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ALLMedicine™ Shigellosis Center

Research & Reviews  197 results

Preferences for shigellosis-related health promotion materials for gay, bisexual, and o...
https://doi.org/10.1097/OLQ.0000000000001579
Sexually Transmitted Diseases; Respress E, Evener SL et. al.

Nov 8th, 2021 - Shigellosis, an acute diarrheal disease, is the third most common bacterial infection in the United States. Shigellosis most commonly affects children under the age of 5; however, clusters and outbreaks of shigellosis have been reported among gay,...

Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vacc...
https://doi.org/10.1021/acsinfecdis.1c00345
ACS Infectious Diseases; Baruah N, Ahamad N et. al.

Nov 5th, 2021 - With the acquirement of antibiotic resistance, Shigella has resulted in multiple epidemics of shigellosis, an infectious diarrheal disease, causing thousands of deaths per year. Unfortunately, there are no licensed vaccines, primarily due to low o...

Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of im...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589205
PLoS Neglected Tropical Diseases; Citiulo F, Necchi F et. al.

Oct 14th, 2021 - No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple serotypes of S. flexneri, which change regionally and globally, also cause significant disea...

An approach to chimeric subunit immunogen provides efficient protection against toxicit...
https://doi.org/10.1016/j.intimp.2021.108132
International Immunopharmacology; Felegary A, Nazarian S et. al.

Sep 12th, 2021 - Shigellosis is one of the infectious diseases causing severe intestinal illness in human beings. Development of an effective vaccine against Shigella is a key to deal with this bacterium. The present study aimed at evaluation of the antibody respo...

Update on Shigella and Nontyphoidal Salmonella Antimicrobial Drug Resistance: Implicati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522753
Antimicrobial Agents and Chemotherapy; Poramathikul K, Wojnarski M et. al.

Aug 17th, 2021 - Information on causative diarrheal pathogens and their associated antimicrobial susceptibility remains limited for Cambodia. This study describes antimicrobial resistance patterns for Shigella and nontyphoidal Salmonella isolates collected in Camb...

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Drugs  26 results see all →

Clinicaltrials.gov  4 results

Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a
https://clinicaltrials.gov/ct2/show/NCT02646371

Jan 27th, 2021 - Flexyn2a is a bioconjugate candidate vaccine that is able to induce an humoral immune response specific for the 2a-antigen of Shigella flexneri 2a bacteria. Healthy adult volunteers naïve for Shigella flexneri 2a infections at screening will recei...

Shigella Sonnei OSPC-rDT Conjugate Vaccine
https://clinicaltrials.gov/ct2/show/NCT01399424

Jul 2nd, 2017 - The active ingredient of this Shigella sonnei O-SP-core conjugate vaccine is a saccharide-protein conjugate composed of a fragment of S. sonnei LPS. The saccharide component consists of an average of 3.5 repeat units of the O-SP plus the core regi...

Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections
https://clinicaltrials.gov/ct2/show/NCT01638039

Jul 11th, 2012 - The aim of this study is to accelerate the development of vaccine candidates against diarrheal diseases caused by Shigella and Enterotoxigenic Escherichia coli (ETEC). We plan to identify cases of laboratory-proven shigellosis and ETEC-associated ...

Zinc Supplementation in Shigella Patients
https://clinicaltrials.gov/ct2/show/NCT00321126

May 3rd, 2006 - Study design: The study was a double blind randomised clinical trial using zinc and placebo using multivitamin base.Study subjects: Fifty six children of both sex aged between 12-59 months were studied in the study ward who attended the Dhaka Hosp...

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News  8 results

CDC Mandates Measles Quarantine for Afghanistan Evacuees
https://www.medscape.com/viewarticle/959222

Sep 22nd, 2021 - Evacuees of Afghanistan who have arrived in the United States must be vaccinated against measles and undergo quarantine for 21 days, according to a health advisory issued September 20 by the Centers for Disease Control and Prevention (CDC). At the...

Shigellosis
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/410868

Shigellosis is a highly contagious diarrheal illness caused by the Shigella bacteria. Find out about the disease, people at risk, and steps you can take to prevent infection.

Fast Five Quiz: How Much Do You Know About Common Conditions Associated With Diarrhea?
https://reference.medscape.com/viewarticle/900215_6

Aug 7th, 2018 - General supportive care of patients with shigellosis includes: Infection with Shigella is normally self-limited. The average duration of gastrointestinal symptoms of untreated shigellosis is 7 days Antibiotic treatment is indicated in some patient...

Ciprofloxacin- and Azithromycin-Nonsusceptible Shigellosis in the United States - Health Alert Network (HAN) No. 379
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/358956

CDC continues to receive new reports of infections with Shigella strains that are not susceptible to ciprofloxacin and/or azithromycin, the antimicrobial agents most commonly used to treat shigellosis. Most cases have been reported among gay, bise...

CDC: Some Shigella strains show reduced ciprofloxacin susceptibility
https://www.mdedge.com/gihepnews/article/136209/antimicrobial-resistant-infections/cdc-some-shigella-strains-show-reduced
Sharon Worcester, MDedge News

Apr 21st, 2017 - The Centers for Disease Control and Prevention has identified an increase in Shigella isolates with reduced susceptibility to ciprofloxacin, and has released an official health advisory outlining new recommendations for clinical diagnosis, managem.

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