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About 84,203 results

ALLMedicine™ Colorectal Cancer Center

Research & Reviews  28,697 results

The impact of KRAS mutation, microsatellite instability, and tumor laterality on the pr...
https://doi.org/10.1016/j.surg.2021.10.043
Surgery Tran CG, Goffredo P et. al.

Dec 7th, 2021 - KRAS mutations, microsatellite instability, and tumor location have been found to be significant prognostic factors in colorectal cancer. The interaction between these variables and its effect on overall survival in nonmetastatic colon cancer has ...

Peritoneal recurrence of colorectal cancer with microsatellite instability: Is immunoth...
https://doi.org/10.1016/j.jviscsurg.2021.09.005
Journal of Visceral Surgery; Gavignet C, Hobeika C et. al.

Dec 7th, 2021 - A 67-year-old man was treated with systemic chemotherapy and cytoreductive surgery for microsatellite instable (MSI), deficient mismatch repair (dMMR) right colonic cancer with peritoneal metastases. Disease was controlled only when anti-PD1 and a...

International trends in cancer incidence in middle-aged and older adults in 44 countries.
https://doi.org/10.1016/j.jgo.2021.11.011
Journal of Geriatric Oncology; Pilleron S, Alqurini N et. al.

Dec 7th, 2021 - We examine international incidence trends of lung, colorectal, prostate, and breast cancers, as well as all cancers combined excluding non-melanoma skin cancer (NMSC) in adults aged 50 and older, over a fifteen-year period using data from 113 high...

Triterpenoids of Rhus chinensis Supressed Colorectal Cancer Progress by Enhancing Antit...
https://doi.org/10.1080/01635581.2021.2009523
Nutrition and Cancer; Wang G, Yu Y et. al.

Dec 7th, 2021 - The absence of CD8+ T cells in the tumor center has become a major obstacle in the immunotherapy of colorectal cancer. Therefore, new therapeutic strategies are urgently needed to promote the accumulation of CD8+ T cells in the tumor center. Previ...

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Guidelines  87 results

Updates on age to start and stop colorectal cancer screening: recommendations from the ...
https://doi.org/10.1016/j.gie.2021.06.012
Gastrointestinal Endoscopy; Patel SG, May FP et. al.

Nov 20th, 2021 - This document is a focused update to the 2017 colorectal cancer (CRC) screening recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer, which represents the American College of Gastroenterology, the American Gastroenterologica...

Updates on Age to Start and Stop Colorectal Cancer Screening: Recommendations From the ...
https://doi.org/10.1053/j.gastro.2021.10.007
Gastroenterology Patel SG, May FP et. al.

Nov 20th, 2021 - This document is a focused update to the 2017 colorectal cancer (CRC) screening recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer, which represents the American College of Gastroenterology, the American Gastroenterologica...

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition...
https://doi.org/10.1002/bjs.11902
The British Journal of Surgery; Seppälä TT, Latchford A et. al.

May 28th, 2021 - Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and the hete...

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation State...
https://doi.org/10.1001/jama.2021.6238
JAMA , Davidson KW et. al.

May 19th, 2021 - Colorectal cancer is the third leading cause of cancer death for both men and women, with an estimated 52 980 persons in the US projected to die of colorectal cancer in 2021. Colorectal cancer is most frequently diagnosed among persons aged 65 to ...

Patient and Patient Group Engagement in Cancer Clinical Trials: A Stakeholder Charter.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167642
Current Oncology (Toronto, Ont.); Michaud S, Needham J et. al.

May 1st, 2021 - Background-to guide the implementation of patient centricity and engagement in cancer clinical trials (CTs) and to operationalize the Canadianized version of the Clinical Trials Transformation Initiative (C-CTTI) model, the development of a charte...

