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About 4,118 results

ALLMedicine™ Familial Adenomatous Polyposis Center

Research & Reviews  2,015 results

Early Development of Colonic Adenocarcinoma With Minimal Polyposis in a Young Child Wit...
https://doi.org/10.1097/MPH.0000000000002209
Journal of Pediatric Hematology/oncology; Liu APY, Chung PHY et. al.

May 18th, 2021 - Germline adenomatous polyposis coli (APC) gene mutation is a cancer-predisposing condition commonly presenting as familial adenomatous polyposis. We describe a patient first diagnosed at the age of 3 years with metastatic hepatoblastoma. With a po...

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133103
Clinical and Translational Gastroenterology; Jennelle LT, Dampier CH et. al.

May 17th, 2021 - Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer (CRC) syndrome characterized by accelerated adenoma development due to inherited (or de novo) mutations in the APC regulator of WNT signaling pathway (APC) gene. The mechanism ...

Cutaneous desmoid-type fibromatosis: a rare case with molecular profiling.
https://doi.org/10.1111/cup.14058
Journal of Cutaneous Pathology; Aghighi M, Cloutier JM et. al.

May 12th, 2021 - Fibromatoses encompass a broad group of histopathologically similar fibroblastic/myofibroblastic proliferations with divergent clinical manifestations and behavior. Deep (desmoid-type) fibromatoses are typically large, rapidly growing, and locally...

Incidence and Management of Rectal Cuff and Anal Transitional Zone Neoplasia in Patient...
https://doi.org/10.1097/DCR.0000000000001967
Diseases of the Colon and Rectum; Lee CHA, Kalady MF et. al.

May 7th, 2021 - Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly do...

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Guidelines  4 results

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Guide to endoscopy of the ileo-anal pouch following restorative proctocolectomy with il...
https://doi.org/10.1002/ibd.20874
Inflammatory Bowel Diseases; McLaughlin SD, Clark SK et. al.

Jan 30th, 2009 - Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant p...

Guidelines for the clinical management of familial adenomatous polyposis (FAP).
https://doi.org/10.1136/gut.2007.136127
Gut Vasen HF, Möslein G et. al.

Jan 15th, 2008 - Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to thousands of adenomas in the colorectum...

Stomach (Gastric) Cancer Prevention (PDQ®)–Health Professional Version
https://www.cancer.gov/types/stomach/hp/stomach-prevention-pdq?cid=eb_govdel
National Cancer Institute

People at elevated risk for gastric cancer include elderly patients with atrophic gastritis or pernicious anemia, patients with sporadic gastric adenomas,[1] familial adenomatous polyposis,[2] or hereditary nonpolyposis colon cancer,[3] and immigr...

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Clinicaltrials.gov  2,053 results

Early Development of Colonic Adenocarcinoma With Minimal Polyposis in a Young Child Wit...
https://doi.org/10.1097/MPH.0000000000002209
Journal of Pediatric Hematology/oncology; Liu APY, Chung PHY et. al.

May 18th, 2021 - Germline adenomatous polyposis coli (APC) gene mutation is a cancer-predisposing condition commonly presenting as familial adenomatous polyposis. We describe a patient first diagnosed at the age of 3 years with metastatic hepatoblastoma. With a po...

Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133103
Clinical and Translational Gastroenterology; Jennelle LT, Dampier CH et. al.

May 17th, 2021 - Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer (CRC) syndrome characterized by accelerated adenoma development due to inherited (or de novo) mutations in the APC regulator of WNT signaling pathway (APC) gene. The mechanism ...

Cutaneous desmoid-type fibromatosis: a rare case with molecular profiling.
https://doi.org/10.1111/cup.14058
Journal of Cutaneous Pathology; Aghighi M, Cloutier JM et. al.

May 12th, 2021 - Fibromatoses encompass a broad group of histopathologically similar fibroblastic/myofibroblastic proliferations with divergent clinical manifestations and behavior. Deep (desmoid-type) fibromatoses are typically large, rapidly growing, and locally...

Incidence and Management of Rectal Cuff and Anal Transitional Zone Neoplasia in Patient...
https://doi.org/10.1097/DCR.0000000000001967
Diseases of the Colon and Rectum; Lee CHA, Kalady MF et. al.

May 7th, 2021 - Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly do...

see more →

News  35 results

Chemoprevention With Low-Dose Aspirin Promising in Familial Adenomatous Polyposis
https://www.medscape.com/viewarticle/948958

Apr 8th, 2021 - NEW YORK (Reuters Health) - Low-dose aspirin can suppress the recurrence of colorectal polyps larger than 5.0 mm in patients with familial adenomatous polyposis (FAP), according to results of the J-FAPP Study IV. "Because colorectal polyps larger ...

Secondary bile acid deficiency may be culprit in UC inflammation
https://www.mdedge.com/gihepnews/article/218027/gastroenterology/secondary-bile-acid-deficiency-may-be-culprit-uc?channel=345
Richard Mark Kirkner, MDedge News

Feb 27th, 2020 - Researchers have found three potential gut mechanisms linked to secondary bile acid (SBA) deficiencies implicated in intestinal inflammation in ulcerative colitis (UC), and reported that supplementation may aid in restoring bile acid levels and po.

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Sorafenib Improves Survival for Patients With Rare Sarcomas
https://www.mdedge.com/fedprac/avaho/article/165563/oncology/sorafenib-improves-survival-patients-rare-sarcomas
Jan Dyer

May 10th, 2018 - Promising results from a phase 3 trial could represent a paradigm shift in treatment of patients with desmoid tumors, say National Cancer Institute (NCI) researchers. Sorafenib tosylate extended progression-free survival (PFS) compared with that o.

Bacteria Identified as Oncogenic Drivers in Hereditary Cancer
https://www.medscape.com/viewarticle/892280

Feb 4th, 2018 - Two common species of bacteria and the biofilms they create have been identified as key oncogenic drivers in the process leading to colorectal cancer (CRC) in patients with familial adenomatous polyposis (FAP), and potentially sporadic forms of CR...

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Patient Education  11 results see all →