ALLMedicine™ Alcoholic Hepatitis Center
Research & Reviews 502 results
https://doi.org/10.1038/s41467-021-24843-w 10.1016/S0168-8278(01)00289-6 10.1016/S2468-1253(19)30326-7 10.1016/j.jhep.2018.10.023 10.1038/nbt.1685 10.1016/j.jcmgh.2018.09.005 10.1038/nsmb.2470 10.1038/nrg2957 10.1038/nrm3949 10.1073/pnas.1016071107 10.1038/nrg3682 10.1016/j.molcel.2014.08.024 10.1136/gutjnl-2013-306603 10.1038/nri3399 10.1053/j.gastro.2009.01.056 10.1053/j.gastro.2019.03.013 10.1101/gad.183434.111 10.3390/genes6020299 10.1371/journal.pone.0151063 10.1002/hep.30472 10.1152/ajpgi.00031.2015 10.1046/j.1440-1746.2000.02174.x 10.1016/j.molcel.2019.07.028 10.1038/s41586-019-1373-2 10.1371/journal.pone.0095846 10.1016/j.immuni.2018.09.018 10.1038/s41588-018-0298-2 10.15252/embj.2019103949 10.1080/21541264.2017.1372044 10.1016/j.cell.2013.06.044 10.1016/j.bmcl.2012.02.041 10.1038/nature11247 10.1016/j.cell.2014.11.021 10.1038/nature12644 10.1016/j.cell.2016.09.037 10.1038/cr.2016.1 10.1073/pnas.1424028112 10.1101/gad.1998010 10.1038/s41467-017-02055-5 10.1038/nprot.2013.032 10.1189/jlb.0809532 10.1038/s41598-017-09045-z 10.1002/hep.22847 10.1002/cld.168 10.1136/gutjnl-2011-301146 10.1016/j.immuni.2019.08.017 10.1002/hep.27921 10.1038/nature17040 10.1038/s41586-020-2424-4 10.1038/s41467-018-06318-7 10.1016/j.jcmgh.2020.07.012 10.1038/s41588-019-0494-8 10.1126/science.aao2793 10.1126/science.aal2066 10.1093/annonc/mdx157 10.1128/MCB.01365-08 10.1021/acs.jmedchem.0c00035 10.1016/j.chembiol.2014.05.009 10.1038/onc.2013.179 10.1038/s41598-018-35653-4 10.1016/j.jhep.2018.10.026
Nature Communications; Liu M, Cao S et. al.
Jul 29th, 2021 - Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we e...
https://doi.org/10.1001/jama.2021.7683
JAMA Singal AK, Mathurin P
Jul 14th, 2021 - Alcohol-associated liver disease results in cirrhosis in approximately 10% to 20% of patients. In 2017, more than 2 million people had alcohol-associated cirrhosis in the US. Alcohol-associated liver disease is the primary cause of liver-related m...
https://doi.org/10.1007/s10620-021-07140-w 10.1016/j.jhep.2018.12.008 10.1056/NEJMra0805786 10.1053/j.gastro.2016.02.042 10.1016/j.jhep.2011.02.021 10.1111/apt.12427 10.1097/MEG.0000000000000926 10.1056/NEJMoa1412278 10.1016/0016-5085(78)90401-8 10.1136/gut.2004.050781 10.1111/j.1572-0241.2008.02104.x 10.1002/hep.510230122 10.1136/gutjnl-2014-308874 10.1111/apt.15335 10.1007/s10620-013-3020-3 10.1155/2015/814827 10.1097/MCG.0b013e3181fdef1d 10.1002/hep.27779 10.1053/j.gastro.2009.04.062 10.1016/j.jhep.2017.06.013 10.1016/j.jhep.2013.09.011 10.1002/lt.24702 10.1016/j.cgh.2018.04.045 10.1111/apt.15932 10.1038/cmi.2014.2 10.1016/j.jhep.2005.10.013 10.1016/j.cgh.2016.09.157 10.1002/lt.21129
Digestive Diseases and Sciences; Vaz K, Little R et. al.
Jul 8th, 2021 - Alcoholic hepatitis is a common condition with high mortality. This study aimed to firstly describe the presentation, treatment, and short- and long-term outcomes of an Australian cohort of patients admitted to hospital with alcoholic hepatitis an...
https://doi.org/10.1016/j.cld.2021.04.001
Clinics in Liver Disease; Morgan MY, Sharma M et. al.
Jul 8th, 2021 - Constitutional, environmental, and genetic risk factors influence the development of alcohol-related cirrhosis. The amount of alcohol consumed and whether excessive drinking continues after the identification of pre-cirrhotic liver damage are key ...
https://doi.org/10.1016/j.cld.2021.03.004
Clinics in Liver Disease; Mitra A, Myers L et. al.
