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About 2,595,744 results
Bleomycin - bleomycin injection, powder, lyophilized, for solution-Amneal Pharmaceuticals LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=38955939-8d1e-4db2-9aed-3bab72ca5f8f

Dec 26th, 2020 - Palliation and treatment adjutant to surgery and radiation therapy of the following neoplasms: Squamous cell carcinoma of the skin, head and neck, and esophagus (primary indication). Squamous cell carcinoma of the larynx, penis and uterine cervix. Squamous cell carcinoma of the bronchus (response infrequent). Ch0riocarcinoma and embryonal cell carcinoma of the testis. Advanced Hodgkin’s disease...

Comprehensive Profiling of Zika Virus Risk with Natural and Artificial Mitigating Strat...
https://doi.org/10.3201/eid2604.181739
Emerging Infectious Diseases; Mina MJ, Guterman LB et. al.

Apr 16th, 2020 - Zika virus is transitioning to become a long-term public health challenge, and countries should remain informed of the risk for emergence. We developed a stochastic epidemiologic model to profile risk for Zika virus emergence, including trimester-specific fetal risk across time, in all 3,208 counties in the United States, including Puerto Rico. Validation against known transmission in North Ame...

Oxycodone hydrochloride and acetaminophen - oxycodone hydrochloride and acetaminophen solution-Mikart, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=483e7cd1-5d70-4d83-8846-df791f73a97a

Feb 29th, 2020 - Oxycodone hydrochloride and acetaminophen oral solution is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse, with opioids, even at recommended doses [see WARNINGS ], reserve oxycodone hydrochloride and acetaminophen oral solution for use i...

Non-Invasive Sensor Predicts Heart-Failure Rehospitalization
https://www.medscape.com/viewarticle/925753

Feb 27th, 2020 - NEW YORK (Reuters Health) - A wearable sensor can predict rehospitalization in heart failure (HF) patients with an accuracy similar to that of implanted sensors, new research shows. "The clinical efficacy and generalizability of this low-cost noninvasive approach to rehospitalization mitigation should be further tested," Dr. Josef Stehlik of VA Salt Lake City Health Care System and colleagues c...

As Wildfires Worsen, Firefighters Go High-Tech to Stay Healthy
https://www.medscape.com/viewarticle/925780

Feb 27th, 2020 - OLIVELLA, Spain (Thomson Reuters Foundation) - As flames and smoke from burning bushes billowed towards them, Catalan firefighters calmly controlled the progress of a planned fire on a forested hillside - an exercise aimed at reducing the danger of blazes breaking out later in the summer heat. Prescribed forest burns like this, which thin out flammable undergrowth, are a well-known way of lower...

Predicting success in an undergraduate exercise science program using science-based adm...
https://doi.org/10.1152/advan.00130.2019
Advances in Physiology Education; Esmat TA, Pitts JD

Feb 27th, 2020 - Student success is an important focus within higher education as it relates to retention, progression, and graduation rates. Limited research exists examining the predictors of success within an undergraduate Exercise Science program. The purpose of this investigation was to examine the viability of an admission policy implemented within an undergraduate Exercise Science program as a method of ...

The refinement of flipped teaching implementation to include retrieval practice.
https://doi.org/10.1152/advan.00143.2019
Advances in Physiology Education; Gopalan C, Fentem A et. al.

Feb 27th, 2020 - There has been growing evidence that flipped teaching (FT) can increase student engagement. Traditional lecture-based teaching (TT) method was compared with FT and FT combined with retrieval practice (FTR) in a 400-level Exercise Physiology course over eight semesters. In the FT format, lecture content was assigned for students to prepare before class along with an online quiz. During class, th...

Systemic and Regional Hemodynamic Response to Activation of the Exercise Pressor Reflex...
https://doi.org/10.1152/ajpheart.00493.2019
American Journal of Physiology. Heart and Circulatory Physiology; Kim DJ, Kuroki MT et. al.

Feb 27th, 2020 - Patients with peripheral arterial disease (PAD) have an accentuated exercise pressor reflex (EPR) during exercise of the affected limb. The underlying hemodynamic changes responsible for this, and its effect on blood flow to the exercising extremity is unclear. We tested the hypothesis that the exaggerated EPR in PAD is mediated by an increase in total peripheral resistance (TPR), which augment...

Heart Failure in Single Right Ventricle Congenital Heart Disease: Physiologic and Molec...
https://doi.org/10.1152/ajpheart.00518.2019
American Journal of Physiology. Heart and Circulatory Physiology; Garcia AM, Beatty JT et. al.

Feb 27th, 2020 - Due to remarkable surgical and medical advances over the past several decades, there are growing numbers of infants and children living with single ventricle congenital heart disease (SV), where there is only one functional cardiac pumping chamber. Nevertheless, cardiac dysfunction and ultimately heart failure is a common complication in the SV population and pharmacologic heart failure therapi...

Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodelin...
https://doi.org/10.1152/ajpheart.00321.2019
American Journal of Physiology. Heart and Circulatory Physiology; Kang Y, Zhang G et. al.

Feb 27th, 2020 - Right ventricular (RV) dysfunction is the main determinant of mortality in patients with pulmonary arterial hypertension (PAH) and while inflammation is pathogenic in PAH there is limited information on the role of RV inflammation in PAH. Sulforaphane (SFN), a potent Nrf2 activator, has significant anti-inflammatory effects and facilitates cardiac protection in preclinical diabetic models. Ther...

