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About 7,770 results

ALLMedicine™ Cholangitis Center

Research & Reviews  2,749 results

rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholan...
https://doi.org/10.1016/j.jaut.2021.102775
Journal of Autoimmunity; Hitomi Y, Aiba Y et. al.

Dec 6th, 2021 - Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease that appears to be strongly influenced by genetic factors. Recently, an international meta-analysis of genome-wide association studies (GWAS) identified CC-Motif C...

QTc interval prolongation in the patients with primary biliary cholangitis.
https://doi.org/10.1111/anec.12925
Annals of Noninvasive Electrocardiology : the Official Jo... Wang Z, Qian R et. al.

Dec 3rd, 2021 - The QT interval prolongation was associated with fatal arrhythmias and cardiac death. However, there were not adequate data to clarify the situation of QT interval prolongation in primary biliary cholangitis (PBC) patients. The aim of this study w...

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
https://clinicaltrials.gov/ct2/show/NCT04685200

Dec 3rd, 2021 - In this single-site, small-scale prospective natural history study, we intend to recruit up to 40 patients with PSC diagnosed by standard clinical, biochemical, or imaging features (including up to 30 with a known diagnosis of IBD) and up to 90 co...

P022 Biologic Therapy and Therapeutic Drug Monitoring in Patients With Inflammatory Bow...
https://doi.org/10.14309/01.ajg.0000798688.16985.68
The American Journal of Gastroenterology; Varun J, Brian B et. al.

Dec 2nd, 2021 - P022 Biologic Therapy and Therapeutic Drug Monitoring in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.|2021|Varun J,Brian B,Esteban F,|

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Guidelines  21 results

Non-invasive diagnosis and follow-up of primary biliary cholangitis.
https://doi.org/10.1016/j.clinre.2021.101770
Clinics and Research in Hepatology and Gastroenterology; Corpechot C, Heurgue A et. al.

Aug 1st, 2021 - Primary biliary cholangitis (PBC) is a chronic inflammatory disease of the intra-hepatic bile ducts [1]. It is characterised biologically by chronic cholestasis associated with the presence of specific autoantibodies, and histologically by lesions...

Non-invasive diagnosis and follow-up of primary sclerosing cholangitis.
https://doi.org/10.1016/j.clinre.2021.101775
Clinics and Research in Hepatology and Gastroenterology; Chazouillères O, Potier P et. al.

Aug 1st, 2021 - Primary sclerosing cholangitis (PSC) is a rare and chronic cholestatic liver disease of unknown cause commonly associated with inflammatory bowel disease (IBD) and characterized by progressive obliterative fibro-inflammation of the biliary tree. A...

ASGE guideline on the management of cholangitis.
https://doi.org/10.1016/j.gie.2020.12.032
Gastrointestinal Endoscopy; Buxbaum JL, Buitrago C et. al.

May 24th, 2021 - Cholangitis is a GI emergency requiring prompt recognition and treatment. The purpose of this document from the American Society for Gastrointestinal Endoscopy's (ASGE) Standards of Practice Committee is to provide an evidence-based approach for m...

COVID-19 Pandemic: Which IBD Patients Need to Be Scoped-Who Gets Scoped Now, Who Can Wa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665406
Journal of Crohn's & Colitis; Ng SC, Mak JWY et. al.

Oct 22nd, 2020 - Endoscopy is an essential component in the management of inflammatory bowel disease [IBD]. There is a risk of SARS-CoV-2 transmission during endoscopic procedures. The International Organization for the study of IBD [IOIBD] has developed 11 positi...

AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With...
https://doi.org/10.1016/j.cgh.2019.07.011
Clinical Gastroenterology and Hepatology : the Official C... Bowlus CL, Lim JK et. al.

Jul 16th, 2019 - The purpose of this clinical practice update is to define key principles in the surveillance of hepatobiliary cancers including cholangiocarcinoma, gallbladder adenocarcinoma, and hepatocellular carcinoma in patients with primary sclerosing cholan...