Jul 8th, 2021 - Acute alcoholic hepatitis is a clinical entity with significant consequences. Those with severe disease can have high short-term mortality, and considerations for liver transplant candidacy may be raised. Estimating prognosis and mortality is of t...
Guidelines 3 results
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524956
The American Journal of Gastroenterology; Singal AK, Bataller R et. al.
Jan 18th, 2018 - Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of ...
https://www.cghjournal.org/article/S1542-3565(16)30798-4/fulltext?code=yjcgh-site
Apr 17th, 2017 - The purpose of this clinical practice update is to review diagnostic criteria for severe acute alcoholic hepatitis and to determine the current best practices for this life-threatening condition. The best practices in this review are based on clin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287362
Gastroenterology Crabb DW, Bataller R et. al.
Feb 28th, 2016 - Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.|2016|Crabb DW,Bataller R,Chalasani NP,Kamath PS,Lucey M,|classification,standards,...
Clinicaltrials.gov 30 results
https://clinicaltrials.gov/ct2/show/NCT02473341
Feb 13th, 2020 - Diagnosis: The diagnosis of Alcoholic hepatitis is made by the following criteria (12) I. Chronic active alcohol abuse - >80 grams in males and > 60 grams in females for > 5 years for developing Alcoholic Cirrhosis (13) Alcohol use will be evaluat...
https://clinicaltrials.gov/ct2/show/NCT02458079
Aug 15th, 2019 - Treatment for severe alcoholic hepatitis patients not eligible for steroid therapy is a dilemma. Pentoxyfilline has been shown to have no improvement in outcomes as per current studies and liver transplantation is with great risk of recidivism in ...
https://clinicaltrials.gov/ct2/show/NCT03294941
Aug 12th, 2019 - The HepQuant study is to run parallel to the Gilead clinical trials,GS-US-416-2124 trial of Alcoholic Hepatitis, GS-US-384-1943 trial of non-alcoholic steatohepatitis (NASH) fibrosis Stage 3 (STELLAR-3), and, GS-US-384-1944 trial of NASH and compe...
https://clinicaltrials.gov/ct2/show/NCT03267069
Mar 13th, 2019 - This is a longitudinal observational study. Subjects with a diagnosis of alcoholic liver disease (acute alcoholic hepatitis or alcoholic cirrhosis) who present to Weill Cornell Medical Center or Columbia University Medical Center New York Presbyte...
https://clinicaltrials.gov/ct2/show/NCT03452540
Nov 1st, 2018 - The purpose of this randomised, double-blind, placebo-controlled, phase II study is to assess the efficacy and safety of orally administered DS102 in patients with acute decompensated alcoholic hepatitis
News 64 results
https://www.mdedge.com/internalmedicine/article/218018/addiction-medicine/rising-number-young-people-dying-after-heavy?channel=39313
Marcia Frellick
Feb 27th, 2020 - MAUI, HAWAII – Alcohol use and deaths related to alcohol-use disorders are increasing, and young adults might be the group to watch, said Norah Terrault, MD, MPH, professor at the Keck School of Medicine of USC in Los Angeles. “A lot of young peop.
https://www.medscape.com/viewarticle/925377
Feb 18th, 2020 - MAUI, Hawaii — Alcohol use and deaths related to alcohol-use disorders are increasing, and young adults might be the group to watch, said Norah Terrault, MD, MPH, professor at the Keck School of Medicine of USC in Los Angeles. "A lot of young peop...
https://www.mdedge.com/gihepnews/article/216383/hepatology/serum-keratin-18-promising-aah-biomarker?channel=346
M. Alexander Otto, MDedge News
Jan 29th, 2020 - Serum keratin 18, an epithelial protein released from dying hepatocytes, identifies patients with severe acute alcoholic hepatitis (AAH) at high risk for death, according to an investigation of 173 subjects. Standard biomarker scores – Model for E.
https://www.medscape.com/viewarticle/922790_2
Dec 23rd, 2019 - 4. Adopt a Mediterranean diet. The Mediterranean diet is rich in plant-based foods, such as whole grains, seeds, nuts, legumes, fruits, and vegetables, and calls for moderate consumption of lean proteins, such as seafood and poultry, and avoidance...
https://www.staging.medscape.com/viewarticle/922790_2
Dec 23rd, 2019 - 4. Adopt a Mediterranean diet. The Mediterranean diet is rich in plant-based foods, such as whole grains, seeds, nuts, legumes, fruits, and vegetables, and calls for moderate consumption of lean proteins, such as seafood and poultry, and avoidance...
