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Gastroesophageal Reflux Disease - StatPearls
Antunes, C. et. al.

Oct 26th, 2018 - Gastroesophageal reflux disease (GERD) is a condition that develops when there is a retrograde flow of stomach contents causing symptoms or complications. GERD can present as Non-erosive reflux disease (NERD) when typical symptoms of GERD occur in the absence of visible mucosal injury during endoscopy, or as erosive esophagitis (EE) when patients have histopathological changes in esophageal muc...

Refractory gastroesophageal reflux disease
Gastroenterology Report; Subramanian, C. et. al.

Aug 30th, 2014 - Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of stomach contents into the esophagus causes troublesome symptoms, esophageal injury, and/or complications. Use of proton pump inhibitors (PPI) remains the standard therapy for GERD and is effective in most patients. Those whose symptoms are refractory to PPIs should be evaluated further and other treatment opt...

Testing for refractory gastroesophageal reflux disease

Aug 21st, 2012 - Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Although proton pump inhibitors (PPIs) are proven to be effective in the treatment of GERD, inadequate symptom response to once daily, and according to some, twice‐daily dosage is accepted as refractory GERD. Non‐erosive reflux disease...

Refractory heartburn
Gastroenterology Kahrilas, P.

May 31st, 2003 - A 33-year-old woman presents to her primary care physician with a chief complaint of heartburn for the past 12 months. She describes this as a severe burning discomfort beneath the breastbone occurring throughout the day. The patient has no history of dysphagia, vomiting, weight loss, or gastrointestinal bleeding. She reports regurgitation once a month, unchanged in the recent past. Reasoning t...

METOZOLV ODT (metoclopramide hydrochloride) Prescribing Information

METOZOLV ODT is indicated for the relief of symptoms associated with acute and recurrent diabetic gastroparesis (gastric stasis) in adults. METOZOLV ODT is indicated for adults only. Therapy should not exceed 12 weeks in duration. The safety and effectiveness in pediatric patients have not been established.

LINX® Reflux Management System | J & J Medical Devices

The LINX® Reflux Management System is a laparoscopic, fundic-sparing anti-reflux procedure indicated for patients diagnosed with Gastroesophageal Reflux Disease (GERD).

Amneal Pharma issues recall for ranitidine products
MDedge Internal Medicine; Lucas Franki

Nov 13th, 2019 - Amneal Pharmaceuticals has announced a voluntary recall for both ranitidine tablets and ranitidine syrup because of potential N-nitrosodimethylamine (NDMA) levels above Food and Drug Administration–allowed cutoffs, according to an FDA MedWatch alert. NDMA, a probable human carcinogen, has been found in several different ranitidine products since an initial FDA announcement in September 2019.

Magnetic sphincter augmentation controls regurgitation
Heidi Splete

Sep 26th, 2019 - Adults with moderate to severe regurgitation showed significant improvement after magnetic sphincter augmentation, compared with increased proton pump inhibitor therapy, based on data from 152 patients. Proton pump inhibitors (PPIs) are often prescribed for patients with refractory gastroesophageal reflux disease (GERD), but these medications do not address the weakness in the lower esophageal.

GERD a Risk Factor for Temporomandibular Joint Disorders

Aug 23rd, 2019 - NEW YORK (Reuters Health) - Gastroesophageal reflux disease (GERD) is associated with a nearly three-fold increased risk of temporomandibular disorders (TMD), according to a new case-control study. "We found that symptomatic GERD is associated with painful chronic TMD, and somatization, anxiety and undermined sleep mediate this association moderately," Dr. Franklin R. Tay of The Dental College ...

Fast Five Quiz: Idiopathic Pulmonary Fibrosis Treatment

Jun 16th, 2019 - Idiopathic pulmonary fibrosis (IPF) and usual interstitial pneumonitis (UIP) are the most common forms of chronic, progressive fibrosing interstitial pneumonia of unknown origin. Although the cause of IPF is unknown, factors thought to increase an individual's risk of developing IPF include a history of smoking, gastroesophageal reflux disease, environmental exposures, and genetic predispositio...

