ALLMedicine™ Fibrolamellar Carcinoma Center

Jul 17th, 2021 - Fibrolamellar carcinoma (FLC) is a rare malignant entity arising from the liver and primarily affecting patients in late adolescence and young adulthood. FLC tumors are characterized by their unique histologic features and an only recently discove...

Jun 15th, 2021 - To repurpose therapeutics for fibrolamellar carcinoma (FLC) we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically, and inhibitors of oncogenes overexpressed in FLC showed little efficacy ...

Mar 10th, 2021 - There are no standard systemic therapies for the treatment of fibrolamellar carcinoma (FLC), as surgery remains the only definitive option. We share our experiences using systemic "triple therapy" (TT) with 5-fluorouracil, interferon, and nivoluma...

Aug 9th, 2020 - Fibrolamellar carcinoma (FLC) is a rare and poorly understood malignancy, which seems to be more prevalent in young patients compared with conventional hepatocellular carcinoma (HCC). Performing prospective clinical trials recruiting patients diag...

Jul 14th, 2020 - Fibrolamellar carcinoma (FLC) is a rare primary liver cancer of young adults. A functional chimeric transcript resulting from the in-frame fusion of the DNAJ homolog, subfamily B, member 1 (DNAJB1), and the catalytic subunit of protein kinase A (P...

Sep 5th, 2018 - Primary Objective: • To determine the 6-month progression free survival (PFS6) rate when patients with advanced fibrolamellar carcinoma (FLC) are treated with daily oral ENMD 2076 Secondary Objectives: To evaluate the overall response rate using R...

Mar 12th, 2014 - Fibrolamellar hepatocellular carcinoma is variant rare of hepatocellular carcinoma witch distinct clinical, histological and prognostic features from conventional hepatocellular carcinoma. This entity typically occurs in young adults with no under...

Apr 9th, 2013 - OBJECTIVES: To characterize, at a molecular level, archived samples of tissue from young patients with fibrolamellar carcinoma and hepatocellular carcinoma in non-cirrhotic livers matched for age and sex. To perform genomic analysis on these tissu...

Apr 15th, 2019 - Up-regulation of microRNA-375 may be a future therapeutic strategy for patients with fibrolamellar carcinoma (FLC), according to investigators. Analysis of primary FLC tumors showed that microRNA-375 was the most abnormal microRNA, down-regulated.

Jul 10th, 2014 - ENMD-2076, an oral Aurora A/angiogenic kinase inhibitor has received an orphan drug designation from the Food and Drug Administration to treat hepatocellular carcinoma, according to a statement issued by the manufacturer on July 7. With that statu.

May 17th, 2004 - Summary 38 year old female with worst headache of life. (Enlarge Image) (Enlarge Image) (Enlarge Image) (Enlarge Image) (Enlarge Image) A tumor of the liver associated with prior exposure to Thorotrast: Hemangioma Angiosarcoma FNH Fibrolamellar ca...