ALLMedicine™ Alcoholic Hepatitis Center

Jan 14th, 2021 - Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) is a pattern recognition receptor for single-stranded RNA, and its act...

Jan 12th, 2021 - Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied. AH mice model and primarily cultured mice hepatic stellate ce...

Jan 7th, 2021 - Alcoholic hepatitis (AH) has caused serious mortality to the world's population. Despite tremendous efforts to reduce disease burden, effective treatments for this disease are still lacking. Ginsenoside Rg1 (G-Rg1) has been reported to be hepatopr...

Dec 16th, 2020 - Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. To assess the utility of liver biopsy in the assessment of clinically severe AH METHODS: The histological features of alcoholic...

Dec 14th, 2020 - We recently demonstrated that alcoholic hepatitis (AH) is characterized by de-differentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH may lead to metabolic...

Jun 30th, 2018 - The harmful use of alcohol has been estimated to cause approximately 3. 3?million deaths every year, corresponding to nearly 6% of all deaths globally.

Jan 17th, 2018 - Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of ...

Apr 16th, 2017 - The purpose of this clinical practice update is to review diagnostic criteria for severe acute alcoholic hepatitis and to determine the current best practices for this life-threatening condition. The best practices in this review are based on clin...

Feb 27th, 2016 - Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.|2016|Crabb DW,Bataller R,Chalasani NP,Kamath PS,Lucey M,|classification,standards,...

Oct 30th, 2014 - Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attributed to alcohol. Alcoholic liv...

Jan 14th, 2021 - Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) is a pattern recognition receptor for single-stranded RNA, and its act...

Jan 12th, 2021 - Alcoholic hepatitis (AH) is characterized by high morbidity and mortality. MicroRNA-494-3p is possibly involved in the regulation of cancers, but its role in AH has been rarely studied. AH mice model and primarily cultured mice hepatic stellate ce...

Jan 7th, 2021 - Alcoholic hepatitis (AH) has caused serious mortality to the world's population. Despite tremendous efforts to reduce disease burden, effective treatments for this disease are still lacking. Ginsenoside Rg1 (G-Rg1) has been reported to be hepatopr...

Dec 16th, 2020 - Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. To assess the utility of liver biopsy in the assessment of clinically severe AH METHODS: The histological features of alcoholic...

Dec 14th, 2020 - We recently demonstrated that alcoholic hepatitis (AH) is characterized by de-differentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH may lead to metabolic...

Jan 29th, 2020 - Serum keratin 18, an epithelial protein released from dying hepatocytes, identifies patients with severe acute alcoholic hepatitis (AAH) at high risk for death, according to an investigation of 173 subjects. Standard biomarker scores – Model for E.

Nov 8th, 2019 - BOSTON – Treatment with novel agent DUR-928 may be able to reduce mortality rates among patients with severe alcoholic hepatitis, investigators predicted. In an open-label, phase IIa trial, 89% of patients with alcoholic hepatitis responded to tre.

Jan 22nd, 2019 - In recent years, the proportion of patients undergoing liver transplantation for alcohol-associated liver disease (ALD) has doubled, suggesting a major shift in attitudes related to transplant indication, according to an analysis of registry data.

Oct 1st, 2018 - In the article by Agganis B, Lee D, Sepe T ( Liver enzymes: No trivial elevations, even if asymptomatic. Cleve Clin J Med 2018; 85(8):612–617, doi:10.

Jul 15th, 2018 - Alcoholism: A Global Disorder Consumption of alcohol-containing (ethanol) beverages is a worldwide cause of preventable alcoholic liver disease[1] and can add to the progression of other liver diseases, such as hepatitis C virus infection.[2] Alco...