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About 14,680 results

ALLMedicine™ Purpura Center

Research & Reviews  7,011 results

A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates ...
https://doi.org/10.1111/jth.15332
Journal of Thrombosis and Haemostasis : JTH; Halkidis K, Siegel DL et. al.

Apr 9th, 2021 - Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS13 activity. Immunoglobulin (Ig) G-type autoantibodies are primarily responsible for the inhibi...

Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome With Severe Thromboc...
https://doi.org/10.1097/AOG.0000000000004345 10.1182/asheducation-2015.1.644 10.1016/j.emc.2014.04.008 10.1111/bjh.13654 10.1186/1471-2393-9-8 10.1046/j.1365-2141.2003.04049.x 10.1002/jca.10005 10.3109/14767058.2011.619603 10.1111/jog.13786 10.1182/bloodadvances.2017005124 10.4137/CCRep.S12122 10.1111/jth.12221 10.1182/blood-2005-01-0152 10.1016/j.thromres.2020.09.012
Obstetrics and Gynecology; Wade AN, Panchmatia R et. al.

Apr 8th, 2021 - Differentiating preeclampsia with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome from thrombotic thrombocytopenic purpura (TTP) can present a diagnostic dilemma. We report the case of a 34-year-old woman, G1P0, with mon...

Acute kidney injury and nephrotic syndrome associated with eltrombopag therapy in chron...
https://doi.org/10.1136/bcr-2020-241462
BMJ Case Reports; Ghosh SA, Patrick J et. al.

Apr 8th, 2021 - A 77-year-old man was admitted with severe acute kidney injury and nephrotic syndrome. He was started on eltrombopag for chronic idiopathic thrombocytopenic purpura 6 weeks earlier. An ultrasound of the kidneys was normal and an auto-antibody scre...

Neonatal systemic juvenile Xanthogranuloma with Hydrops diagnosed by Purpura skin biops...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022363
BMC Pediatrics; Uehara Y, Wada YS et. al.

Apr 7th, 2021 - Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xanthogranuloma with atypical skin appeara...

Spontaneous bilateral peri-orbital purpura: an important clinical sign of primary syste...
https://doi.org/10.1136/bcr-2020-239478
BMJ Case Reports; Beatty PE, Killion L et. al.

Apr 2nd, 2021 - A 69-year-old woman presented with an 18-month history of recurrent bruising of the eyelids. She was otherwise asymptomatic and systems review was unremarkable. On examination, she had peri-orbital purpura and waxy papules at the inner canthus of ...

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Guidelines  19 results

Oropharyngeal psychogenic purpura.
https://doi.org/10.1111/bjh.17021
British Journal of Haematology; Allar BG, Michaelsen K et. al.

Aug 5th, 2020 - Oropharyngeal psychogenic purpura.|2020|Allar BG,Michaelsen K,Gupta A,Bose S,|metabolism,pathology,metabolism,pathology,metabolism,pathology,metabolism,pathology,metabolism,pathology,

European consensus-based recommendations for diagnosis and treatment of immunoglobulin ...
https://doi.org/10.1093/rheumatology/kez041
Rheumatology (Oxford, England); Ozen S, Marks SD et. al.

Mar 17th, 2019 - IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatm...

CABLIVI (caplacizumab-yhdp) Prescribing Information
http://products.sanofi.us/cablivi/cablivi.pdf

Feb 5th, 2019 - CABLIVI is a von Willebrand factor (vWF)-directed antibody fragment indicated for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy.

FDA approves Cablivi, first treatment for acquired thrombotic thrombocytopenic purpura
https://www.healio.com/hematology-oncology/hematology/news/online/%7Be91d83f6-8859-412b-970c-198151f0b208%7D/fda-approves-cablivi-first-treatment-for-acquired-thrombotic-thrombocytopenic-purpura
Pazdur,R.

Feb 5th, 2019 - The FDA today approved caplacizumab-yhdp injection as the first therapy specifically indicated for the treatment of adults with acquired thrombotic thrombocytopenic purpura, a rare and life-threatening blood clotting disorder.

FDA approves Cablivi® (caplacizumab-yhdp), the first Nanobody®-based medicine, for adults with acquired thrombotic thrombocytopenic purpura (aTTP)
http://hugin.info/152918/R/2233733/878824.pdf

Feb 5th, 2019 - The U.S. Food and Drug Administration (FDA) has approved Cablivi® (caplacizumab-yhdp) in combination with plasma exchange and immunosuppression for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults. Cablivi is the firs...

