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About 4,004 results

ALLMedicine™ Familial Adenomatous Polyposis Center

Research & Reviews  1,959 results

A review of inherited cancer susceptibility syndromes.
https://doi.org/10.1097/01.JAA.0000721648.46099.2c
JAAPA : Official Journal of the American Academy of Physician Assistants; Brown GR, Simon M et. al.

Nov 25th, 2020 - Inherited cancer syndromes are caused by genetic mutations that place patients at an increased risk for developing cancer. Although most cancers are not caused by genetic inheritance, clinicians must understand these syndromes and be able to recog...

Gardner syndrome with giant abdominal desmoid tumor during pregnancy: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664105
BMC Surgery; Jin L, Tan Y et. al.

Nov 13th, 2020 - Gardner syndrome is a subtype of familial adenomatous polyposis (FAP), characterized by a combination of adenomatous intestinal polyps and extracolonic lesions such as multiple osteomas, dental abnormalities, and soft tissue tumors. Although 12% o...

The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecul...
https://doi.org/10.1007/s00439-020-02235-2
Human Genetics; Mima K, Kosumi K et. al.

Nov 12th, 2020 - Metagenomic studies using next-generation sequencing technologies have revealed rich human intestinal microbiome, which likely influence host immunity and health conditions including cancer. Evidence indicates a biological link between altered mic...

Retinal pigment epithelial lesions associated with a sporadic case of familial adenomat...
https://doi.org/10.1097/ICB.0000000000001072
Retinal Cases & Brief Reports; Alsberge JB, Peng MY et. al.

Nov 5th, 2020 - To report a sporadic case of a familial adenomatous polyposis (FAP) discovered in a patient with bilateral retinal pigment epithelial lesions. Case report. A 30-year-old Asian woman presented for evaluation of bilateral pigmented lesions at the le...

Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model.
https://doi.org/10.1016/j.clcc.2020.08.006
Clinical Colorectal Cancer; Parihar M, Dodds SG et. al.

Nov 2nd, 2020 - We previously showed that lifelong rapamycin treatment of short-lived ApcMin/+ mice, a model for familial adenomatous polyposis, resulted in a normal lifespan. ApcMin/+ mice develop colon polyps with a low frequency but can be converted to a colon...

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Guidelines  4 results

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in f...
https://doi.org/10.1016/j.gie.2020.01.028
Gastrointestinal Endoscopy; Yang J, Gurudu SR et. al.

Mar 14th, 2020 - Familial adenomatous polyposis (FAP) syndrome is a complex entity, which includes FAP, attenuated FAP, and MUTYH-associated polyposis. These patients are at significant risk for colorectal cancer and carry additional risks for extracolonic maligna...

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Guide to endoscopy of the ileo-anal pouch following restorative proctocolectomy with il...
https://doi.org/10.1002/ibd.20874
Inflammatory Bowel Diseases; McLaughlin SD, Clark SK et. al.

Jan 30th, 2009 - Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant p...

Guidelines for the clinical management of familial adenomatous polyposis (FAP).
https://doi.org/10.1136/gut.2007.136127
Gut Vasen HF, Möslein G et. al.

Jan 15th, 2008 - Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to thousands of adenomas in the colorectum...

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Clinicaltrials.gov  1,997 results

A review of inherited cancer susceptibility syndromes.
https://doi.org/10.1097/01.JAA.0000721648.46099.2c
JAAPA : Official Journal of the American Academy of Physician Assistants; Brown GR, Simon M et. al.

Nov 25th, 2020 - Inherited cancer syndromes are caused by genetic mutations that place patients at an increased risk for developing cancer. Although most cancers are not caused by genetic inheritance, clinicians must understand these syndromes and be able to recog...

Gardner syndrome with giant abdominal desmoid tumor during pregnancy: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664105
BMC Surgery; Jin L, Tan Y et. al.

Nov 13th, 2020 - Gardner syndrome is a subtype of familial adenomatous polyposis (FAP), characterized by a combination of adenomatous intestinal polyps and extracolonic lesions such as multiple osteomas, dental abnormalities, and soft tissue tumors. Although 12% o...

The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecul...
https://doi.org/10.1007/s00439-020-02235-2
Human Genetics; Mima K, Kosumi K et. al.

Nov 12th, 2020 - Metagenomic studies using next-generation sequencing technologies have revealed rich human intestinal microbiome, which likely influence host immunity and health conditions including cancer. Evidence indicates a biological link between altered mic...

Retinal pigment epithelial lesions associated with a sporadic case of familial adenomat...
https://doi.org/10.1097/ICB.0000000000001072
Retinal Cases & Brief Reports; Alsberge JB, Peng MY et. al.

Nov 5th, 2020 - To report a sporadic case of a familial adenomatous polyposis (FAP) discovered in a patient with bilateral retinal pigment epithelial lesions. Case report. A 30-year-old Asian woman presented for evaluation of bilateral pigmented lesions at the le...

Rapamycin Extends Life Span in ApcMin/+ Colon Cancer FAP Model.
https://doi.org/10.1016/j.clcc.2020.08.006
Clinical Colorectal Cancer; Parihar M, Dodds SG et. al.

Nov 2nd, 2020 - We previously showed that lifelong rapamycin treatment of short-lived ApcMin/+ mice, a model for familial adenomatous polyposis, resulted in a normal lifespan. ApcMin/+ mice develop colon polyps with a low frequency but can be converted to a colon...

see more →

News  31 results

Secondary bile acid deficiency may be culprit in UC inflammation
https://www.mdedge.com/gihepnews/article/218027/gastroenterology/secondary-bile-acid-deficiency-may-be-culprit-uc?channel=345
Richard Mark Kirkner, MDedge News

Feb 27th, 2020 - Researchers have found three potential gut mechanisms linked to secondary bile acid (SBA) deficiencies implicated in intestinal inflammation in ulcerative colitis (UC), and reported that supplementation may aid in restoring bile acid levels and po.

Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
https://academic.oup.com/annonc/advance-article-pdf/doi/10.1093/annonc/mdz233/29094053/mdz233.pdf

Aug 4th, 2019 - Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial aden...

Sorafenib Improves Survival for Patients With Rare Sarcomas
https://www.mdedge.com/fedprac/avaho/article/165563/oncology/sorafenib-improves-survival-patients-rare-sarcomas
Jan Dyer

May 10th, 2018 - Promising results from a phase 3 trial could represent a paradigm shift in treatment of patients with desmoid tumors, say National Cancer Institute (NCI) researchers. Sorafenib tosylate extended progression-free survival (PFS) compared with that o.

Bacteria Identified as Oncogenic Drivers in Hereditary Cancer
https://www.medscape.com/viewarticle/892280

Feb 4th, 2018 - Two common species of bacteria and the biofilms they create have been identified as key oncogenic drivers in the process leading to colorectal cancer (CRC) in patients with familial adenomatous polyposis (FAP), and potentially sporadic forms of CR...

Sulindac-erlotinib as chemoprevention for FAP
https://www.mdedge.com/gihepnews/article/143438/gi-oncology/sulindac-erlotinib-chemoprevention-fap
N. Jewel Samadder, MD, MSc, FRCP

Jul 27th, 2017 - Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder caused by germline mutations in the APC (adenomatous polyposis coli) gene. The disease is characterized by the formation of hundreds to thousands of adenomatous polyp.

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Patient Education  13 results see all →