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About 2,535 results

ALLMedicine™ Alcoholic Hepatitis Center

Research & Reviews  1,179 results

Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disea...
https://doi.org/10.1073/pnas.2020868118
Proceedings of the National Academy of Sciences of the United States of America; Wang Q, Kim SY et. al.

Jan 14th, 2021 - Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) is a pattern recognition receptor for single-stranded RNA, and its act...

MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation...
https://doi.org/10.1016/j.aohep.2021.100305
Annals of Hepatology; Li H, Zhang L et. al.

Jan 12th, 2021 - Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied. AH mice model and primarily cultured mice hepatic stellate ce...

Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease.
https://doi.org/10.1016/j.intimp.2020.107327
International Immunopharmacology; Yang C, He X et. al.

Jan 7th, 2021 - Alcoholic hepatitis (AH) has caused serious mortality to the world's population. Despite tremendous efforts to reduce disease burden, effective treatments for this disease are still lacking. Ginsenoside Rg1 (G-Rg1) has been reported to be hepatopr...

The diagnostic and prognostic significance of liver histology in alcoholic hepatitis.
https://doi.org/10.1111/apt.16157
Alimentary Pharmacology & Therapeutics REFERENCES; Forrest E, Petts G et. al.

Dec 16th, 2020 - Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. To assess the utility of liver biopsy in the assessment of clinically severe AH METHODS: The histological features of alcoholic...

INTEGRATED MULTI-OMICS REVEALS GLUCOSE USE REPROGRAMMING AND IDENTIFIES A NOVEL HEXOKIN...
https://doi.org/10.1053/j.gastro.2020.12.008
Gastroenterology Massey V, Parrish A et. al.

Dec 14th, 2020 - We recently demonstrated that alcoholic hepatitis (AH) is characterized by de-differentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH may lead to metabolic...

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Guidelines  7 results

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease
https://www.journal-of-hepatology.eu/article/S0168-8278(18)30214-9/fulltext
European Association for the Study of the Liver

Jun 30th, 2018 - The harmful use of alcohol has been estimated to cause approximately 3. 3?million deaths every year, corresponding to nearly 6% of all deaths globally.

ACG Clinical Guideline: Alcoholic Liver Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524956
The American Journal of Gastroenterology; Singal AK, Bataller R et. al.

Jan 17th, 2018 - Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of ...

Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute
https://www.cghjournal.org/article/S1542-3565(16)30798-4/fulltext?code=yjcgh-site

Apr 16th, 2017 - The purpose of this clinical practice update is to review diagnostic criteria for severe acute alcoholic hepatitis and to determine the current best practices for this life-threatening condition. The best practices in this review are based on clin...

Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287362
Gastroenterology Crabb DW, Bataller R et. al.

Feb 27th, 2016 - Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.|2016|Crabb DW,Bataller R,Chalasani NP,Kamath PS,Lucey M,|classification,standards,...

Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209530
World Journal of Gastroenterology; Testino G, Burra P et. al.

Oct 30th, 2014 - Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attributed to alcohol. Alcoholic liv...

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Clinicaltrials.gov  1,247 results

Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disea...
https://doi.org/10.1073/pnas.2020868118
Proceedings of the National Academy of Sciences of the United States of America; Wang Q, Kim SY et. al.

Jan 14th, 2021 - Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) is a pattern recognition receptor for single-stranded RNA, and its act...

MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation...
https://doi.org/10.1016/j.aohep.2021.100305
Annals of Hepatology; Li H, Zhang L et. al.

Jan 12th, 2021 - Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied. AH mice model and primarily cultured mice hepatic stellate ce...

Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease.
https://doi.org/10.1016/j.intimp.2020.107327
International Immunopharmacology; Yang C, He X et. al.

Jan 7th, 2021 - Alcoholic hepatitis (AH) has caused serious mortality to the world's population. Despite tremendous efforts to reduce disease burden, effective treatments for this disease are still lacking. Ginsenoside Rg1 (G-Rg1) has been reported to be hepatopr...

The diagnostic and prognostic significance of liver histology in alcoholic hepatitis.
https://doi.org/10.1111/apt.16157
Alimentary Pharmacology & Therapeutics REFERENCES; Forrest E, Petts G et. al.

Dec 16th, 2020 - Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. To assess the utility of liver biopsy in the assessment of clinically severe AH METHODS: The histological features of alcoholic...

INTEGRATED MULTI-OMICS REVEALS GLUCOSE USE REPROGRAMMING AND IDENTIFIES A NOVEL HEXOKIN...
https://doi.org/10.1053/j.gastro.2020.12.008
Gastroenterology Massey V, Parrish A et. al.

Dec 14th, 2020 - We recently demonstrated that alcoholic hepatitis (AH) is characterized by de-differentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH may lead to metabolic...

see more →

News  95 results

Serum keratin 18 promising as AAH biomarker
https://www.mdedge.com/gihepnews/article/216383/hepatology/serum-keratin-18-promising-aah-biomarker?channel=346
M. Alexander Otto, MDedge News

Jan 29th, 2020 - Serum keratin 18, an epithelial protein released from dying hepatocytes, identifies patients with severe acute alcoholic hepatitis (AAH) at high risk for death, according to an investigation of 173 subjects. Standard biomarker scores – Model for E.

DUR-928 shows promise for alcoholic hepatitis
https://www.mdedge.com/internalmedicine/article/211817/liver-disease/dur-928-shows-promise-alcoholic-hepatitis?channel=226
Will Pass

Nov 8th, 2019 - BOSTON – Treatment with novel agent DUR-928 may be able to reduce mortality rates among patients with severe alcoholic hepatitis, investigators predicted. In an open-label, phase IIa trial, 89% of patients with alcoholic hepatitis responded to tre.

Perceptions of liver transplantation for ALD are evolving
https://www.mdedge.com/gihepnews/article/193024/hepatology/perceptions-liver-transplantation-ald-are-evolving?channel=346
Caleb Rans, MDedge News

Jan 22nd, 2019 - In recent years, the proportion of patients undergoing liver transplantation for alcohol-associated liver disease (ALD) has doubled, suggesting a major shift in attitudes related to transplant indication, according to an analysis of registry data.

Correction: Liver enzymes
https://www.mdedge.com/ccjm/article/175927/correction-liver-enzymes

Oct 1st, 2018 - In the article by Agganis B, Lee D, Sepe T ( Liver enzymes: No trivial elevations, even if asymptomatic. Cleve Clin J Med 2018; 85(8):612–617, doi:10.

Treating Alcoholic Liver Diseases Requires a Full-Spectrum Approach
https://www.medscape.com/viewarticle/899082

Jul 15th, 2018 - Alcoholism: A Global Disorder Consumption of alcohol-containing (ethanol) beverages is a worldwide cause of preventable alcoholic liver disease[1] and can add to the progression of other liver diseases, such as hepatitis C virus infection.[2] Alco...

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Patient Education  7 results see all →