GERD Reduction Overestimated After Gastric Bypass

Jun 4th, 2019 - Gastric bypass surgery relieved symptoms of gastroesophageal reflux disease (GERD) in only approximately half of patients with severe obesity, according to results from a nationwide cohort study with long follow-up. "This is a lower success rate than in previous studies, indicating that the treatment effect may have been overstated," write Dag Holmberg, a PhD student at Karolinska Institutet, K...

Pediatric gastroesophageal reflux
MDedge Family Medicine; Neil Skolnik, MD, Sophie Oh, MD

Jun 3rd, 2019 - Gastroesophageal reflux (GER) is common in infants and often presents a challenge to doctors who try to balance changing evidence with concerns about complications and parents’ concerns about their infant’s discomfort. In a 2018 guideline, the writing committee defined GER as reflux of stomach contents to the esophagus.

From sweet to belligerent in the blink of an eye
P. Brittany Vickery, PharmD, BCPS, BCPP, Kailey Hoots

Jun 1st, 2019 - CASE Combative and agitated Ms. P, age 87, presents to the emergency department (ED) with her caregiver, who says Ms.

Coffee, tea, and soda all up GERD risk
MDedge Internal Medicine; Kari Oakes

May 24th, 2019 - SAN DIEGO – Coffee, tea, and soda consumption are all associated with increased risk for gastroesophageal reflux disease (GERD), according to a new prospective cohort study presented at the annual Digestive Disease Week. In an interview following the oral presentation, Raaj S.

Treatment-resistant GERD reported by more than half of patients
MDedge Internal Medicine; Lora T. McGlade

May 22nd, 2019 - SAN DIEGO – Gastroesophageal reflux disease refractory to proton pump inhibitors may affect nearly half of those treated, according to the findings of a population-based sample of more than 70,000 Americans. As part of the National Institutes of Health GI Patient Reported Outcomes Measurement Information System (NIH GI-PROMIS) questionnaire, respondents could download a free app called “My GI H.

Study: Surgeon post-SG reflux rates vary widely
Richard Mark Kirkner

May 14th, 2019 - BALTIMORE – An analysis of sleeve gastrectomy (SG) operations reported to a statewide registry over a 5-year period has found that the proportion of patients with worsening gastroesophageal reflux disease (GERD) symptoms varied widely among surgeons despite similarities in surgeon training, experience, skills, technique, and complication rates, according to findings presented at the annual meet.

Adult-Onset Asymmetrical Lipomatosis
Xinyi Yang, BMed MD, MMed(ClinEpi), Megan Rogge, MD et. al.

May 8th, 2019 - To the Editor: An 85-year-old woman presented with extra growth of subcutaneous fat at the left anterior infradiaphragm that expanded circumferentially to the left back over the last 4 years. Two years prior to the current presentation, the left thigh became visibly thicker than the right.

Laparoscopic Surgery Effective for Chronic Reflux-Linked Cough

May 6th, 2019 - NEW YORK (Reuters Health) - Laparoscopic antireflux surgery (LARS) is an effective treatment for chronic cough associated with gastroesophageal reflux disease, with three-quarters of patients having complete resolution of symptoms, researchers report. "Patients with chronic cough are among the most desperate, lowest-quality-of-life folks you'll ever encounter in clinic," Dr. Adrian Park of Anne...

Treating CAP: Which Oral Drug Is Best After Discharge?

May 5th, 2019 - Community-Acquired Pneumonia What's the best de-escalation antibiotic therapy for community-acquired pneumonia (CAP) when no definitive pathogen is found? It's a common scenario, but with all of the bad news about fluoroquinolones lately, the right course isn't as straightforward as it used to be. As an infectious diseases specialist, I'll share my thoughts about choosing an effective alternati...

Anxiety can impact patient satisfaction after GERD surgery
Richard Mark Kirkner

Apr 16th, 2019 - BALTIMORE – Patients who take benzodiazepines for anxiety and have laparoscopic Nissen fundoplication for gastroesophageal reflux disease achieve similar outcomes as other patients, but also have much lower rates of postop satisfaction, according to a study from the Ohio State University presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons. DAJ/Thinkst.