ALLMedicine™ Hirschsprung Disease Center

Mar 16th, 2023 - Hirschsprung disease (HSCR) is a congenital colonic aganglionosis. Many HSCR patients develop enterocolitis despite surgical resection. The pathophysiology of this inflammatory process is poorly understood. We compared transcriptional profiles and...

Feb 22nd, 2023 - A small number of Hirschsprung disease (HD) patients develop inflammatory bowel disease (IBD)-like symptoms after pullthrough surgery. The etiology and pathophysiology of Hirschsprung-associated IBD (HD-IBD) remains unknown. This study aims to fur...

Feb 16th, 2023 - METTL3, an mRNA m6A methyltransferase, has been implicated in various steps of mRNA metabolism, such as stabilization, splicing, nuclear transportation, translation, and degradation. However, whether METTL3 dysregulation is involved in Hirschsprun...

Feb 15th, 2023 - To evaluate outcomes of adopting the Swenson-like technique in transanal pull-through for Hirschsprung disease (HD) at a children's institution in Southeast Asia. A retrospective chart review was performed over 42 months at a safety-net pediatric ...

Feb 6th, 2023 - Robotic colorectal surgery allows adult and pediatric surgeons to overcome the technical limitations of laparoscopic surgery. It also provides improved ergonomics in the field of surgery. Robotic surgery has several advantages in colorectal operat...

Jan 30th, 2023 - Hirschsprung disease (HSCR) is a birth defect resulting from the absence of nerve (ganglion) cells in the gastrointestinal tract. Hirschsprung disease has a population incidence of 1/5000 live births and most often occurs as an isolated condition....

Dec 19th, 2022 - Hirschsprung disease (HD) is a distinctive congenital disease with the absence of ganglion cells in the distal intestine leads to distal bowel obstruction and defecation disorders. HD is a rare disease, with a reported incidence of 1:5,000, requir...

Dec 2nd, 2022 - A multi-center, prospective,randomized, non-blind, controlled study was conducted to investigate the effects of different pre-operative nutritional support modes on perioperative nutritional status, surgical treatment success rate, and rehabilitat...

Dec 1st, 2022 - Hirschsprung disease (HSCR) is characterized by the absence of ganglion cells (aganglionosis) in the distal bowel extending proximally for varying distances that results in persistent spasm in the affected bowel and functional intestinal obstructi...

Jun 22nd, 2022 - Hirschsprung disease (HD) is associated with significant morbidities including long-term bowel dysfunction. The aim of this study was to update national and regional trends in the epidemiology and inpatient care utilization of HD in the United Sta...

Feb 16th, 2021 - (Reuters Health) - Children with Hirschsprung disease may be at increased risk for developing inflammatory bowel disease, a Canadian study suggests. Researchers examined data on 716 children diagnosed with Hirschsprung since 1991 in Ontario, as we...

Sep 3rd, 2020 - Clinical practice guidelines for the management of rectosigmoid Hirschsprung disease were released in June 2020 by the European Reference Network for Rare Inherited and Congenital [digestive] Anomalies (ERNICA).[1] Diagnosis of Hirschsprung Diseas...

Sep 3rd, 2020 - Clinical practice guidelines for the management of rectosigmoid Hirschsprung disease were released in June 2020 by the European Reference Network for Rare Inherited and Congenital [digestive] Anomalies (ERNICA).[1] Diagnosis of Hirschsprung Diseas...

Aug 28th, 2020 - Hirschsprung disease is a form of megacolon that occurs when part or all of the large intestine or antecedent parts of the gastrointestinal tract have no ganglion cells and therefore cannot function. During normal prenatal development, cells from ...

Jun 28th, 2017 - When parents bring in their delightful, verbal 3-year-old for refusing to poop on the potty, it may seem laughable. But with impending preschool and costs of diapers, stool refusal can be a major aggravation for families! Fortunately, stool refusa.