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Drugs  59 results see all →

Clinicaltrials.gov  7,215 results

A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates ...
https://doi.org/10.1111/jth.15332
Journal of Thrombosis and Haemostasis : JTH; Halkidis K, Siegel DL et. al.

Apr 9th, 2021 - Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS13 activity. Immunoglobulin (Ig) G-type autoantibodies are primarily responsible for the inhibi...

Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome With Severe Thromboc...
https://doi.org/10.1097/AOG.0000000000004345 10.1182/asheducation-2015.1.644 10.1016/j.emc.2014.04.008 10.1111/bjh.13654 10.1186/1471-2393-9-8 10.1046/j.1365-2141.2003.04049.x 10.1002/jca.10005 10.3109/14767058.2011.619603 10.1111/jog.13786 10.1182/bloodadvances.2017005124 10.4137/CCRep.S12122 10.1111/jth.12221 10.1182/blood-2005-01-0152 10.1016/j.thromres.2020.09.012
Obstetrics and Gynecology; Wade AN, Panchmatia R et. al.

Apr 8th, 2021 - Differentiating preeclampsia with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome from thrombotic thrombocytopenic purpura (TTP) can present a diagnostic dilemma. We report the case of a 34-year-old woman, G1P0, with mon...

Acute kidney injury and nephrotic syndrome associated with eltrombopag therapy in chron...
https://doi.org/10.1136/bcr-2020-241462
BMJ Case Reports; Ghosh SA, Patrick J et. al.

Apr 8th, 2021 - A 77-year-old man was admitted with severe acute kidney injury and nephrotic syndrome. He was started on eltrombopag for chronic idiopathic thrombocytopenic purpura 6 weeks earlier. An ultrasound of the kidneys was normal and an auto-antibody scre...

Neonatal systemic juvenile Xanthogranuloma with Hydrops diagnosed by Purpura skin biops...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022363
BMC Pediatrics; Uehara Y, Wada YS et. al.

Apr 7th, 2021 - Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xanthogranuloma with atypical skin appeara...

Spontaneous bilateral peri-orbital purpura: an important clinical sign of primary syste...
https://doi.org/10.1136/bcr-2020-239478
BMJ Case Reports; Beatty PE, Killion L et. al.

Apr 2nd, 2021 - A 69-year-old woman presented with an 18-month history of recurrent bruising of the eyelids. She was otherwise asymptomatic and systems review was unremarkable. On examination, she had peri-orbital purpura and waxy papules at the inner canthus of ...

see more →

News  351 results

Low Threshold to Biopsy Atypical Lesions May ID Vulvar Melanoma Early, Experts Say
https://www.staging.medscape.com/viewarticle/941157

Nov 16th, 2020 - Having a low threshold to biopsy atypical pigmented lesions on the vulva may identify melanoma early, according to a lecture at virtual conference on diseases of the vulva and vagina, hosted by the International Society for the Study of Vulvovagin...

Low Threshold to Biopsy Atypical Lesions May ID Vulvar Melanoma Early, Experts Say
https://www.medscape.com/viewarticle/941157

Nov 16th, 2020 - Having a low threshold to biopsy atypical pigmented lesions on the vulva may identify melanoma early, according to a lecture at virtual conference on diseases of the vulva and vagina, hosted by the International Society for the Study of Vulvovagin...

NICE Recommends Innovative Treatment for Severe Blood Disorder for NHS Use
https://www.medscape.com/viewarticle/941022

Nov 15th, 2020 - A brand-new treatment – one of the first for 25 years – for acute acquired thrombotic thrombocytopenic purpura (aTTP) has been recommended by the National Institute for Health and Care Excellence (NICE) for routine use in the NHS. Caplacizumab (Ca...

Skin Symptoms Common in COVID 'Long-Haulers'
https://www.staging.medscape.com/viewarticle/940058

Oct 29th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A small subset of SARS-CoV-2 patients with "COVID toes" can be categorized as COVID long-haulers, with skin symptoms sometimes enduring for more t...

Skin Symptoms Common in COVID 'Long-Haulers'
https://www.medscape.com/viewarticle/940058

Oct 29th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A small subset of SARS-CoV-2 patients with "COVID toes" can be categorized as COVID long-haulers, with skin symptoms sometimes enduring for more t...

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Patient Education  25 results see all →