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About 1,123 results

ALLMedicine™ Hirschsprung Disease Center

Research & Reviews  436 results

Autopsy Study of Calretinin Immunohistochemistry in the Anorectal Canal in Young Infant...
https://doi.org/10.1177/10935266211030172
Pediatric and Developmental Pathology : the Official Jour... Rytting H, Dureau ZJ et. al.

Jul 17th, 2021 - Absent submucosal ganglion cells in biopsies 1-3 cm above the pectinate line establishes the pathologic diagnosis of Hirschsprung Disease (HD). Calretinin stains both ganglion cells and their mucosal neurites and has gained importance in HD diagno...

Post-operative colonic manometry in children with Hirschsprung disease: A systematic re...
https://doi.org/10.1111/nmo.14201
Neurogastroenterology and Motility : the Official Journal... Evans-Barns HME, Swannjo J et. al.

Jul 3rd, 2021 - A significant proportion of children experience bowel dysfunction (including constipation and fecal incontinence) following surgical repair of Hirschsprung disease (HD). Persistent symptoms are thought to relate to underlying colonic and/or anorec...

A novel case of concurrent occurrence of demyelinating-polyneuropathy-causing PMP22 dup...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228911
BMC Neurology; Matsuda N, Ootsuki K et. al.

Jun 27th, 2021 - Hereditary motor and sensory neuropathy, also referred to as Charcot-Marie-Tooth disease (CMT), is most often caused by a duplication of the peripheral myelin protein 22 (PMP22) gene. This duplication causes CMT type 1A (CMT1A). CMT1A rarely occur...

Double check: diagnosis and management of adult Hirschsprung disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230937
BMJ Case Reports; Moynagh N, Rogers AC et. al.

Jun 25th, 2021 - Hirschsprung disease (HD) is a gut motility disorder usually diagnosed acutely in infancy, although variants of HD may present later in life with indolent symptoms. This report highlights the rarity of diagnosing HD and hypoganglionosis in adultho...

Motor behavior of mouse large intestine: A Minireview.
https://doi.org/10.1111/nmo.14206
Neurogastroenterology and Motility : the Official Journal... Wood JD

Jun 20th, 2021 - Mice with a recessive gene which reduces the number of ganglion cells of the distal colon and rectum and produces megacolon, imitating Hirschsprung disease, are discussed as a model for integrative control of the large intestinal smooth musculatur...

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Clinicaltrials.gov  6 results

Hirschsprung Disease Genetic Study
https://clinicaltrials.gov/ct2/show/NCT00478712

May 1st, 2020 - Hirschsprung disease (HSCR) is a birth defect resulting from the absence of nerve (ganglion) cells in the gastrointestinal tract. Hirschsprung disease has a population incidence of 1/5000 live births and most often occurs as an isolated condition....

MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitis
https://clinicaltrials.gov/ct2/show/NCT02857205

Sep 13th, 2018 - Primary objective : Characterize intestinal microbiota in patients with or without HAEC. Secondary objectives : Look for a difference in microbiota composition between patients with or without HAEC ; Study the evolution with age of the microbiota ...

Neuropsychological Development and Functional Outcome Sin Children With Hirschsprung Disease at School Age
https://clinicaltrials.gov/ct2/show/NCT03406741

Jan 24th, 2018 - Hirschsprung's disease (HD) is a rare congenital disease (1:5000) characterized by neonatal functional low bowel obstruction that is caused by aganglionosis of the distal bowel. HD treatment consists in surgery of colonic reduction in the early ch...

Laparoscopic Assisted Pull-through Versus Other Surgical Procedures for Treatment of Hirschsprung Disease
https://clinicaltrials.gov/ct2/show/NCT03269812

Sep 1st, 2017 - Hirschsprung,s disease (HD) is a relatively common cause of intestinal obstruction in the newborn[1,2], The main goal in the treatment of patients with Hirschsprung,s disease is to resect the aganglionic segment and pull down the Normo-ganglionic ...

A Trial on Conservative Treatment for Infants' Hirschsprung Disease
https://clinicaltrials.gov/ct2/show/NCT01985646

Nov 15th, 2013 - The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in infants with short or normal-segment Hirschsprung disease.

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News  7 results

Hirschsprung Disease Tied to Increased Risk of Inflammatory Bowel Disease
https://www.medscape.com/viewarticle/945801

Feb 16th, 2021 - (Reuters Health) - Children with Hirschsprung disease may be at increased risk for developing inflammatory bowel disease, a Canadian study suggests. Researchers examined data on 716 children diagnosed with Hirschsprung since 1991 in Ontario, as we...

Clinical Practice Guidelines for the Management of Rectosigmoid Hirschsprung Disease (ERNICA, 2020)
https://reference.staging.medscape.com/viewarticle/936770

Sep 3rd, 2020 - Clinical practice guidelines for the management of rectosigmoid Hirschsprung disease were released in June 2020 by the European Reference Network for Rare Inherited and Congenital [digestive] Anomalies (ERNICA).[1] Diagnosis of Hirschsprung Diseas...

Clinical Practice Guidelines for the Management of Rectosigmoid Hirschsprung Disease (ERNICA, 2020)
https://reference.medscape.com/viewarticle/936770

Sep 3rd, 2020 - Clinical practice guidelines for the management of rectosigmoid Hirschsprung disease were released in June 2020 by the European Reference Network for Rare Inherited and Congenital [digestive] Anomalies (ERNICA).[1] Diagnosis of Hirschsprung Diseas...

Hirschsprung Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/935805

Aug 28th, 2020 - Hirschsprung disease is a form of megacolon that occurs when part or all of the large intestine or antecedent parts of the gastrointestinal tract have no ganglion cells and therefore cannot function. During normal prenatal development, cells from ...

Solving stool refusal
https://www.mdedge.com/familymedicine/article/141454/mental-health/solving-stool-refusal
Pediatric News; Barbara J. Howard, MD

Jun 28th, 2017 - When parents bring in their delightful, verbal 3-year-old for refusing to poop on the potty, it may seem laughable. But with impending preschool and costs of diapers, stool refusal can be a major aggravation for families! Fortunately, stool refusa.

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