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Drugs  108 results see all →

Clinicaltrials.gov  1,351 results

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer
https://clinicaltrials.gov/ct2/show/NCT02298959

Dec 3rd, 2021 - PRIMARY OBJECTIVE: I. To determine the safety, tolerability and recommended phase II dosing for the combination of ziv-aflibercept plus MK-3475 (pembrolizumab) in patients with unresectable stage III or stage IV melanoma, renal cell cancer, ovaria...

Phase II Study of Tirelizumab Combined With Cetuximab and Irinotecan in the Treatment of Recurrent, Refractory mCRC
https://clinicaltrials.gov/ct2/show/NCT05143099

Dec 3rd, 2021 - This is a single arm, open phase II study to evaluate the efficacy and safety of tirelizumab combined with cetuximab + irinotecan in the treatment of Ras wild-type recurrent and refractory colorectal cancer. This study will include Ras wild-type c...

Multilevel Intervention Based on Colorectal Cancer (CRC) and Cervical Cancer Self-screening in Rural, Segregated Areas
https://clinicaltrials.gov/ct2/show/NCT04471194

Dec 2nd, 2021 - In this study, the investigators will deliver self-sampling human papillomavirus (HPV) tests and fecal immunochemical test (FIT) kits, as well as adapted cancer screening educational materials, by mail to 110 women who are out-of-date for both cer...

An Observational Study of Avastin in Participants With Metastatic Colorectal Cancer (KORALLE)
https://clinicaltrials.gov/ct2/show/NCT01775644

Dec 2nd, 2021 - This observational multicenter study will evaluate the differences in progression-free survival defined in specific subgroups of participants with metastatic colorectal cancer receiving bevacizumab (Avastin). Further, safety and efficacy in daily ...

Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding
https://clinicaltrials.gov/ct2/show/NCT05141617

Dec 2nd, 2021 - Oxaliplatin is used as the first-line chemotherapy for colorectal cancer. However, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. Variceal bleeding, as the most common complication of p...

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News  3,405 results

Role of Genomic Testing in mCRC
https://www.onclive.com/view/role-of-genomic-testing-in-mcrc

Nov 30th, 2021 - Tanios S. Bekaii-Saab, MD: The other thing that also has moved the needle quite a bit in our international practices is the availability of genomic testing. For those patients, especially those who present with later stages, the availability of ge...

Hochster Shares Best Practices on Molecular Markers and Sequencing in Gastric Cancer
https://www.onclive.com/view/hochster-shares-best-practices-on-molecular-markers-and-sequencing-in-gastric-cancer

Nov 29th, 2021 - For patients with gastric cancer, utilizing molecular markers and genomic profiling is becoming more crucial in guiding treatment decisions, according to Howard S. Hochster, MD. For patients with gastric cancer, immunotherapy has become part of...

Diet That Promotes Sulfur-Metabolizing Bacteria Tied to Colorectal Cancer Risk
https://www.medscape.com/viewarticle/963482

Nov 23rd, 2021 - NEW YORK (Reuters Health) - Following a diet that promotes sulfur-metabolizing bacteria - e.g., rich in French fries, red and processed meats, and low in fruits, vegetables and grains - is associated with increased risk of colorectal cancer (CRC),...

A Single Flexible Sigmoidoscopy Screening Tied to Long-Term Protection Against Colorectal Cancer
https://www.medscape.com/viewarticle/963395

Nov 22nd, 2021 - NEW YORK (Reuters Health) - In adults ages 55 to 64, a single flexible sigmoidoscopy (FS) screening is associated with a substantial reduction in colorectal cancer (CRC) incidence and mortality, with a protective effective lasting up to 18 years, ...

Survival the Same for Younger and Older Patients With Metastatic CRC
https://www.medscape.com/viewarticle/963361

Nov 19th, 2021 - Even though younger patients with metastatic colorectal cancer (CRC) tend to be fitter and receive more intensive treatment than older patients, overall survival (OS) and progression-free survival (PFS) are remarkably similar between the two group...

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Patient Education  33 results see all →