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ALLMedicine™ Hereditary Colorectal Cancer Center

Research & Reviews  419 results

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells.
https://doi.org/10.1158/0008-5472.CAN-20-2896
Cancer Research; Bommi PV, Bowen CM et. al.

May 18th, 2021 - Lynch syndrome is the most common cause of hereditary colorectal cancer and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR-deficient (MMRd) co...

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133103
Clinical and Translational Gastroenterology; Jennelle LT, Dampier CH et. al.

May 17th, 2021 - Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer (CRC) syndrome characterized by accelerated adenoma development due to inherited (or de novo) mutations in the APC regulator of WNT signaling pathway (APC) gene. The mechanism ...

Incidence and Management of Rectal Cuff and Anal Transitional Zone Neoplasia in Patient...
https://doi.org/10.1097/DCR.0000000000001967
Diseases of the Colon and Rectum; Lee CHA, Kalady MF et. al.

May 7th, 2021 - Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly do...

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057911
Canadian Journal of Gastroenterology & Hepatology; Xie LJ, Ruan DD et. al.

May 6th, 2021 - A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer. Familia...

Universal Immunohistochemistry for Lynch Syndrome: A Systematic Review and Meta-analysi...
https://doi.org/10.1016/j.cgh.2021.04.021
Clinical Gastroenterology and Hepatology : the Official C... Eikenboom EL, van der Werf-'t Lam AS et. al.

Apr 22nd, 2021 - Lynch syndrome is a form of hereditary colorectal cancer (CRC) caused by pathogenic germline variants (PV) in DNA mismatch repair (MMR) genes. Currently, many Western countries perform universal immunohistochemistry testing on CRC to increase the ...

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Guidelines  11 results

Guidelines for the management of hereditary colorectal cancer from the British Society ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349
Gut Monahan KJ, Bradshaw N et. al.

Nov 29th, 2019 - Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporat...

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practic...
https://doi.org/10.6004/jnccn.2016.0108
Journal of the National Comprehensive Cancer Network : JN... Provenzale D, Gupta S et. al.

Aug 8th, 2016 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DN...

Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Gui...
http://www.jnccn.org/content/14/8/1010.full
Provenzale, D.,et al

Jul 31st, 2016 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DN.

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Clinicaltrials.gov  443 results

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells.
https://doi.org/10.1158/0008-5472.CAN-20-2896
Cancer Research; Bommi PV, Bowen CM et. al.

May 18th, 2021 - Lynch syndrome is the most common cause of hereditary colorectal cancer and is secondary to germline alterations in one of four DNA mismatch repair (MMR) genes. Here we aimed to provide novel insights into the initiation of MMR-deficient (MMRd) co...

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133103
Clinical and Translational Gastroenterology; Jennelle LT, Dampier CH et. al.

May 17th, 2021 - Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer (CRC) syndrome characterized by accelerated adenoma development due to inherited (or de novo) mutations in the APC regulator of WNT signaling pathway (APC) gene. The mechanism ...

Incidence and Management of Rectal Cuff and Anal Transitional Zone Neoplasia in Patient...
https://doi.org/10.1097/DCR.0000000000001967
Diseases of the Colon and Rectum; Lee CHA, Kalady MF et. al.

May 7th, 2021 - Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly do...

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp P...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057911
Canadian Journal of Gastroenterology & Hepatology; Xie LJ, Ruan DD et. al.

May 6th, 2021 - A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer. Familia...

Universal Immunohistochemistry for Lynch Syndrome: A Systematic Review and Meta-analysi...
https://doi.org/10.1016/j.cgh.2021.04.021
Clinical Gastroenterology and Hepatology : the Official C... Eikenboom EL, van der Werf-'t Lam AS et. al.

Apr 22nd, 2021 - Lynch syndrome is a form of hereditary colorectal cancer (CRC) caused by pathogenic germline variants (PV) in DNA mismatch repair (MMR) genes. Currently, many Western countries perform universal immunohistochemistry testing on CRC to increase the ...

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News  15 results

New medical ethics series debuts
https://www.mdedge.com/gihepnews/article/216342/mixed-topics/new-medical-ethics-series-debuts?channel=46646

Feb 1st, 2020 - Dear colleagues, The first issue of The New Gastroenterologist in 2020 consists of a particularly interesting array of articles and the introduction of a new medical ethics series! Dr. Vijaya Rao This month’s “In Focus” article, brought to you by.

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91
https://www.staging.medscape.com/viewarticle/914030

Jun 5th, 2019 - Henry T. Lynch, MD, PhD, world-renowned pioneer in the study of hereditary cancers, who discovered the most common form of hereditary colorectal cancer, known as Lynch syndrome, died on June 2 at the age of 91. Dr Henry Lynch "Dr Lynch has captain...

Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91
https://www.medscape.com/viewarticle/914030

Jun 5th, 2019 - Henry T. Lynch, MD, PhD, world-renowned pioneer in the study of hereditary cancers, who discovered the most common form of hereditary colorectal cancer, known as Lynch syndrome, died on June 2 at the age of 91. Dr Henry Lynch "Dr Lynch has captain...

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Patient Education  1 results see all →