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About 148 results

ALLMedicine™ Bile Duct Strictures Center - Clinicaltrials.gov

Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatograph...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943248
Gut Singhi AD, Nikiforova MN et. al.

Apr 11th, 2019 - Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign and malignant bile duct strictures remains a diagnostic conundrum. Recent developments in next-generation sequencing (NGS) have opened new opportunities for early detection and management of cancers but, to date, have not been rigorously applied to biliary specimens. We prospectively evalua...

The economic impact of using single-operator cholangioscopy for the treatment of diffic...
https://doi.org/10.1055/s-0043-121268
Endoscopy Deprez PH, Garces Duran R et. al.

Nov 24th, 2017 - Conventional endoscopic retrograde cholangiopancreatography (ERCP) combines endoscopy and radiography to diagnose and treat pathological conditions of the bile duct. The aim of the present analysis was to evaluate the clinical and economic impact of the use of single-operator intraductal cholangioscopy (IDC), which allows for direct visualization of the bile duct, as an alternative to ERCP for ...

Biliary complications after liver transplantation; recent developments in etiology, dia...
https://doi.org/10.1016/j.bpg.2017.04.002
Best Practice & Research. Clinical Gastroenterology; Roos FJM, Poley JW et. al.

Jun 18th, 2017 - Biliary complications are considered to be the Achilles' heel of liver transplantation. The most common complications are leaks and bile duct strictures. Strictures can arise at the level of the anastomosis (anastomotic strictures; AS) or at other locations in the biliary tree (non-anastomotic strictures; NAS). Endoscopic treatment via endoscopic retrograde cholangiopancreatography (ERCP) is co...

Endoscopic ultrasound-guided fine-needle aspiration biopsy in the evaluation of bile du...
https://doi.org/10.1097/MEG.0b013e3283426313
European Journal of Gastroenterology & Hepatology; Wu LM, Jiang XX et. al.

Dec 24th, 2010 - Recently, there are very few research on endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of bile duct and gallbladder masses. The objective of this study was to assess the overall diagnostic accuracy of EUS-FNA in the evaluation of patients with bile duct strictures and gallbladder masses with a meta-analysis. The MEDLINE, EMBASE, Cancerlit and Cochrane Library, and other database...

Adult bile duct strictures: role of MR imaging and MR cholangiopancreatography in chara...
https://doi.org/10.1148/rg.343125211
Radiographics : a Review Publication of the Radiological ... Katabathina VS, Dasyam AK et. al.

May 13th, 2014 - Bile duct strictures in adults are secondary to a wide spectrum of benign and malignant pathologic conditions. Benign causes of bile duct strictures include iatrogenic causes, acute or chronic pancreatitis, choledocholithiasis, primary sclerosing cholangitis, IgG4-related sclerosing cholangitis, liver transplantation, recurrent pyogenic cholangitis, Mirizzi syndrome, acquired immunodeficiency s...

Prospective evaluation of advanced molecular markers and imaging techniques in patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911775
The American Journal of Gastroenterology; Levy MJ, Baron TH et. al.

May 14th, 2008 - Standard techniques for evaluating bile duct strictures have poor sensitivity for detection of malignancy. Newer imaging modalities, such as intraductal ultrasound (IDUS), and advanced cytologic techniques, such as digital image analysis (DIA) and fluorescence in situ hybridization (FISH), identify chromosomal abnormalities, and may improve sensitivity while maintaining high specificity. Our ai...

Identification of cholangiocarcinoma by using the Spyglass Spyscope system for peroral ...
https://doi.org/10.1016/j.cgh.2011.12.021
Clinical Gastroenterology and Hepatology : the Official C... Siddiqui AA, Mehendiratta V et. al.

Dec 19th, 2011 - It is a challenge to collect samples from bile duct strictures to diagnose patients with cholangiocarcinoma. We investigated the utility of the Spyglass Spyscope, a single-operator endoscope that is used to perform cholangiopancreatoscopy, to identify extrahepatic cholangiocarcinoma in patients who were not diagnosed with this disorder by endoscopic retrograde cholangiopancreatography (ERCP) cy...

Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy.
https://doi.org/10.1053/j.gastro.2007.12.009
Gastroenterology Ghazale A, Chari ST et. al.

Jan 28th, 2008 - Immunoglobulin (Ig)G4-associated cholangitis (IAC) is the biliary manifestation of a steroid-responsive multisystem fibroinflammatory disorder in which affected organs have a characteristic lymphoplasmacytic infiltrate rich in IgG4-positive cells. We describe clinical features, treatment response, and predictors of relapse in IAC and compare relapse rates in IAC with intrapancreatic vs proximal...

Postcholecystectomy syndrome (PCS).
https://doi.org/10.1016/j.ijsu.2009.10.008
International Journal of Surgery (London, England); Jaunoo SS, Mohandas S et. al.

Oct 27th, 2009 - The term postcholecystectomy syndrome (PCS) comprises a heterogeneous group of symptoms and findings in patients who have previously undergone cholecystectomy. Although rare, these patients may present with abdominal pain, jaundice or dyspeptic symptoms. Many of these complaints can be attributed to complications including bile duct injury, biliary leak, biliary fistula and retained bile duct s...

Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815445
Gastroenterology Eaton JE, Talwalkar JA et. al.

