th, 2019 - CABLIVI is a von Willebrand factor (vWF)-directed antibody fragment indicated for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

FDA approves Cablivi, first treatment for acquired thrombotic thrombocytopenic purpura
https://www.healio.com/hematology-oncology/hematology/news/online/%7Be91d83f6-8859-412b-970c-198151f0b208%7D/fda-approves-cablivi-first-treatment-for-acquired-thrombotic-thrombocytopenic-purpura
Pazdur,R.

Feb 5th, 2019 - The FDA today approved caplacizumab-yhdp injection as the first therapy specifically indicated for the treatment of adults with acquired thrombotic thrombocytopenic purpura, a rare and life-threatening blood clotting disorder.

FDA approves Cablivi® (caplacizumab-yhdp), the first Nanobody®-based medicine, for adults with acquired thrombotic thrombocytopenic purpura (aTTP)
http://hugin.info/152918/R/2233733/878824.pdf

Feb 5th, 2019 - The U.S. Food and Drug Administration (FDA) has approved Cablivi® (caplacizumab-yhdp) in combination with plasma exchange and immunosuppression for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults. Cablivi is the firs...

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
https://www.nejm.org/doi/10.1056/NEJMoa1806311
Scully,M.,et al

Jan 23rd, 2019 - In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which re...

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Drugs  51 results see all →

Clinicaltrials.gov  6,869 results

Periorbital purpura of AL amyloidosis.
https://doi.org/10.1093/rheumatology/keaa545
Rheumatology (Oxford, England); Chen-Xu M, Achilleos K

Sep 18th, 2020 - Periorbital purpura of AL amyloidosis.|2020|Chen-Xu M,Achilleos K,|

Kasabach-Merritt phenomenon with cellulitis in infant.
https://doi.org/10.1136/bcr-2020-235065
BMJ Case Reports; Yosi A, Siregar AA et. al.

Sep 16th, 2020 - Kasabach-Merritt phenomenon (KMP) is consumptive coagulopathy in large vascular lesion. This condition is specific in kaposiform haemangioendothelioma (KHE) and tufted angioma, associated with high mortality rate. This condition often involves the...

Severe thrombocytopaenia secondary to COVID-19.
https://doi.org/10.1136/bcr-2020-237645
BMJ Case Reports; Patel T, Stanton N et. al.

Sep 16th, 2020 - The SARS-CoV-2 infection has caused a pandemic with a case rate of over 290 000 lab-confirmed cases and over 40 000 deaths in the UK. There is little evidence to inform the optimal management of a patient presenting with new or relapsed acute idio...

Seasonal variations in hematological disorders: A 10-year single-center experience.
https://doi.org/10.1111/ijlh.13337
International Journal of Laboratory Hematology REFERENCES; Hassan J, Adil SO et. al.

Sep 15th, 2020 - To assess the seasonal variations in hematological disorders among patients diagnosed on the basis of bone marrow biopsy, who attended National Institute of Blood Diseases (NIBD) clinics during 2006 to 2015. We retrospectively reviewed the 10-year...

Frequent recurrence of pregnancy-triggered congenital thrombotic thrombocytopenic purpu...
https://doi.org/10.3233/CH-200970
Clinical Hemorheology and Microcirculation; Xu J, Yu S et. al.

Sep 14th, 2020 - Thrombotic thrombocytopenic purpura (TTP) in adults is rare thrombotic microangiopathy (TMA), which is closely related to the lack of specific proteases of von Willebrand factor (vWF) multimers. It is currently believed that both congenital TTP (c...

see more →

News  293 results

Pediatric Dermatology Emergencies
https://www.mdedge.com/dermatology/article/218463/pediatrics/pediatric-dermatology-emergencies/page/0/3?channel=271

Mar 5th, 2020 - IgA Vasculitis Presentation IgA vasculitis, or Henoch-Schönlein purpura, classically presents as a tetrad of palpable purpura, acute-onset arthritis or arthralgia, abdominal pain, and renal disease with proteinuria or hematuria. 30 Skin involvement.

Rash on legs and abdomen
https://www.mdedge.com/familymedicine/article/215177/dermatology/rash-legs-and-abdomen?channel=114
MDedge Family Medicine;

Jan 16th, 2020 - The rash was consistent with nonblanching purpura. Two punch biopsies were performed for hematoxylin and eosin stain and direct immunofluorescence, which were consistent with IgA mediated small vessel vasculitis, or Henoch-Schoenlein purpura.

2019 at a glance: Hem-onc U.S. drug approvals
https://www.mdedge.com/jcomjournal/article/211340/mixed-topics/2019-glance-hem-onc-us-drug-approvals/page/0/1?channel=325

Oct 31st, 2019 - Caplacizumab-yhdp (Cablivi) Class: Monoclonal antibody fragment directed against von Willebrand factor. Disease: Thrombotic thrombocytopenic purpura.

ISTH releases draft guideline for TTP diagnosis, treatment
https://www.mdedge.com/hematology-oncology/article/210491/bleeding-disorders/isth-releases-draft-guideline-ttp-diagnosis?channel=39313
Will Pass

Oct 21st, 2019 - A new draft guideline for the diagnosis and management of thrombocytopenic purpura (TTP) was recently released by the International Society on Thrombosis and Hemostasis (ISTH). Svisio/Thinkstock According to the panel of experts involved, the ISTH.

In older patients with immune-mediated TTP, atypical features may delay diagnosis
https://www.mdedge.com/hematology-oncology/article/209753/bleeding-disorders/older-patients-immune-mediated-ttp-atypical?channel=39313
Andrew D. Bowser

Oct 9th, 2019 - Older patients with immune thrombotic thrombocytopenic purpura (iTTP) more often have an atypical neurological presentation, which could result in a delayed diagnosis, according to authors of a recent retrospective analysis. “Practitioners should.

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Patient Education  31 results see all →