Clinical pharmacology of imeglimin for the treatment of type 2 diabetes.
https://doi.org/10.1080/14656566.2020.1729123
Expert Opinion on Pharmacotherapy; Johansson KS, Brønden A et. al.

Feb 27th, 2020 - Introduction: With the rising prevalence of type 2 diabetes (T2D), there is a substantial interest in novel, glucose-lowering drugs that may complement existing treatment options. Imeglimin is an oral antidiabetic agent currently in clinical development.Areas covered: This review is based on a literature search using PubMed and Embase including all published manuscripts and presentations concer...

Intimate Partner Violence Among Women Accessing HIV-Care Services at Tertiary Hospitals...
https://doi.org/10.1177/0886260520909189
Journal of Interpersonal Violence; Abiodun O, Sodeinde K et. al.

Feb 27th, 2020 - Intimate partner violence is both a predisposing factor for and sequelae of HIV infection. It is more likely for HIV-positive women to experience intimate partner violence compared with HIV-negative women. Previous researches have described the other risk factors for intimate partner violence. This cross-sectional study identified the correlates of intimate partner violence among HIV-positive w...

Dorsal muscle fatigue increases thoracic spine curvature in all-out recreational ergome...
https://doi.org/10.1080/17461391.2020.1737242
European Journal of Sport Science; Willwacher S, Koopmann T et. al.

Feb 27th, 2020 - The purpose of this study was to investigate fatigue-related changes in spinal kinematics, kinetics, and muscle activity of back muscles during a 2000 m all-out ergometer rowing performance. We analyzed ten male subjects with experience in both rowing and CrossFit exercises. We applied a novel kinematic method to describe spine curvature, determined bending moments at the spine using inverse dy...

What is the role of sleep in physician burnout?
https://doi.org/10.5664/jcsm.8412
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Kancherla BS, Upender R et. al.

Feb 27th, 2020 - The occurrence of physician burnout is widespread among clinicians and academic faculty, who report indicators such as low quality of life and poor work-life balance. Chronic insufficient sleep, whether due to extended work hours, circadian misalignment, or unrecognized sleep disorders, is a critically important risk factor for burnout that is overlooked and under-studied, and interventions to ...

Sleep, Fatigue and Burnout Among Physicians: An American Academy of Sleep Medicine Posi...
https://doi.org/10.5664/jcsm.8408
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine; Kancherla BS, Upender R et. al.

Feb 27th, 2020 - Physician burnout is a serious and growing threat to the medical profession and may undermine efforts to maintain a sufficient physician workforce to care for the growing and aging patient population in the U.S. Burnout involves a host of complex underlying associations and potential for risk. While prevalence is unknown, recent estimates of physician burnout are quite high, approaching 50% or ...

In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine.
https://doi.org/10.3851/IMP3348
Antiviral Therapy; Matejin S, Bukreyeva N et. al.

Feb 27th, 2020 - Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug repurposing by virtual screening of DrugBank revealed the anticholinergic drug cycrimine as a possible inhibitor of the influenza virus infection. In this study we examined the potential ...

Monocytes from men living with HIV exhibit heightened atherogenic potential despite lon...
https://doi.org/10.1097/QAD.0000000000002460
AIDS (London, England); Angelovich TA, Trevillyan JM et. al.

Feb 27th, 2020 - People living with HIV have an increased risk of cardiovascular disease (CVD) despite effective antiretroviral therapy (ART). Monocytes play a key role in the early stages of atherosclerosis-driven CVD by forming lipid-laden foam cells within artery walls. HIV infection potentiates foam cell formation ex vivo, but the mechanisms contributing to this are not known. We investigated the atheroscle...

Pattern of Hemolytic Anemia Among Egyptian Pediatric Emergency Department Patients.
https://doi.org/10.1097/PEC.0000000000002053
Pediatric Emergency Care; Badr MSEM, Afifi RAA

Feb 27th, 2020 - The emergency department is considered the backbone of the medical service offered in any hospital. Yet, the data on the frequency of pediatric hematological presentation is scanty. Anemia occurs in 9% to 14% of pediatric emergency department (ED) patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects more than 400 million people worldwide. Unfortunately, we do not have screening...

Isolated Oculomotor Nerve Palsy: A Unique Presentation of Haemophilus influenzae Type A...
https://doi.org/10.1097/PEC.0000000000002054
Pediatric Emergency Care; Latuska RF, Otillio JK

Feb 27th, 2020 - In this case report, we describe a unique case of Haemophilus influenzae type A meningitis in a 7-month-old previously healthy girl that presented with an isolated cranial nerve (oculomotor) palsy without other signs and symptoms classically associated with this entity such as fever, meningismus, or a generally ill appearance. Oculomotor nerve abnormalities are rare in pediatrics. Congenital oc...

Picornavirus Infections Are Associated with Acute Otitis Media in a Prospective Birth C...
https://doi.org/10.1093/infdis/jiaa087
The Journal of Infectious Diseases; Seppälä EM, Oikarinen S et. al.

Feb 27th, 2020 - Human rhinoviruses (HRV), enteroviruses (HEV) and parechoviruses (HPeV) have been linked to acute otitis media (AOM). We evaluated this association in a prospective birth cohort setting. 324 healthy infants were followed up from birth to the age of 3 years. Nasal swab samples were collected at the age of 3, 6, 12, 18, 24, and 36 months, and screened for HRV and HEV using real-time RT-qPCR. Stoo...