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About 869 results

ALLMedicine™ Hereditary Colorectal Cancer Center

Research & Reviews  409 results

Progress Report: New insights into the prevention of CRC by colonoscopic surveillance i...
https://doi.org/10.1007/s10689-020-00225-x 10.1158/1055-9965.EPI-16-0693 10.1007/s10689-018-00117-1 10.1038/s41436-019-0596-9 10.1016/0016-5085(93)90368-M 10.1007/BF02552613 10.1016/S0140-6736(95)91016-6 10.1016/j.cgh.2009.10.003 10.1007/s10689-013-9610-6 10.3109/00365528708991489 10.1016/0002-9343(89)90296-9 10.1016/0016-5085(95)90688-6 10.1016/S0016-5085(00)70168-5 10.1053/j.gastro.2007.08.019 10.1053/j.gastro.2010.02.053 10.1111/j.1463-1318.2008.01702.x 10.1111/codi.12778 10.1111/j.1399-0004.2011.01802.x 10.1002/ijc.33224 10.1053/j.gastro.2019.01.260 10.1053/j.gastro.2019.12.022 10.1016/j.gie.2019.04.227 10.1053/j.gastro.2019.09.003 10.1177/2050640618783554 10.1053/j.gastro.2003.10.043 10.1136/gut.33.6.783 10.1016/S1470-2045(12)70109-2 10.1038/modpathol.2017.39 10.1002/ijc.31300 10.1007/BF02555362 10.1136/gut.50.3.382 10.1007/s10689-016-9899-z 10.1136/gut.2004.048132 10.15252/embj.201591739 10.1136/gutjnl-2015-309675 10.1136/gutjnl-2016-311403 10.1136/gutjnl-2017-314057 10.1186/s13053-017-0078-5 10.1186/s13053-019-0127-3 10.1186/s13053-019-0106-8 10.1200/JCO.2014.57.8088 10.1200/JCO.2018.78.4777 10.1053/j.gastro.2018.07.030 10.1053/j.gastro.2019.12.032 10.1053/j.gastro.2018.05.020 10.1053/j.gastro.2008.01.015 10.1007/s10689-016-9882-8 10.1158/1940-6207.CAPR-11-0519 10.1038/modpathol.2011.209 10.1016/j.cgh.2019.08.043 10.1053/j.gastro.2015.07.036 10.1038/ajg.2014.435 10.1055/a-1016-4977 10.1136/gutjnl-2019-319915 10.1038/nrgastro.2014.229
Familial Cancer; Vasen HFA

Jan 19th, 2021 - Lynch syndrome is the most frequent hereditary colorectal cancer (CRC) syndrome, affecting approximately 1 in 300 in the Western population. It is caused by pathogenic variants in the mismatch repair (MMR) genes including MLH1, MSH2 (EPCAM), MSH6 ...

Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797148
BMC Cancer; Xu Y, Li C et. al.

Jan 10th, 2021 - Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare, with conflicting results. This study aimed to compare the long-term outcomes between patients...

Evaluating the utility of tumour mutational signatures for identifying hereditary color...
https://doi.org/10.1136/gutjnl-2019-320462
Gut Georgeson P, Pope BJ et. al.

Jan 8th, 2021 - Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH underlie hereditary colorectal cancer (CRC) and polyposis syndromes. We evaluated the robustness and discriminatory potential of t...

Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.
https://doi.org/10.1016/j.cgh.2020.12.007
Clinical Gastroenterology and Hepatology : the Official C... Fujita M, Liu X et. al.

Dec 14th, 2020 - Colorectal cancer (CRC) is one of the most common cancers in the world. A small proportion of CRCs can be attributed to recognizable hereditary germline variants of known CRC susceptibility genes. To better understand cancer risk, it is necessary ...

Using chatbots to screen for heritable cancer syndromes in patients undergoing routine ...
https://doi.org/10.1136/jmedgenet-2020-107294
Journal of Medical Genetics; Heald B, Keel E et. al.

Nov 10th, 2020 - Hereditary colorectal cancer (HCRC) syndromes account for 10% of colorectal cancers but remain underdiagnosed. This feasibility project tested the utility of an artificial intelligence-based chatbot deployed to patients scheduled for colonoscopy t...

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Guidelines  11 results

Guidelines for the management of hereditary colorectal cancer from the British Society ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349
Gut Monahan KJ, Bradshaw N et. al.

Nov 29th, 2019 - Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporat...

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practic...
https://doi.org/10.6004/jnccn.2016.0108
Journal of the National Comprehensive Cancer Network : JN... Provenzale D, Gupta S et. al.

Aug 8th, 2016 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DN...

Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Gui...
http://www.jnccn.org/content/14/8/1010.full
Provenzale, D.,et al

Jul 31st, 2016 - This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DN.