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Drugs  6 results see all →

Clinicaltrials.gov  99 results

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
https://clinicaltrials.gov/ct2/show/NCT04685200

Dec 3rd, 2021 - In this single-site, small-scale prospective natural history study, we intend to recruit up to 40 patients with PSC diagnosed by standard clinical, biochemical, or imaging features (including up to 30 with a known diagnosis of IBD) and up to 90 co...

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)
https://clinicaltrials.gov/ct2/show/NCT04950764

Nov 24th, 2021 - The Effect of Hepatic Impairment on The Pharmacokinetics of Seladelpar: An Open-Label Study Following Oral Dosing of Seladelpar to Subjects with Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Saroglitazar Magnesium for Treatment of Primary Biliary Cholangitis
https://clinicaltrials.gov/ct2/show/NCT05133336

Nov 24th, 2021 - A Multicenter, Randomized, Double-blind, Placebo controlled, Phase 2b/3 Study to Evaluate the Efficacy and Safety of Saroglitazar Magnesium in Subjects with Primary Biliary Cholangitis

RESPONSE: Response to Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Control to or an Intolerance to Ursodeoxycholic Acid (UDCA)
https://clinicaltrials.gov/ct2/show/NCT04620733

Nov 11th, 2021 - To evaluate the treatment effect of seladelpar on composite biochemical improvement in cholestasis markers based on ALP and total bilirubin and to evaluate the safety of seladelpar over 12 months of treatment compared to placebo

Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)
https://clinicaltrials.gov/ct2/show/NCT04950127

Nov 10th, 2021 - This is a 2-part study in PBC participants with cholestatic pruritus and will evaluate the efficacy, safety and impact on health-related quality of life of linerixibat compared with placebo.

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News  217 results

Partner Perspectives: Moving Cholangiocarcinoma Into the Age of Targeted Therapy
https://www.onclive.com/view/partner-perspectives-moving-cholangiocarcinoma-into-the-age-of-targeted-therapy

Oct 6th, 2021 - Biliary tract cancers are an aggressive group of malignancies that historically have been very challenging to treat because of their anatomical location and limited responsiveness to systemic therapy.1-3 Biliary cancers arise from the epithelial l...

Screen for Primary Sclerosing Cholangitis in IBD?
https://www.medscape.com/viewarticle/958220

Sep 7th, 2021 - NEW YORK (Reuters Health) - About 2% of patients with inflammatory bowel diseases (IBD) will develop primary sclerosing cholangitis (PSC), with a higher prevalence in men than women, according to a new analysis. In a paper in Gastroenterology, the...

What’s your diagnosis?
https://www.mdedge.com/gihepnews/article/245290/mixed-topics/whats-your-diagnosis
Savan Kabaria, MD, Kalpesh G. Patel, MD et. al.

Sep 1st, 2021 - Choledocopyloric fistula secondary to peptic ulcer disease. This patient has a known history of prepyloric peptic ulcer disease and related gastric outlet obstruction requiring two previous dilations.

FDA Restricts Obeticholic Acid (Ocaliva) Over Serious Liver Injury Risk
https://www.medscape.com/viewarticle/951931

May 26th, 2021 - The risk for serious liver injury with obeticholic acid (Ocaliva, Intercept Pharmaceuticals) has prompted the US Food and Drug Administration (FDA) to restrict its use in patients with primary biliary cholangitis (PBC) and advanced cirrhosis.  The...

Despite New Ichthyosis Treatment Recommendations, 'Many Questions Still Exist'
https://www.medscape.com/viewarticle/949188

Apr 13th, 2021 - For as many disorders of cornification and types of ichthyosis that have been shown to benefit from retinoids, a seemingly equal number have no data or show no improvement. According to a consensus statement published in the February issue of Pedi...

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Patient Education  16 results see all →