ALLMedicine™ Constipation Center

Mar 18th, 2023 - Prokinetic agents, specifically 5-hydroxytryptamine type 4 (5-HT4) receptor agonists, have been shown to provide relief in chronic idiopathic constipation (CIC). The first 5-HT4 agonists were initially withdrawn from use owing to associations with...

Mar 18th, 2023 - Functional constipation (FC) is considered the most common functional gastrointestinal disorder in children with a pooled global prevalence of 14.4% (95% confidence interval: 11.2-17.6) when diagnosed based on the Rome IV criteria. Its pathophysio...

Mar 16th, 2023 - Approach Considerations Laboratory studies are not specific for hernia but may be useful for general medical evaluation. Imaging studies are not required in the normal workup of a hernia [7, 8] ; however, radiography, computed tomography (CT), or ...

Mar 16th, 2023 - History The clinical features that cause patients to seek medical care include polyuria, polydipsia, bouts of dehydration (sometimes associated with fever), bone deformities, and impaired growth. Less often, the reasons for investigation are labor...

Mar 16th, 2023 - Diabetes Mellitus causes a systemic oxidative stress due in part to the hyperglycemia and the reactive oxygen species generated. Up to 75% of diabetic patients present with an autonomic neuropathy affecting the Enteric Nervous System. Deficits in ...

Jan 16th, 2023 - Constipation is a common diagnosis among hospitalized patients. It results in considerable morbidity in elderly patients, healthcare utilization and economic burden. Laxatives are commonly prescribed but poorly monitored due to benign side effect ...

Jun 24th, 2022 - Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of med...

Mar 7th, 2021 - Multiple system atrophy (MSA) is a neurodegenerative disorder primarily characterized by autonomic failure plus parkinsonism or cerebellar ataxia. The diagnosis may be challenging and is usually made at a tertiary care center. The long-term manage...

Nov 23rd, 2019 - Chronic constipation is a common disorder with a reported prevalence ranging from 3% to 27% in the general population. Several management strategies, including diagnostic tests, empiric treatments, and specific treatments, have been developed. Our...

Nov 5th, 2019 - Medical Management of Opioid-Induced Constipation.|2019|Rao VL,Micic D,Davis AM,|adverse effects,therapeutic use,therapeutic use,therapeutic use,analogs & derivatives,therapeutic use,therapeutic use,drug therapy,therapeutic use,

Mar 10th, 2023 - Bile acid diarrhoea (BAD) is an under-recognised but common condition of chronic watery diarrhoea. BAD may be secondary to ileal disease affecting the reabsorption and the enterohepatic circulation of bile acids (bile acid malabsorption) or can be...

Mar 9th, 2023 - INCB7839 is an inhibitor of the ADAM (A Disintegrin and Metalloprotease) 10 and 17 proteases. Neuronal activity regulates glioma growth through neuroligin-3 (NLGN3). ADAM 10 is the protease responsible for NLGN3 release into the tumor microenviron...

Mar 9th, 2023 - Chemotherapy is defined as treatment with chemical drugs that prevent the proliferation of malignant tumor cells, kill the cell or stop its function. Since these chemical agents affect healthy cells as well as diseased cells, they can cause seriou...

Mar 9th, 2023 - Expanded Access Program Design: The purpose of the Expanded Access Program is to provide oral Domperidone to patients' ≥12 years of age where, according to the investigator's judgment, a prokinetic effect is needed for the relief of refractory gas...

Mar 9th, 2023 - The EORTC QLQ-C30, a patient-reported outcome measure (PROM) that is available in 110 different languages, has been used in thousands of clinical cancer trials worldwide. The QLQ-C30 is composed of six functioning scales (including a measure for g...

Feb 24th, 2023 - More on ‘intellectual constipation’ Regarding your editorial, “From debate to stalemate and hate: An epidemic of intellectual constipation” (Current Psychiatry, January 2023, p. 3-4, doi:10.

Feb 16th, 2023 - In the first randomized comparison of targeted agents for acute lymphoblastic leukemia (ALL), ponatinib (Iclusig) prevailed over imatinib for untreated Philadelphia chromosome-positive (Ph+) cases. More than twice as many patients treated with pon...

Feb 8th, 2023 - A selective kappa opioid receptor agonist in patients with notalgia paresthetica led to "modestly" greater improvements in itchiness over placebo, but was associated with adverse events, a randomized phase II trial showed. At 8 weeks, improvements...

Jan 31st, 2023 - In children with drug-resistant epilepsy, the modified Atkins and ketogenic diets were more effective than usual care in achieving large short-term reductions in seizures and short-term seizure freedom, a systematic review and network meta-analysi...

Jan 30th, 2023 - Although rare, acute hepatic porphyrias (AHPs) may be more common than previously thought, particularly among women between ages 15 and 50, according to a new clinical practice update from the American Gastroenterological Association. For acute at.