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Clinicaltrials.gov  433 results

Progress Report: New insights into the prevention of CRC by colonoscopic surveillance i...
https://doi.org/10.1007/s10689-020-00225-x 10.1158/1055-9965.EPI-16-0693 10.1007/s10689-018-00117-1 10.1038/s41436-019-0596-9 10.1016/0016-5085(93)90368-M 10.1007/BF02552613 10.1016/S0140-6736(95)91016-6 10.1016/j.cgh.2009.10.003 10.1007/s10689-013-9610-6 10.3109/00365528708991489 10.1016/0002-9343(89)90296-9 10.1016/0016-5085(95)90688-6 10.1016/S0016-5085(00)70168-5 10.1053/j.gastro.2007.08.019 10.1053/j.gastro.2010.02.053 10.1111/j.1463-1318.2008.01702.x 10.1111/codi.12778 10.1111/j.1399-0004.2011.01802.x 10.1002/ijc.33224 10.1053/j.gastro.2019.01.260 10.1053/j.gastro.2019.12.022 10.1016/j.gie.2019.04.227 10.1053/j.gastro.2019.09.003 10.1177/2050640618783554 10.1053/j.gastro.2003.10.043 10.1136/gut.33.6.783 10.1016/S1470-2045(12)70109-2 10.1038/modpathol.2017.39 10.1002/ijc.31300 10.1007/BF02555362 10.1136/gut.50.3.382 10.1007/s10689-016-9899-z 10.1136/gut.2004.048132 10.15252/embj.201591739 10.1136/gutjnl-2015-309675 10.1136/gutjnl-2016-311403 10.1136/gutjnl-2017-314057 10.1186/s13053-017-0078-5 10.1186/s13053-019-0127-3 10.1186/s13053-019-0106-8 10.1200/JCO.2014.57.8088 10.1200/JCO.2018.78.4777 10.1053/j.gastro.2018.07.030 10.1053/j.gastro.2019.12.032 10.1053/j.gastro.2018.05.020 10.1053/j.gastro.2008.01.015 10.1007/s10689-016-9882-8 10.1158/1940-6207.CAPR-11-0519 10.1038/modpathol.2011.209 10.1016/j.cgh.2019.08.043 10.1053/j.gastro.2015.07.036 10.1038/ajg.2014.435 10.1055/a-1016-4977 10.1136/gutjnl-2019-319915 10.1038/nrgastro.2014.229
Familial Cancer; Vasen HFA

Jan 19th, 2021 - Lynch syndrome is the most frequent hereditary colorectal cancer (CRC) syndrome, affecting approximately 1 in 300 in the Western population. It is caused by pathogenic variants in the mismatch repair (MMR) genes including MLH1, MSH2 (EPCAM), MSH6 ...

Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797148
BMC Cancer; Xu Y, Li C et. al.

Jan 10th, 2021 - Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare, with conflicting results. This study aimed to compare the long-term outcomes between patients...

Evaluating the utility of tumour mutational signatures for identifying hereditary color...
https://doi.org/10.1136/gutjnl-2019-320462
Gut Georgeson P, Pope BJ et. al.

Jan 8th, 2021 - Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH underlie hereditary colorectal cancer (CRC) and polyposis syndromes. We evaluated the robustness and discriminatory potential of t...

Population-based Screening for Hereditary Colorectal Cancer Variants in Japan.
https://doi.org/10.1016/j.cgh.2020.12.007
Clinical Gastroenterology and Hepatology : the Official C... Fujita M, Liu X et. al.

Dec 14th, 2020 - Colorectal cancer (CRC) is one of the most common cancers in the world. A small proportion of CRCs can be attributed to recognizable hereditary germline variants of known CRC susceptibility genes. To better understand cancer risk, it is necessary ...

Using chatbots to screen for heritable cancer syndromes in patients undergoing routine ...
https://doi.org/10.1136/jmedgenet-2020-107294
Journal of Medical Genetics; Heald B, Keel E et. al.

Nov 10th, 2020 - Hereditary colorectal cancer (HCRC) syndromes account for 10% of colorectal cancers but remain underdiagnosed. This feasibility project tested the utility of an artificial intelligence-based chatbot deployed to patients scheduled for colonoscopy t...

see more →

News  15 results

New medical ethics series debuts
https://www.mdedge.com/gihepnews/article/216342/mixed-topics/new-medical-ethics-series-debuts?channel=46646

Feb 1st, 2020 - Dear colleagues, The first issue of The New Gastroenterologist in 2020 consists of a particularly interesting array of articles and the introduction of a new medical ethics series! Dr. Vijaya Rao This month’s “In Focus” article, brought to you by.

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91
https://www.staging.medscape.com/viewarticle/914030

Jun 5th, 2019 - Henry T. Lynch, MD, PhD, world-renowned pioneer in the study of hereditary cancers, who discovered the most common form of hereditary colorectal cancer, known as Lynch syndrome, died on June 2 at the age of 91. Dr Henry Lynch "Dr Lynch has captain...

Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91
https://www.medscape.com/viewarticle/914030

Jun 5th, 2019 - Henry T. Lynch, MD, PhD, world-renowned pioneer in the study of hereditary cancers, who discovered the most common form of hereditary colorectal cancer, known as Lynch syndrome, died on June 2 at the age of 91. Dr Henry Lynch "Dr Lynch has captain...

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Patient Education  1 results see all →