ALLMedicine™ Yellow Fever Center

Jul 30th, 2021 - A single dose of the replication-competent, live-attenuated yellow fever virus (YFV) 17D vaccine provides lifelong immunity against human YFV infection. The magnitude, kinetics, and specificity of B cell responses to YFV 17D are relatively less un...

Jul 30th, 2021 - Zika virus (ZIKV), alongside Dengue virus (DENV), Chikungunya virus (CHIKV), and Yellow Fever Virus (YFV) are prevalent arboviruses in the Americas. Each of these infections is associated with the development of associated disease immunopathology....

Jul 29th, 2021 - Aedes mosquitoes are important invasive species contributing to the spread of chikungunya, dengue fever, yellow fever, zika virus, and other dangerous vector-borne diseases. Aedes albopictus is native to southeast Asia, with rapid expansion due to...

Jul 23rd, 2021 - The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate change, we expect an increase in both global mean temperatures and extreme c...

Jul 21st, 2021 - Mosquito-borne flaviviruses are prime pathogens and have been a major hazard to humans and animals. They comprise several arthropod-borne viruses, including dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. Culex ...

Oct 18th, 2019 - The goal of this study is to characterize immune memory in humans who have previously received yellow fever vaccine. The project is designed to study the magnitude and persistence of both humoral, and cell-mediated immune memory generated post-vac...

Jun 20th, 2019 - The vaccine tested in this study is TDV also known as TAK-003 (DENVax). TDV with concomitant administration of yellow fever (YF-17D) vaccine will be tested to assess immunogenicity and safety in healthy participants in non-endemic area(s) for both...

Feb 11th, 2019 - In general, T cell responses to viral infections occur in three distinct stages: expansion, contraction and memory. During expansion, antigen-specific CD8+ T cells proliferate to increase in numbers as well as acquire the ability to kill virus inf...

Oct 31st, 2018 - Yellow fever (YF) is a potentially fatal disease causing some 29,000 - 60,000 deaths in Africa alone in 2013. Vaccination with the YF vaccine is the most effective way of preventing YF and a single full dose of vaccine provides life-long protectio...

Oct 1st, 2018 - The objective of this study is to study immune memory generated against the yellow fever vaccine (YFV) in participants who recently received the YFV vaccine. Volunteers who are planning to travel to yellow fever endemic areas will be recruited int...

Jun 14th, 2021 - A modestly titled new study released in the New England Journal of Medicine belies the extraordinary 77% protective efficacy reported for preventing dengue infections with Wolbachia-infected Aedes aegypti mosquitoes. A cluster-randomized clinical ...

Apr 27th, 2021 - LONDON (Reuters) - Millions of children whose immunisations have been disrupted by the COVID-19 pandemic, especially in Africa, are now at risk from life-threatening diseases such as measles, polio, yellow fever and diphtheria, U.N. health agencie...

Jun 15th, 2020 - (Reuters) - Five years ago, in an office complex with a giant sculpture of a mosquito just northwest of Phnom Penh, Jessica Manning struck on a novel idea. Rather than spend more years in what felt like a futile search for a malaria vaccine, she w...

May 19th, 2020 - BRASILIA/MEXICO CITY (Reuters) - The World Health Organization’s director for the Americas warned on Tuesday of a coronavirus surge across the region and voiced hope for continuing U.S. help to tackle the outbreak, despite President Donald Trump’s...

Apr 28th, 2020 - GENEVA (Reuters) - The coronavirus pandemic is “far from over” and is still disrupting normal health services, especially life-saving immunisation for children in the poorest countries, the head of the World Health Organization (WHO) said on Monda...