Jul 5th, 2013 - Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver disease that is heterogeneous in its presentation. PSC is characterized by chronic cholestasis associated with chronic inflammation of the biliary epithelium, resulting in multifocal bile duct strictures that can affect the entire biliary tree. Chronic inflammation leads to fibrosis involving the hepatic ...

Removable fully covered self-expandable metal stents in the treatment of common bile du...
https://doi.org/10.1055/s-2008-1077353
Endoscopy Cahen DL, Rauws EA et. al.

Aug 15th, 2008 - The aim of this study was to test the removability of fully covered self-expandable metal stents (FCSEMS) in patients with a benign common bile duct (CBD) stricture. A FCSEMS was inserted in six patients with a CBD stricture due to chronic pancreatitis who were considered to be unfit for surgery, and stent removal was attempted after predefined intervals of 4 and 6 months. FCSEMS were successfu...

Laser-guided repair of complex bile duct strictures.
https://doi.org/10.1159/000227276
Digestive Surgery; van Gulik T, Beek J et. al.

Nov 19th, 2009 - The repair of bile duct strictures (BDS) requires identification of healthy bile duct proximal to the stenosis. Identification may be difficult in complex bile duct injuries after cholecystectomy or partial liver resection. We describe a technique to identify the prestenotic bile duct using the sentinel light of a laser fiber passed through the catheter after percutaneous transhepatic biliary d...

A new partially covered nitinol stent for palliative treatment of malignant bile duct o...
https://doi.org/10.1055/s-0030-1256294
Endoscopy Costamagna G, Tringali A et. al.

Mar 1st, 2011 - Covered self-expanding metal stents (SEMSs) have proven effective for managing malignant bile duct strictures and may reduce risk of tumor ingrowth. A new nitinol partially covered biliary SEMS was prospectively evaluated. 70 patients with inoperable extrahepatic biliary obstructions were enrolled in a prospective multicenter trial, and followed up to 6 months or death, whichever came first. Pr...

Endoscopic Retrograde Cholangiopancreatography (ERCP) Based Sampling of Indeterminate Bile Duct Strictures
https://clinicaltrials.gov/ct2/show/NCT01580709

Sep 19th, 2016 - Differentiating malignant from benign bile duct strictures is a conundrum, since no diagnostic test is highly sensitive for diagnosing cancer. While ERCP is effective in palliating obstructive jaundice, standard diagnostic tools in ERCP have a low diagnostic sensitivity and confirm the stricture's etiology in <50% of cases. During the first ERCP, standard practice is to obtain routine cytology ...

Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope
https://clinicaltrials.gov/ct2/show/NCT02276157

Direct peroral cholangioscopy (DPOC) by using an ultra-slim upper endoscope provides optical endoscopic images of bile duct and permits various diagnostic or therapeutic intraductal interventions. Usually assisting accessories such as balloon catheter is demanded for an endoscope to advance into the bile duct. Possible diagnostic applications of DPOC include evaluation of indeterminate bile duc...

Diagnosis of Bile Duct Strictures
https://clinicaltrials.gov/ct2/show/NCT02000999

Jun 17th, 2018 - The purpose of this prospective study is to compare the diagnostic utility of two techniques (brush cytology + FISH and brush cytology + free DNA analysis) in the diagnosis of biliary strictures. Histologic diagnosis (biopsies) in conjunction with clinical and/or imaging follow-up will serve as the gold standard for diagnosis of malignancy. In order to do this the investigators will ask study p...

EUS - Guided Choledocho-duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Common Bile Duct Strictures
https://clinicaltrials.gov/ct2/show/NCT03000855

Jan 25th, 2018 - Malignant biliary obstruction is a common sequela of pancreatic cancers or distal bile duct cancers, and its development can hinder the use of chemotherapy, decrease patient quality of life and decrease survival. Malignant biliary obstruction is traditionally palliated with ERCP with metallic stent insertion. However, these stents are prone to obstruction due to tumour ingrowth. In addition, ER...

A Trial Comparing the Uncovered to the Covered Wallstent in the Palliation of Malignant Bile Duct Strictures
https://clinicaltrials.gov/ct2/show/NCT01047332

Apr 10th, 2017 - This is a prospective randomized trial conducted at 4 large teaching hospitals (Brigham and Women's Hospital, Massachusetts General Hospital, and Boston Medical Center, Boston, Massachusetts, and Mayo Clinic, Rochester, Minnesota). Malignancy is determined by pathology. Cancer stage is determined by transabdominal imaging and/or endoscopic ultrasound (EUS). Written informed consent is obtained ...

WallFlex Biliary Fully Covered (FC) Benign Stricture Study
https://clinicaltrials.gov/ct2/show/NCT01014390

The purpose of this study is to evaluate the safety and performance of the WallFlex® Biliary RX Fully Covered Stent as a treatment of biliary obstruction resulting from benign bile duct strictures.

Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures
https://clinicaltrials.gov/ct2/show/NCT01721174

Jan 25th, 2018 - Malignant bile duct obstruction is a common sequela of pancreatic cancers or distal bile duct cancers, and its development can hinder the use of chemotherapy, decrease patient quality of life, and decrease survival. To relieve obstructive jaundice as a result of the obstruction, endoscopic stent placement is usually required. The use self-expandable metal stents (SEMSs) have been shown to resul...